Prevalence of Oral Lichen Planus in Diabetes Mellitus: a Meta-Analysis Study

Abstract

Background:Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM). This study evaluated the prevalence of OLP in DM patients compared with non-diabetic control subjects in a meta-analysis study.Methods:In this study from January 1973 to August 2016, we searched the studies in Web of Science, Medline/PubMed, Scopus, Science direct, SID (Scientific Information Database), Cochrane and Embase databases. Strategy search was the Medical Subject Heading (MeSH) term oral lichen planus or oral mucosa combined with diabetes in PubMed and this search in other databases. Heterogeneity between estimates was evaluated by the Q and I2 statistic. Also, publication bias was assessed through funnel plot analysis with the Kendall’s and Egger’s tests.Results:From 831 studies were identified with different search strategies, 11 studies met the criteria to be included in meta-analysis (11 case-control studies). The overall prevalence of OLP in 11 studies with 4937 DM patients and 3698 control subjectswas 1.5% and 0.75%, respectively. In this meta-analysis, the OR in prevalence of OLP in DM patients compared with control subjects was 1.584 (95%CI1.013-2.477; P=0.044) with a low level of heterogeneity (I2 = 0%) that the result showed the prevalence of OLP in DM patients is significantly more than control subjects.Conclusions:This meta-analysis study showed an association between OLP with DM, whereas this association was no significant in previous studies, it was probably because different selecting of age, sex, type of DM, medications and criteria. Totally, the meta-analysis showed the risk of OLP in DM was higher compared with control subjects.

Lichen planus and diabetes mellitus: Systematic review and meta‐analysis

“…Their results are similar to ours with a difference in heterogeneity which has been shown to be low in their study. A possible explanation for this fact is that a higher number of studies (11 studies in total) were analyzed in the meta-analysis performed by Mozaffari, Sharifi, and Sadeghi (2016).…”

Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case–control studies

“…Diabetes mellitus is a chronic condition with severe long-term, disabling complications, and unknown remedy that is characterized by disorders in carbohydrate, fat, and protein metabolism. [ 1 ] Prevalence of diabetes in the adult population is currently considered to be 6.4% in the world. [ 2 ] Type 2 diabetes (T2D) is caused primarily by insulin resistance in the liver, muscle, and adipose tissue as peripheral target organs.…”

Diabetes mellitus and hepatitis c in generalised lichen planus: a case control study

“…Studies have established that prevalence of OLP was higher in diabetic patients compared to control group. 13 It has been noted that the mean duration of DM was significantly higher than GLP in diabetic patients establishing that whether DM increases the risk of GLP and not viceversa. This can be explained that probably the risk of GLP increases in DM which share a common background of endocrinology and immunological dyfunction.…”