Prevalence of neuropathic pain in early multiple sclerosis

Heitmann, Henrik; Biberacher, Viola; Tiemann, Laura; Buck, Dorothea; Loleit, Verena; Selter, Rebecca C; Knier, Benjamin; Tölle, Thomas R.; Mühlau, Mark; Berthele, Achim; Hemmer, Bernhard; Ploner, Markus

doi:10.1177/1352458515613643

Cited by 48 publications

(27 citation statements)

References 37 publications

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“…Depressed PwMS are more likely to have pain and there is a positive association between the interference of painful symptoms, and pain severity, with depression severity [4]. Pain, fatigue, and depression are interdependently associated and potentially modifiable [5]. Thus, improving pain symptoms may improve fatigue and depression, which would contribute to an improved quality of life.…”

Section: To the Editormentioning

confidence: 99%

Transcranial direct current stimulation (tDCS) for the treatment of a Multiple Sclerosis symptom cluster

2020

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Section: To the Editormentioning

confidence: 99%

Transcranial direct current stimulation (tDCS) for the treatment of a Multiple Sclerosis symptom cluster

2020

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“… 150 The most commonly accepted hypothesis is that autoimmune inflammation leads to demyelination through the activation of T cells which cross the blood brain barrier and induce the demyelination via release of cytokines and other factors. 151 , 152 Pain is a common symptom in MS and may be of nociceptive or neuropathic in origin, 153 , 154 although central neuropathic pain is most often reported. 155 …”

Section: Immune System Involvement In Chronic Conditionsmentioning

confidence: 99%

Immune system involvement in specific pain conditions

2017

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Chronic pain is a significant problem worldwide and is the most common disability in the United States. It is well known that the immune system plays a critical role in the development and maintenance of many chronic pain conditions. The involvement of the immune system can be through the release of autoantibodies, in the case of rheumatoid arthritis, or via cytokines, chemokines, and other inflammatory mediators (i.e. substance P, histamine, bradykinin, tumor necrosis factor, interleukins, and prostaglandins). Immune cells, such as T cells, B cells and their antibodies, and microglia are clearly key players in immune-related pain. The purpose of this review is to briefly discuss the immune system involvement in pain and to outline how it relates to rheumatoid arthritis, osteoarthritis, fibromyalgia, complex regional pain syndrome, multiple sclerosis, and diabetic neuropathy. The immune system plays a major role in many debilitating chronic pain conditions and we believe that animal models of disease and their treatments should be more directly focused on these interactions.

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“…Patients with traumatic medullary injuries develop NP in up to 70% of cases and pain is in general absent in the initial phase, appearing days or weeks after, and in 70% of these patients, pain persists after one year 54,55 . Central pain is developed in 44% of patients with brain stem infarcts and in syringomyelia this pain is prevalent in 75% of patients 56,57. In multiple sclerosis, central pain is prevalent in 28% of patients, however a study using the PainDETECT questionnaire to evaluate 377 ambulatory patients with early multiple sclerosis has evidenced NP in 4.2% of patients 2,58 .…”

Section: Central Neuropathic Painmentioning

confidence: 99%