Prevalence of orofacial alterations in sickle cell disease: a review of literature

Santos, Poliana Ramos Braga; Machado, Paula Dioné Casais e Silva; Passos, Cristina Pinho; Aguiar, Marcio Cajazeira; Nascimento, Roberto José Meyer; Campos, Maria Isabela Guimarães

doi:10.1590/s1677-32252013000300001

Cited by 10 publications

(6 citation statements)

References 40 publications

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“…The link between these effects and PH has been confirmed by clinical and epidemiological studies (Caffey, ; Eng, ; Moseley, ; Ortner, ; Schultz, ; Stuart‐Macadam, ). In terms of skeletal samples, the state of cranial diploic bone in previously studied individuals with PH is described as either hypertrophic (Angel, ; Domínguez‐Rodrigo et al, ; Gowland and Western, ; Sullivan, ; Tayles, ; Walker et al, ; Wapler et al, ) or hyperplastic (Ascenzi, ; El‐Najjar et al, 1975; Filon, Faerman, Smith, & Oppenheim, ; Jatautis et al, ; Lagia, Eliopoulos, & Manolis, ; Lanzkowsky, ; Martin and Goodman, ; Moseley, ; Santos et al, ; Schultz, ; Stuart‐Macadam, ; Von Endt and Ortner, ; Walker, ; Walker et al, ; Williams, Lagundoye, & Johnson, 1975; Yildirim et al, ) due to an expanded diploë.…”

Section: Discussionmentioning

confidence: 99%

New evidence suggesting a dissociated etiology for cribra orbitalia and porotic hyperostosis

Rivera

Lahr

2017

American J Phys Anthropol

119

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Our results suggest a complex pattern of causality in relation to the pathologies that may lead to the formation of porotic lesions on the vault and the roof of the orbits. A form of anemia may be behind the osteological changes observed in PH and CO, but it is unlikely to be the same type of anemic condition that underlies both types of osteological lesions. We suggest that CO may be associated to anemias that lead to diploic bone hypocellularity and hypoplasia, such as those caused by anemia of chronic disease and, to a lesser extent, of renal failure, aplastic anemia, protein deficiency, and anemia of endocrine disorders, and not those that lead to bone marrow hypercellularity and hyperplasia and potential PH. This leads us to the conclusion that the terms PH and CO should be used to reflect different underlying conditions.

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Section: Discussionmentioning

confidence: 99%

New evidence suggesting a dissociated etiology for cribra orbitalia and porotic hyperostosis

Rivera

Lahr

2017

American J Phys Anthropol

119

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“…Caracas, et al reported a rare case of aseptic arthritis in the TMJ of a 22-year-old woman with SCD. The patient in this situation developed pain in the left preauricular region, hyperalgesia of the left masseter muscle, mouth opening limitation, and mild edema [31].…”

Section: Oral Mucosamentioning

confidence: 95%

Dental Alterations in Sickle Cell Disease

Al-Jafar¹,

Dashti²,

Sj³

et al. 2016

Journal of Dentistry and Oral Care Medicine

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“…In the calvarium the expanding bone marrow results in widening of the diploic space with thinning of the outer table. Perpendicular orientation of trabeculae to inner table gives a "hair-on-end" or "bristlelike" appearance [35], [71]. In a case-report by Acharya, the lateral skull radiograph of a 16-year old girl with SCD revealed thickened diploe and a ''hair-on-end pattern'' [39].…”

Section: F Malocclusion-facial Overgrowthmentioning

confidence: 99%

Sickle Cell Disease: An Overview of Oral Health Considerations for Pediatric Patients

Eleftherou

Arhakis

Davidopoulou

2021

EJDENT

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Aim: This literature review aims to update the evidence for orofacial manifestations and current treatment recommendations for children and adolescents with sickle cell disease. Background: Sickle cell disease is a frequent hemoglobinopathy and a life-threatening genetic disorder. The lifelong condition is characterized by chronic hemolytic anemia and vaso-occlusive crisis that may occur in a variable range of clinical presentations in different regions of the body, including the oral cavity. Review results: This review explored the most common orofacial alterations of pediatric patients with SCD. Dental caries is a common finding in SCD pediatric patients, especially in those who are socio-economically vulnerable. Moreover, malocclusions occur in high prevalence in SCD pediatric patients. Other oral health complications seen in SCD patients include periodontal inflammation, bone changes, infections, mental nerve neuropathy, facial overgrowth, delayed tooth eruption, dental anomalies, pulp necrosis, soft tissue alterations and salivary changes. Dental infections may trigger a vaso-occlusive crisis leading the patient to a higher probability on arriving in hospital emergency departments and in need for further hospital admission to deal with the correlated complications. Thus, preventive dental care and non-invasive dental procedures are the principal focus in SCD patients in order to avoid possible subsequent complications. Conclusion: The review showed that in pediatric patients with SCD the risk for orofacial manifestations and complications depends not only on the presence of SCD but also on other confounding factors such as oral hygiene, diet habits and social conditions. Moreover, more well-designed epidemiological studies are necessary to assess the real link between SCD disease and its impact on stomatognathic health.

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Prevalence of orofacial alterations in sickle cell disease: a review of literature

Cited by 10 publications

References 40 publications

New evidence suggesting a dissociated etiology for cribra orbitalia and porotic hyperostosis

New evidence suggesting a dissociated etiology for cribra orbitalia and porotic hyperostosis

Dental Alterations in Sickle Cell Disease

Sickle Cell Disease: An Overview of Oral Health Considerations for Pediatric Patients

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