Prevalence of nonalcoholic fatty liver disease in mainland of <scp>C</scp>hina: A meta‐analysis of published studies

Li, Zhan-Zhan; Xue, Jing; Chen, Peng; Chen, Lizhang; Yan, Shipeng; Liu, LiYa

doi:10.1111/jgh.12428

Cited by 195 publications

(166 citation statements)

References 23 publications

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“…The prevalence of non-alcoholic fatty liver disease (NAFLD) in the general population is growing worldwide: 44% in the USA, 33% in Europe and 25% in Italy [1][2][3][4][5][6]; for non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, the estimate is 2-3% [3,5]. A large cohort study reported that NAFLD was associated with 26% higher 5-year overall health-care costs, mainly from cardiometabolic diseases [6].…”

Section: Introductionmentioning

confidence: 99%

A “systems medicine” approach to the study of non-alcoholic fatty liver disease

Petta

Valenti

Bugianesi

et al. 2016

Digestive and Liver Disease

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The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients.

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Section: Introductionmentioning

confidence: 99%

A “systems medicine” approach to the study of non-alcoholic fatty liver disease

Petta

Valenti

Bugianesi

et al. 2016

Digestive and Liver Disease

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“…Additionally, the prevalence is higher than 70% in subjects suffering from conditions associated with insulin resistance, such as obesity, type 2 diabetes, dyslipidemia, hypertension and MetS [13,14]. However, prospective cohort studies measuring the association between MetS and NAFLD in China's population are scarce.…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and its components as predictors of nonalcoholic fatty liver disease in a northern urban Han Chinese population: A prospective cohort study

Zhang

et al. 2015

Atherosclerosis

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“…Meta-analyses DOI: 10.1159/000497228 have reported the prevalence of NAFLD as 25.2% globally and 20.9% in the Chinese population [1,2], and NAFLD is recognized as a major current health burden. However, the pathogenesis of NAFLD remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Circulating Iron Levels Interaction with Central Obesity on the Risk of Nonalcoholic Fatty Liver Disease: A Case–Control Study in Southeast China

et al. 2019

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Objectives: We aimed to evaluate the associations between body iron stores and the risk of nonalcoholic fatty liver disease (NAFLD) in a Chinese population and explore whether this effect may be modified by other factors. Methods: A 1: 1 frequency-matched case–control study was conducted, including 482 NAFLD cases and 490 gender- and age-matched controls. Serum levels of ferritin, hepcidin, and C-reactive protein were measured. Results: Multivariate logistic regression analysis showed that hepcidin was not associated with NAFLD risk; however, elevated serum ferritin was significantly associated with increased risk of NAFLD (adjusted OR 1.619, 95% CI 1.158–2.267), and hepcidin:ferritin ratio was significantly associated with decreased risk of NAFLD (OR_adjusted 0.702, 95% CI 0.501–0.984). When stratified by gender, a significant association was found between elevated serum ferritin and hepcidin:ferritin ratio and NAFLD only for women (OR_adjusted 2.131, 95% CI 1.151–3.944 and OR_adjusted 0.414, 95% CI 0.219–0.781, respectively). A significant multiplicative interaction between central obesity and elevated serum hepcidin was observed (p < 0.05). Conclusions: Elevated serum ferritin and hepcidin:ferritin ratio are associated with NAFLD in a Chinese population. Although serum hepcidin is not associated with NAFLD, it may augment the risk effect of central obesity on NAFLD.

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Prevalence of nonalcoholic fatty liver disease in mainland of China: A meta‐analysis of published studies

Cited by 195 publications

References 23 publications

A “systems medicine” approach to the study of non-alcoholic fatty liver disease

A “systems medicine” approach to the study of non-alcoholic fatty liver disease

Metabolic syndrome and its components as predictors of nonalcoholic fatty liver disease in a northern urban Han Chinese population: A prospective cohort study

Circulating Iron Levels Interaction with Central Obesity on the Risk of Nonalcoholic Fatty Liver Disease: A Case–Control Study in Southeast China

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