Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs

Wolf, Ursula; Eckert, Sandra van; Walter, Grit; Wienke, Andreas; Bartel, Susanne; Plontke, Stefan K.; Naumann, Christina

doi:10.1038/s41598-021-99858-w

Cited by 33 publications

(38 citation statements)

References 56 publications

(53 reference statements)

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“…The data collected in this study showed that in physiological (high level of ECM in control CPM) and pathological (excessive ECM deposition in OPMD CPM) human muscle fibrosis, the populations of FAPs involved were globally similar, indicating that TGFβ and ET‐1 are broadly implicated in human muscle fibrosis. It is known that increase in connective tissue can eventually lead to dysphagia in the elderly: dysphagia is known to affect about 15–30% of aged individuals 39 . In our observations, this connective tissue is increased in OPMD patients, and consequently, the fibrosis would have a negative effect causing a stiffening of the tissue and problems in deglutition.…”

Section: Discussionsupporting

confidence: 49%

“…It is known that increase in connective tissue can eventually lead to dysphagia in the elderly: dysphagia is known to affect about 15–30% of aged individuals. 39 In our observations, this connective tissue is increased in OPMD patients, and consequently, the fibrosis would have a negative effect causing a stiffening of the tissue and problems in deglutition. Further studies are needed to decipher specific changes in muscle‐associated fibrosis in pathological conditions like OPMD (Table S2 ).…”

Section: Discussionsupporting

confidence: 46%

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A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis

Bensalah

Muraine

Boulinguiez

et al. 2022

J cachexia sarcopenia muscle

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Background Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM) components. Many organs are subjected to fibrosis including the lung, liver, heart, skin, kidney, and muscle. Muscle fibrosis occurs in response to trauma, aging, or dystrophies and impairs muscle function. Fibrosis represents a hurdle for the treatment of human muscular dystrophies. While data on the mechanisms of fibrosis have mostly been investigated in mice, dystrophic mouse models often do not recapitulate fibrosis as observed in human patients. Consequently, the cellular and molecular mechanisms that lead to fibrosis in human muscle still need to be identified. Methods Combining mass cytometry, transcriptome profiling, in vitro co‐culture experiments, and in vivo transplantation in immunodeficient mice, we investigated the role and nature of nonmyogenic cells (fibroadipogenic progenitors, FAPs) from human fibrotic muscles of healthy individuals (FibM CT ) and individuals with oculopharyngeal muscular dystrophy (OPMD; FibM OP ), as compared with nonmyogenic cells from human nonfibrotic muscle (M CT ). Results We found that the proliferation rate of FAPs from fibrotic muscle is 3–4 times higher than those of FAPs from nonfibrotic muscle (population doubling per day: M CT 0.2 ± 0.1, FibM CT 0.7 ± 0.1, and FibM OP 0.8 ± 0.3). When cocultured with muscle cells, FAPs from fibrotic muscle impair the fusion index unlike M CT FAPs (myoblasts alone 57.3 ± 11.1%, coculture with M CT 43.1 ± 8.9%, with FibM CT 31.7 ± 8.2%, and with FibM OP 36.06 ± 10.29%). We also observed an increased proliferation of FAPs from fibrotic muscles in these co‐cultures in differentiation conditions (FibM CT +17.4%, P < 0.01 and FibM OP +15.1%, P < 0.01). This effect is likely linked to the increased activation of the canonical TGFβ‐SMAD pathway in FAPs from fibrotic muscles evidenced by pSMAD3 immunostaining ( P < 0.05). In addition to the profibrogenic TGFβ pathway, we identified endothelin as a new actor implicated in the altered cross‐talk between muscle cells and fibrotic FAPs, confirmed by an improvement of the fusion index in the presence of bosentan, an endothelin receptor antagonist (from 33.8 ± 10.9% to 52.9 ± 10.1%, P < 0.05). Conclusions Our data demonstrate the key role of FAPs and their cross‐talk with muscle cells through a paracrine signalling pathway in fibrosis of human skeletal muscle and identify endothelin as a new druggable target ...

