Prevalence of newly established thyroid disorders in patients with moderate-to-severe obstructive sleep apnea syndrome

Bruyneel, Marie; Veltri, Flora; Poppe, Kris

doi:10.1007/s11325-018-1746-z

Cited by 23 publications

(20 citation statements)

References 32 publications

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“…Bielicki et al ( 17 ) indicated that although hypothyroidism may be a contributing, if not causal, component of OSA for some patients, most patients with OSA have normal thyroid function or do not have improvement in sleep symptoms with thyroid treatment. In fact, many studies, including one by Bruyneel et al ( 18 ), showed that TSH and T4 levels were not significantly different among patients with moderate or severe OSA, suggesting that thyroid hormone levels are not necessarily a marker of OSA severity. Similarly, Mete et al ( 14 ) assessed 150 patients with polysomnographically diagnosed OSA (50 mild, 50 moderate, and 50 severe OSA cases) and showed no significant association between OSA severity and thyroid hormone levels.…”

Section: Obstructive Sleep Apneamentioning

confidence: 99%

Thyroid Dysfunction and Sleep Disorders

Green

Bernet²,

Cheung³

2021

Front. Endocrinol.

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Thyroid disorders and sleep disorders are common problems in the general population that can affect people of all ages, backgrounds, and sexes, but little is known about their clinical associations. We reviewed the literature assessing the associations between thyroid disease and sleep disorders and noted that hyperthyroidism and hypothyroidism have clinical overlap with sleep conditions such as insomnia, restless legs syndrome, and obstructive sleep apnea. These findings highlight the importance of identifying and managing thyroid dysfunction for patients with these common sleep disorders. Additional research is needed to further understand how thyroid dysfunction affects sleep physiology.

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Section: Obstructive Sleep Apneamentioning

confidence: 99%

Thyroid Dysfunction and Sleep Disorders

Green

Bernet²,

Cheung³

2021

Front. Endocrinol.

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“…In addition, for practical reasons, we based the diagnosis of GIT on HbA1c only (and not on repeated abnormal glucose level measurements [19]), leading to a potential underestimation of GIT cases. This very high proportion of GMD in our cohort of mainly severe obese OSAS reflects a lack of medical attention to comorbidities in this population, known to suffer from frequent cardiometabolic and obesity-related conditions [3,5,6,20].…”

Section: Discussionmentioning

confidence: 88%

Prevalence of undiagnosed glucose intolerance and type 2 diabetes in patients with moderate-to-severe obstructive sleep apnea syndrome

2019

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Purpose Overweight and obesity are major causal factors for obstructive sleep apnea syndrome (OSAS), providing insight into why one third of patients with OSAS suffer from diabetes mellitus and another third from glucose intolerance. However, a significant proportion of the general population remains undiagnosed for glucose metabolism disorders. The primary aim of this study was to establish the prevalence of known and newly diagnosed glucose metabolism disorders in patients with moderate and severe OSAS referred to the sleep lab for continuous positive airway pressure (CPAP) therapy. Methods We prospectively included consecutive patients with moderate or severe OSAS referred for CPAP therapy. A fasting blood sample was collected to determine glycosylated hemoglobin (HbA1c), glucose, and homeostatic model assessment (HOMA) index. Baseline demographic data and medication intake were recorded. Results Of 280 consecutive patients (70% men, mean ± SD body mass index 33 ± 7 kg/m 2 , apnea-hypopnea index 49 ± 25), 22% exhibited diabetes and 44% glucose intolerance. Undiagnosed diabetes and glucose intolerance was found in 79 of 280 patients (28%). Insulin resistance was associated with OSAS severity in multivariate linear regression analysis (regression coefficient 2.40 [95% CI 0.07-4.72]; p = 0.04). Conclusion In this population of overweight and obese patients with moderate and severe OSAS, 66% of patients had diabetes or glucose intolerance and 28% were newly diagnosed. Diabetes and glucose intolerance were not related to OSAS severity, contrary to insulin resistance. These data suggest that there is value in systematic screening for glucose metabolism disorders in all patients with moderate and severe OSAS.

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“…There is a high (>20%) prevalence of hypothyroidism in patients with T2DM, hypertension, and patients having both [189]. Hypothyroidism can directly cause obstructive sleep apnea (OSA) [190,191], Bruyneel et.al, 2019 reported 16% of OSA patients had a thyroid problem and 8% of these were newly diagnosed with subclinical hypothyroidism (SCH) [192], over 50% of the patients studied did not receive any treatment, found in a recent…”

Section: Thyroid Disordersmentioning

confidence: 96%

Clinical Pharmacists in Chronic Care [Part 2]

Mohiuddin¹

2020

ABEB

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This work is licensed under Creative Commons Attribution 4.0 License ABEB.MS.ID.000566.Background Clinical pharmacology is a professional discipline that combines basic pharmacology and clinical medicine. A clinical pharmacist offers invaluable support in the development of a final prescription with better patient management and enhanced safety [1]. Its development began in the early 1950s, primarily as a result of the efforts of Harry Gold. Pharmacist rounding with inpatient hospital services has been traced to the University of Kentucky in 1957 [1,2]. Drug therapy was becoming much more complex. Graham Calder pioneered a new role for pharmacists on hospital wards in Aberdeen [3]. The role of clinical pharmacists underwent significant changes from the 1960s through 1990s as their participation in direct patient care enhanced. In the early 1970s, federal funding assisted with greatly expanding clinical pharmacy faculty in Colleges of Pharmacy [4]. Pharmacy education debated where clinical pharmacy fit within pharmacy training.The AACP spearheaded an effort to examine this issue. Till then, two full generations of pharmacists have been educated and trained after the general adoption of the aims of clinical pharmacy

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Prevalence of newly established thyroid disorders in patients with moderate-to-severe obstructive sleep apnea syndrome

Cited by 23 publications

References 32 publications

Thyroid Dysfunction and Sleep Disorders

Thyroid Dysfunction and Sleep Disorders

Prevalence of undiagnosed glucose intolerance and type 2 diabetes in patients with moderate-to-severe obstructive sleep apnea syndrome

Clinical Pharmacists in Chronic Care [Part 2]

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