Prevalence of nonalcoholic fatty liver disease in normal-weight and overweight preadolescent children in Haryana, India

Das, Manoj; Bhatia, Vidyut; Sibal, Anupam; Gupta, Ajay; Gopalan, Sarath; Sardana, Raman; Sahni, Reeti; Roy, Ankur; Arora, Narendra K.

doi:10.1007/s13312-017-1202-3

Cited by 16 publications

(17 citation statements)

References 19 publications

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“…documented NAFLD as 26% in obese children and 45.6% in overweight, respectively. [ 2 7 ] The range of prevalence of NAFLD found in obese children in other developed countries varied widely from 26.0% to 85% in studies done by Yu et al . and Jimenez-Rivera et al .…”

Section: Discussionmentioning

confidence: 99%

“…Sample size was calculated using the formula: n = z 2 P (1 − p )/ d 2 . [ 7 ] The prevalence of pediatric NAFLD in overweight children had been estimated as about 45.6% as per an Indian study done in Haryana. [ 7 ] Considering an absolute margin of error of 10% at 95% confidence interval with 90% power, the total sample size was 100.…”

Section: Methodsmentioning

confidence: 99%

“…[ 7 ] The prevalence of pediatric NAFLD in overweight children had been estimated as about 45.6% as per an Indian study done in Haryana. [ 7 ] Considering an absolute margin of error of 10% at 95% confidence interval with 90% power, the total sample size was 100. We enrolled consecutive 100 patients who fulfilled the inclusion criteria from the database for the study.…”

Section: Methodsmentioning

confidence: 99%

“…There are limited data on the prevalence and other aspects of this disease from the developing world, particularly from India. [ 2 6 7 ] In recent studies from India, a wide ranging prevalence of 26%–62.5% using ultrasonography (USG) as a diagnostic tool has been reported of pediatric NAFLD in obese children. [ 2 6 ] A high proportion of overweight children with fatty liver on ultrasound indicates the increasing burden of this disease in the Indian pediatric population.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and risk factors for nonalcoholic fatty liver disease in obese children in rural Punjab, India

Gupta¹,

Jindal²,

Nadda³

et al. 2020

J Fam Community Med

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BACKGROUND: Pediatric nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance, hypertension, metabolic syndrome, cardiovascular problems, and increased risk of chronic liver disease and Type II diabetes mellitus. The aim of the study was to assess the metabolic profiles and associated risk factors of NAFLD in obese children. MATERIALS AND METHODS: Children with a body mass index (BMI) of >27 kg/m 2 an adult equivalent cutoff (Indian Academy of Paediatrics, 2015 guidelines) aged 5–18 years presenting to the pediatric outpatient unit of PGIMER Satellite Centre, Sangrur, India, were retrospectively recruited over a 1-year period. Anthropometry, lipid profile, thyroid levels, liver function test, fasting blood sugar, and blood pressure were measured. Ultrasonography was used to diagnose NAFLD. Logistic regression was used to assess the risk factors. RESULTS: A total of 100 children participated in the study. The mean age was 10.6 ± 2.6 years and the mean BMI-Z score was 2.6 ± 0.5. The prevalence of NAFLD was 62%. Alanine transaminase (ALT) was significantly elevated in all the children with NAFLD. Lipid levels and BMI Z-score were similar in both groups. Unadjusted odds ratio shows statistically significant association of ALT (2.058 [1.11–1.01]) and waist circumference (1.089 [1.19–0.99]) with NAFLD. With adjusted odds ratio only, ALT (1.12 [1.24–1.01]) was found to be significantly associated with NAFLD. CONCLUSION: There is quite a high prevalence of nonalcoholic fatty liver in obese Indian children. All children with raised liver enzymes should undergo sonography to rule out NAFLD.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence and risk factors for nonalcoholic fatty liver disease in obese children in rural Punjab, India

Gupta¹,

Jindal²,

Nadda³

et al. 2020

J Fam Community Med

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“…The prevalence of fatty liver appears to differ, however, across global populations, including Asia (10.2%) [9] and Europe (2.5%) [12] . Jain (2019) also demonstrated this point in a recent dissertation [13] , and different countries also have different prevalence rates; for example, in Haryana, India, 22.4% of children aged 5-10 years had fatty liver [14] . The average prevalence of fatty liver in Chinese children has been estimated at 9.03% [15] .…”

Section: Discussionmentioning

confidence: 88%

Prevalence and Risk Factors of Metabolic-Associated Fatty Liver Disease in School-Age Children and Adolescents in Shenyang, China

Lin

Zhang

Tian

et al. 2020

Preprint

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Background: Metabolic-associated fatty liver disease (MAFLD) refers to abnormal accumulation of fat in the liver for metabolic dysfunction. With modern socioeconomic conditions and changes in dietary patterns, the prevalence of MAFLD is increasing, to the detrimental of children’s learning and quality of life. We investigated the prevalence and influencing factors of metabolic-associated fatty liver disease (MAFLD) in school-aged children and adolescents in Shenyang, China. Methods: In 2019, we collected demographic, anthropometric and liver health assessments from a random sample of Shenyang’ s school-aged children (7-12 years old) and adolescents (13-18 years old). Experienced hepatologists used transient elastography to diagnose the presence of fatty liver in the students. A random subsample was selected to complete a questionnaire to explore the impact of lifestyle habits on fatty liver disease.Results: The overall prevalence of MAFLD in these students was 23.83%, with a non-significant difference between children (22.73%) and adolescents (24.43%). The prevalence of MAFLD was significantly higher among boys than among girls. Compared with non-overweight students, a significantly higher proportion of the overweight group had fatty liver. Moreover, questionnaire responses on exercise habits, normal diet, and parental factors were associated with fatty liver.Conclusions: MAFLD is very prevalent in children and adolescents in Shenyang city. Due to the close relationship between MAFLD and obesity, lifestyle plays a major role in the occurrence of MAFLD.Trial registration: the First Affiliated Hospital of China Medical University, [2020]2020-258-2. Registered 6 June 2020 - Retrospectively registered.

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Pediatric Liver Disease in India

Shanmugam

Sathyasekaran

Rela

2021

Clinical Liver Disease

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Prevalence of nonalcoholic fatty liver disease in normal-weight and overweight preadolescent children in Haryana, India

Cited by 16 publications

References 19 publications

Prevalence and risk factors for nonalcoholic fatty liver disease in obese children in rural Punjab, India

Prevalence and risk factors for nonalcoholic fatty liver disease in obese children in rural Punjab, India

Prevalence and Risk Factors of Metabolic-Associated Fatty Liver Disease in School-Age Children and Adolescents in Shenyang, China

Pediatric Liver Disease in India

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