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Section: Discussionsupporting

confidence: 49%

Section: Discussionsupporting

confidence: 46%

A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis

Bensalah

Muraine

Boulinguiez

et al. 2022

J cachexia sarcopenia muscle

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“…The diagnostic tool for OD in most studies was physical examination (12 articles) or volume–viscosity swallow test (10 articles). The highest quality assessment score based on the JBI checklist was related to the study of Wolf et al [ 23 ] with a score of 9. Table 2 represents the characteristics of studies included in the systematic review and meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The highest prevalence rate of OD (96%) was reported in the study of Almeida et al [ 22 ] and the lowest rate (7.3%) in the study of Watson and Lally [ 21 ]. The highest quality assessment score based on JBI checklist criteria was related to the study of Wolf et al [ 23 ], which reported the prevalence rate of OD as 29%.…”

Section: Discussionmentioning

confidence: 99%

The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis

et al. 2022

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Background Oropharyngeal dysphagia (OD) refers to any abnormality in the physiology of swallowing in the upper gastrointestinal tract, which leads to the related clinical complications, such as malnutrition, dehydration, and sever complication, such as aspiration pneumonia, suffocation, and eventually, premature death. The previous studies indicated a various range of prevalence of OD. The present systematic review and meta-analysis aimed to standardize the global prevalence of OD in different populations. Methods A systematic literature review was conducted using Embase, Scopus, PubMed, Web of Science (WoS) databases, and Google Scholar motor engine using related MeSH/Emtree and Free Text words, with no time limitation until November 2021. The heterogeneity among studies was quantified using I2 index and the random effects model was used, due to the high heterogeneity among the results of studies included in the meta-analysis. Results The systematic literature search retrieved 2092 studies. After excluding the irrelevant studies, ultimately 27 articles with a sample size of 9841 were included in the meta-analysis. After combining the studies, the overall estimate of the global prevalence rate of OD was 43.8% (95% CI 33.3–54.9%) and the highest prevalence rate was estimated in Africa with 64.2% (95% CI 53.2–73.9%). Given the subgroup analysis based on the study population, the highest prevalence of OD was related to Dementia with 72.4% (95% CI 26.7–95.0%). The results of meta-regression indicated that the prevalence of OD has an increasing trend with the enhancement of year of publication and mean age. Conclusion The results of the present systematic review and meta-analysis revealed that the prevalence of OD is high in different populations and its trend has been increasing in recent years. Therefore, the appropriate strategies should be applied to reduce the prevalence of OD by finding its causation and monitoring at all levels, as well as providing feedback to hospitals.

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“…Pharmacotherapy, however, produces limited results and should therefore not be used as a stand-alone treatment, but rather as an adjunct to other therapies [8] . Furthermore, medications such as antidopaminergic agents, anticholinergic drugs, or benzodiazepines induce or exacerbate dysphagia [9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Neurogenic dysphagia: current pharmacogenomic perspectives

Guerra¹,

Naidoo²,

Cacabelos³

2022

J Transl Genet Genom

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Neurogenic dysphagia (ND) is characterized by a swallowing disorder where nervous system, muscle, and neuromuscular diseases are involved. DRD1, COMT, BDNF, and APOE are genes that may have a predictive role in the occurrence and evolution of ND. Many drugs that improve swallowing or can induce or exacerbate swallowing difficulties are related to dopamine metabolism and substance P. These pharmacological treatments for ND include dopamine precursors (levodopa), dopamine agonists (amantadine, apomorphine, cabergoline, and rotigotine), and TRP channel activators (capsaicin, piperine, and menthol). Since treatment outcomes are highly dependent on the genomic profiles of ND patients, personalized treatments should rely on pharmacogenetic procedures to optimize therapeutic interventions. Knowledge of the pharmacogenetic profiles of these drugs would minimize the occurrence of adverse drug reactions (especially to antidopaminergic medications) that may induce dysphagia and optimize pharmacological treatment that can ameliorate it. This knowledge should also be applied to the use of medications that control symptoms associated with dysphagia, such as sialorrhea, xerostomia, reflux, or hiccups.

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Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs

Cited by 33 publications

References 56 publications

A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis

A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis

The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis

Neurogenic dysphagia: current pharmacogenomic perspectives

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