Prevalence of Oral Human Papillomavirus Infection among Youth, Sweden

Abstract

Human papillomavirus (HPV) causes cervical, head, and neck cancers. We studied 483 patients at a youth clinic in Stockholm, Sweden, and found oral HPV prevalence was 9.3% and significantly higher for female youth with than without cervical HPV infection (p = 0.043). Most oral HPV types matched the co-occurring cervical types.

Oral human papillomavirus (HPV) prevalence in youth and cervical HPV prevalence in women attending a youth clinic in Sweden, a follow up-study 2013–2014 after gradual introduction of public HPV vaccination

“…It involved 211 women and 87 men (aged 15-23 years) advised on birth control and sexually transmitted diseases at a youth clinic in Stockholm [3,4]. Data on HPv vaccination, but not in relation to sexual debut, were included.…”

“…Data on HPv vaccination, but not in relation to sexual debut, were included. HPv prevalence was compared between HPv-vaccinated and non-vaccinated women in this study, and to data for 2009-2011 on oral HPv prevalence from the same youth clinic [4].…”

“…both studies were initiated after HPv vaccination in 2007 became available at reduced cost for 13-17 year olds, but before 2010 when vaccination became free of charge for 10-12-year-old girls, and 2012 when it was introduced into the school-based vaccination program and was free of charge for girls up to 18 years [5]. In those studies, in non-vaccinated individuals, cervical HPv prevalence was  70%, while oral HPv prevalence was 9.3% and similar in men and women [3,4]. HPv prevalence, including HPv16, was high by international standards and especially interesting to follow, after the gradual introduction of public quadrivalent HPv vaccination, particularly in relation to recent studies at a high school in a middle-sized town in Sweden, where oral HPv prevalence was low (1.8%) [3,4,[6][7][8].…”

“…To develop effective vaccines and better predict the future burden of HPv-related cancers, it is useful to follow HPv prevalence in sexually active youth. In 2008-2010 and 2009-2011, we therefore examined HPv prevalence in youth aged 15-23 years attending a Stockholm youth clinic [3,4]. both studies were initiated after HPv vaccination in 2007 became available at reduced cost for 13-17 year olds, but before 2010 when vaccination became free of charge for 10-12-year-old girls, and 2012 when it was introduced into the school-based vaccination program and was free of charge for girls up to 18 years [5].…”

HPV-related oropharyngeal carcinoma

“…La prévalence de l'infection orale par l'HPV, tous génotypes confondus, est faible et variable selon les pays : 0,6 % au Japon, 6,99 % aux États-Unis et 9,3 % en Suède [11][12][13]. L'étude américaine portait sur 5 000 personnes.…”