Prevalence of occult hepatitis B in a population from the Brazilian Amazon region

Anna, Carla de Castro Sant’; Almeida, Marcella Kelly Costa de; Ferreira, Paulo Vítor Campos; Oliveira, Roseane Gomes de; Baraúna, Anna Rafaella Ferreira; Goncalvez, E; Silva, Andrea Marinho da; Pereira, Carolina de Souza; Martins, Luisa Carí­cio

doi:10.1002/jmv.25051

Cited by 10 publications

(11 citation statements)

References 47 publications

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“…A very similar prevalence was found by Mello and colleagues [54] in a survey on the phylogeography of HBV/F in Brazil, in which HBV/F2 was suggested as being the oldest HBV/F subgenotype, thus representing the original native HBV of Brazil [54]. HBV/F2 have been described in variable proportions across Brazil [16,39,55,56]. Here, HBV/F2 was mostly found in North and Northeast displaying high similarity with other Brazilian sequences and with sequences from Venezuela.…”

Section: Discussionsupporting

confidence: 64%

Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil

Lago

Espírito-Santo

Costa

et al. 2019

Viruses

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Hepatitis B virus (HBV) subgenotypes may be related to clinical outcomes and response to antiviral therapy. Most Brazilian studies on HBV subgenotypes are restricted to some regions and to specific population groups. Here, we provide an insight about genetic diversity of HBV subgenotypes in 321 serum samples from all five geographical regions, providing a representative overview of their circulation among chronic carriers. Overall, HBV/A1 was the most prevalent subgenotype, being found as the major one in all regions except in South Brazil. Among HBV/D samples, subgenotype D3 was the most prevalent, found in 51.5%, followed by D2 (27.3%) and D4 (21.2%). D2 and D3 were the most prevalent subgenotypes in South region, with high similarity with European strains. D4 was found in North and Northeast region and clustered with strains from Cape Verde and India. For HBV/F, the most frequent subgenotype was F2 (84.1%), followed by F4 (10.1%) and F1 (5.8%), closely related with strains from Venezuela, Argentina and Chile, respectively. Phylogeographic analyses were performed using an HBV full-length genome obtained from samples infected with genotypes rarely found in Brazil (B, C, and E). According to Bayesian inference, HBV/B2 and HBV/C2 were probably introduced in Brazil through China, and HBV/E from Guinea, all of them mostly linked to recent events of human migration. In conclusion, this study provided a comprehensive overview of the current circulation of HBV subgenotypes in Brazil. Our findings might contribute to a better understand of the dynamics of viral variants, to establish a permanent molecular surveillance on the introduction and dispersion patterns of new strains and, thus, to support public policies to control HBV dissemination in Brazil.

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Section: Discussionsupporting

confidence: 64%

Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil

Lago

Espírito-Santo

Costa

et al. 2019

Viruses

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“…Recently, another study performed in Para found the genotypes A and F as the predominant ones in these populations. Genotype A was the most frequentwith 88.46%, and among the subgenotypes, AI represented 78.26%, followed by A2 21.74% and the prevalence of genotype F was 11.54% 33 .…”

Section: Discussionmentioning

confidence: 94%

Phylogenetic analysis and genotype distribution of Hepatitis B Virus (HBV) in Roraima, Brazil

Sousa

Silva

Lima

et al. 2018

Rev. Inst. Med. trop. S. Paulo

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Hepatitis B virus (HBV) infection is a serious global health problem. HBV has a high viral genetic diversity, with 10 genotypes recognized. In Brazil, the Roraima State is the third in the Northern region regarding the number of hepatitis B cases. On the other hand, few data on HBV genotyping and phylogenetic analysis are available. The purpose of this study is to characterize the HBV genotypes circulating in Roraima State. Of the 113 chronic hepatitis B patients enrolled in this study, 40 were HBV-DNA positive. A fragment of 280 bp (S gene) was amplified by PCR and submitted to nucleotide sequencing. A dataset containing the viral sequences obtained in this study, plus 130 obtained from GenBank was used for genotyping by phylogenetic analysis. The HBV subgenotype distribution found was A1 (62.5%), A2 (7.5%), D2, D3, D4 (2.5%), F2a (12.5%), and F3 (10%). We characterized the genotypes and subgenotypes of HBV circulating among patients in the State of Roraima. In addition, our study shows for the first time the HBV/F3 genotype circulating in Brazil. In conclusion, our findings showed a high diversity of HBV genotypes in Roraima, which is also found in other Brazilian geographical regions.

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“…A high prevalence of occult HBV infection was also observed in a study conducted in a Brazilian Amazonian population in which HBV DNA was found in 14.36% of the patients. 5 In the Maraj o Archipelago, occult HBV infection was also observed among illicit drug users, whose prevalence was 4.6%. 9 Occult HBV infection is a warning to health authorities, because these asymptomatic carriers contribute to the spread of the virus in the region.…”

Section: Discussionmentioning

confidence: 99%

“…3 Furthermore, a number of previous studies have shown that genotype A is the most frequent in most Brazilian populations, including the riverside and indigenous communities from northern Brazil. [4][5][6] HBV can be transmitted through parenteral, perinatal, and sexual routes. 1,2,7,8 A number of different behaviors represent risk factors associated with the different HBV transmission routes, and the most vulnerable groups are sex workers, healthcare professionals, hemodialysis and blood transfusion patients, men who have sex with men, and illicit drug users.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and genotyping of hepatitis B virus: a cross-sectional study conducted with female sex workers in the Marajó Archipelago, Brazil

et al. 2019

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In South America, the Amazon basin is considered an endemic area of hepatitis B virus (HBV) infection. However, epidemiological studies with vulnerable groups are scarce. Female sex workers (FSWs) are highly vulnerable to sexually transmitted infections due to a combination of their sexual behavior and socio-economic conditions. Thus, this study investigated the prevalence of HBV infections and HBV–hepatitis C virus, HBV–hepatitis D virus, HBV–HIV, and HBV–human T-lymphotropic virus co-infections among FSWs in the Marajó Archipelago, northern Brazil, as well as identifying the HBV genotypes circulating in this population. A total of 153 FSWs in 5 towns and 18 riverside communities were included in the study. The HBV infection and co-infections were diagnosed by enzyme-linked immunosorbent assay and real-time polymerase chain reaction. The HBV genotypes were detected by sequencing and were then analyzed phylogenetically. Most of the FSWs surveyed were single, young, heterosexual, and born locally, with low levels of education. Overall, 21 (13.7%) had been exposed to HBV, and HBV-DNA was detected in 13 (8.5%). Genotypes A (69.2%), D (23.1%), and F (7.7%) were detected. Seven cases of co-infections with other viruses were detected. These findings indicate a clear need for urgent measures to control the spread of HBV and other pathogens, and to promote the health of the local FSWs.

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Prevalence of occult hepatitis B in a population from the Brazilian Amazon region

Cited by 10 publications

References 47 publications

Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil

Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil

Phylogenetic analysis and genotype distribution of Hepatitis B Virus (HBV) in Roraima, Brazil

Prevalence and genotyping of hepatitis B virus: a cross-sectional study conducted with female sex workers in the Marajó Archipelago, Brazil

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