Prevalence of oncogenic Human papillomavirus and genetic diversity in the L1 gene of HPV16 HPV 18 HPV31 and HPV33 found in women from Vojvodina Province Serbia

Kovačević, Gordana; Milosevic, Vesna; Knežević, Petar; Knežević, Aleksandra; Knežević, Ivana; Radovanov, Jelena; Nikolić, Nataša; Patić, Aleksandra; Petrović, Vladimir; Cvjetković, Ivana Hrnjaković; Stanisic, Ljiljana

doi:10.1016/j.biologicals.2019.02.001

Cited by 16 publications

(13 citation statements)

References 23 publications

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“…The overall HPV16+/18+ prevalence in our study was ~23%, which is similar to the findings in cervical cancer samples from the Croatian population (21%) [ 37 ]. HPVs 16, 31 and 18 were also the most common high-risk HPVs in cervical cancer samples in Serbian women [ 38 ]. In our study, the other expressed HPV-types included HPV−45, −51 and −52, which have been previously reported in cervical cancer in Bosnia [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status

et al. 2020

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Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes (e.g., viruses) in the pathogenesis of CRC is poorly understood. In the current study, we explored the status of high-risk human papillomaviruses (HPV) and Epstein–Barr virus (EBV) in a well-defined CRC cohort using immunohistochemistry and polymerase chain reaction assays. Our data showed that high-risk HPVs were common (~80%) and EBV had a low presence (14–25%) in the CRC samples. The most common high-risk HPVs are HPV16, 31, 18, 51, 52 and 45 genotypes. The co-presence of high-risk HPV and EBV was observed in ~16% of the sample population without any significant association with the clinicopathological variables. We conclude that high-risk HPVs are very prevalent in CRC samples while EBV positivity is relatively low. The co-expression of the two viruses was observed in a minority of cases and without any correlation with the studied parameters. Further studies are necessary to confirm the clinical relevance and potential therapeutic (preventive) effects of the observations reported herein.

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Section: Discussionmentioning

confidence: 99%

High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status

et al. 2020

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“…Viral DNA of these high-risk strains nowadays can be easily detected in exfoliated cervical cells using commercially available tests [12]. This HPV test represents a convenient, highly sensitive screening tool that is rapidly becoming a part of screening guidelines of many countries and has a tendency of becoming the main screening method [13].…”

Section: Introductionmentioning

confidence: 99%

“…This HPV test represents a convenient, highly sensitive screening tool that is rapidly becoming a part of screening guidelines of many countries and has a tendency of becoming the main screening method [13]. Still, it has an important flaw and that is its lower specificity [12]. Apart from this, there is also the well-known Pap smear screening method.…”

Section: Introductionmentioning

confidence: 99%

Knowledge about Cervical Cancer and Awareness of Human Papillomavirus (HPV) and HPV Vaccine among Female Students from Serbia

Rančić

Golubović

Ilić³

et al. 2020

Medicina

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Background and objectives: Persistent infection with carcinogenic human papillomavirus (HPV) is the leading cause of cervical cancer. The study explored students’ knowledge about cervical cancer and awareness of human papillomavirus and the HPV vaccine. Materials and Methods: A questionnaire-based survey was carried out among 1616 first-year female college students at the University of Niš. It examined socio-demographic characteristics, measured the score of knowledge about cervical cancer, assessed awareness regarding HPV and the HPV vaccine and inquired about the source of information about cervical cancer and HPV. Results: The average cervical cancer knowledge score was 16.35 ± 7.92 (min 0, max 30), with medical professional education, parents’ education level, place of residence and relationship status having significant effects on the score. The awareness about HPV and the HPV vaccine was low, with only 14.2% of students having heard about both HPV and its vaccine. The most commonly reported sources of information were the media, while the most competent one was organized health education. Conclusions: Health promotion campaigns and educational programs are necessary in order to reduce cervical cancer burden and should be directed particularly towards those who have demonstrated low cervical cancer knowledge and low awareness regarding HPV and its vaccine.

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“…36 Indeed, one of the key findings in our study is the predominance of HPV genotypes 52 and 45 followed by 31, 58, and 68 in TNBC samples from Croatian women. It is important to emphasize that HPV types 16 and 18 are the most frequently expressed genotypes in cancers worldwide; 57,58,71,72 in Croatia as well, the most prevalent subtype in cervical cancer was HPV16 (44%), followed by HPV18 (39%), HPV51 (18%), HPV31 (11%), HPV33 (8%), and HPV45 (3%). 73 Another study in cervical cancer by Sabol et al, found HPV16 as the most prevalent type (61%), followed by HPV18 (10%), HPV31 (4%), HPV33 (4%), HPV35 (2%), HPV45 (6%), HPV52 (3%) and HPV58 (2%).…”

Section: Discussionmentioning

confidence: 99%

Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer

Gupta

Ulamec

Perić-Balja

et al. 2021

Human Vaccines & Immunotherapeutics

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Breast cancer, the most frequent disease amongst women worldwide, accounts for the highest cancerrelated mortality rate. Triple-negative breast cancer (TNBC) subtype encompasses ~15% of all breast cancers and lack estrogen, progesterone, and HER2 receptors. Although risk factors for breast cancer are well-known, factors underpinning breast cancer onset and progression remain unknown. Recent studies suggest the plausible role of oncoviruses including human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus (MMTV) in breast cancer pathogenesis. However, the role of these oncoviruses in TNBC is still unclear. In the current study, we explored the status of high-risk HPVs, EBV, and MMTV in a well-defined TNBC cohort from Croatia in comparison to 16 normal/non TNBC samples (controls) using polymerase chain reaction assay. We found high-risk HPVs and EBV present in 37/70 (53%) and 25/70 (36%) of the cases, respectively. The most common HPV types are 52, 45, 31, 58 and 68. We found 16% of the samples positive for co-presence of high-risk HPVs and EBV. Moreover, our data revealed that 5/70 (7%) samples are positive for MMTV. In addition, only 2/70 (3%) samples had copresence of HPVs, EBV, and MMTV without any significant association with the clinicopathological variables. While, 6/16 (37.5%) controls were positive for HPV (p = .4), EBV was absent in all controls (0/ 16, 0%) (p = .01). In addition, we did not find the co-presence of the oncoviruses in the controls (p > .05). Nevertheless, further investigations are essential to understand the underlying mechanisms of multipleoncogenic viruses' interaction in breast carcinogenesis, especially TNBC.

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Prevalence of oncogenic Human papillomavirus and genetic diversity in the L1 gene of HPV16 HPV 18 HPV31 and HPV33 found in women from Vojvodina Province Serbia

Cited by 16 publications

References 23 publications

High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status

High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status

Knowledge about Cervical Cancer and Awareness of Human Papillomavirus (HPV) and HPV Vaccine among Female Students from Serbia

Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer

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