Prevalence of osteoporosis with the World Health Organization diagnostic criteria in the Eastern Mediterranean Region: a systematic review and meta-analysis

Zamani, Mohammad; Zamani, Vahid; Heidari, Behzad; Parsian, Hadi; Esmaeilnejad-Ganji, Seyed Mokhtar

doi:10.1007/s11657-018-0540-7

Cited by 47 publications

(48 citation statements)

References 29 publications

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“…However, such heterogeneity is usually seen in the epidemiological studies and is not unexpected. (18,43)…”

Section: Discussionmentioning

confidence: 99%

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Incidence of Hip Fracture in the Eastern Mediterranean Region- A Systematic Review and Meta-Analysis

Zamani¹,

Esmaeilnejad-Ganji²,

Esmaeilnejad-Ganji³

2019

jemds

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BACKGROUND Hip fracture is a major health concern with high rates of mortality and disability. The purpose of this study was to conduct a systematic review and meta-analysis on the incidence of hip fracture in the Eastern Mediterranean Region (EMR). METHODS We searched the databases of PubMed, Scopus, Web of Science and Index Medicus for the EMR for observational studies reporting the incidence of fracture in the EMR countries, which were published from inception to September 2018 with no language restriction. Study selection and data extraction were conducted independently by two reviewers. RESULTS After applying inclusion and exclusion criteria, 10 articles were finally included in this study. The overall pooled crude incidence rate of hip fracture in the EMR was estimated to be 107.4 per 100,000 population/year (95% confidence interval [CI]: 83-131.8). Analysis also showed that the overall pooled age-standardized rate was 174.4 per 100,000 population/year (95% CI: 103.9-244.9). Lebanon had the highest crude incidence rate (140.1 per 100,000 population/year), and Kuwait had the lowest rate (21.9 per 100,000 population/year). Age-standardized rate for males was 121.3 per 100,000/year (95% CI: 80.8-161.7) and for females was 227.4 per 100,000/year (95% CI: 129-325.9). The overall crude incidence for traumatic fracture was estimated to be 79.2 per 100,000/year (95% CI: 21.8-136.6). CONCLUSIONS A considerable incidence rate was seen for hip fractures. There were also significant variations in the incidence of different countries of the EMR. Implementing preventive measures against fractures is needed in the region.

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“…However, such heterogeneity is usually seen in the epidemiological studies and is not unexpected. (18,43)…”

Section: Discussionmentioning

confidence: 99%

“…(16) Another survey from Iran reported a death rate of 11.2% during 2007-2008. (17) Our recent metaanalysis showed that the prevalence of osteoporosis has increased over the last years in the EMR (18) therefore, osteoporotic fractures will probably become more prevalent and become an even greater concern for this region.…”

mentioning

confidence: 99%

Incidence of Hip Fracture in the Eastern Mediterranean Region- A Systematic Review and Meta-Analysis

Zamani¹,

Esmaeilnejad-Ganji²,

Esmaeilnejad-Ganji³

2019

jemds

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“…Osteoporosis (OP) is a common bone disease characterized by decreased bone density, increased bone fragility, and increased risk of fracture [1]. According to the World Health Organization report, with the global population aging, approximately 72% of women and 62% of men over 50 years old are estimated to suffer from OP or osteopenia by 2022 [2]. OP has a high incidence of fractures and mortality rates and has become a global epidemic [3].…”

Section: Introductionmentioning

confidence: 99%

“…RAW264.7 cells are a well-established preosteoclast cell line. After treatment with specific growth factors, such as RANKL, RAW264.7 cells can be differentiated into osteoclasts [2]. Therefore, RANKL-induced RAW264.7 cells may be used for the study of osteoclasto genesis in vitro.…”

Section: Introductionmentioning

confidence: 99%

Effects of Rambutan Peel (Nepheliumlappaceum) PhenolicExtract on RANKL-Induced Differentiation of RAW264.7 Cells into Osteoclasts and Retinoic Acid-Induced Osteoporosis in Rats

Zhuang

Sun²,

Liu³

et al. 2020

Nutrients

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Previous studies have shown that rambutan peel phenolic (RPP) extract has excellent biological activities due to its abundant phenolic content and profile. In this study, the potential anti-osteoporosis (OP) effects of RPP were evaluated by suppressing receptor activator nuclear factor-kappa B ligand (RANKL)-induced differentiation of RAW264.7 cells into osteoclasts and amelioratingretinoic acid-induced OP in rats. Our results showed that RPP efficiently decreased the formation of tartrate-resistant acid phosphatase (TRAP)-positive cells and reduced total TRAP activity in RAW264.7 cells under RANKL stimulation. RPP treatment significantlyameliorated retinoid acid-induced calcium loss in rats (p < 0.05). The serum phosphorus level of osteoporotic rats was increased by RPP treatment, and the serum levels of total alkaline phosphatase and osteocalcin in osteoporotic rats were further reduced. RPP treatment improved the qualities of the femur and tibia, such asbone mineral density, bone length, bone maximum load, cortical bone area ratio, and trabecularelative bone density in osteoporotic rats to some extent. Furthermore, histological analysis showed that RPP effectively improved the bone microstructure of osteoporotic rats by regulating the cortical bone thickness and trabecular bone separation. These results indicate that RPP could have potential applications as a newnutraceutical and functional food in the prevention of OP.

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“…Considering the great inuence and serious consequences of osteoporosis, this disease is classied by the World Health Organization (WHO) as a major public health concern. [4][5][6] To restore proper bone structure and treat osteoporosis, it is important to re-establish the balance between bone resorption and bone formation. Numerous studies have investigated this issue, and many therapeutic agents have been proposed, including antiresorptives such as bisphosphonates, selective estrogen receptor modulator (SERM), and salmon calcitonin.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and anti-osteoporosis activity of novel Teriparatide glycosylation derivatives

Wang

Song

et al. 2020

RSC Adv.

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Prevalence of osteoporosis with the World Health Organization diagnostic criteria in the Eastern Mediterranean Region: a systematic review and meta-analysis

Cited by 47 publications

References 29 publications

Incidence of Hip Fracture in the Eastern Mediterranean Region- A Systematic Review and Meta-Analysis

Incidence of Hip Fracture in the Eastern Mediterranean Region- A Systematic Review and Meta-Analysis

Effects of Rambutan Peel (Nepheliumlappaceum) PhenolicExtract on RANKL-Induced Differentiation of RAW264.7 Cells into Osteoclasts and Retinoic Acid-Induced Osteoporosis in Rats

Synthesis and anti-osteoporosis activity of novel Teriparatide glycosylation derivatives

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