Prevalence of Neuropathic Pain and Related Characteristics in Hidradenitis Suppurativa: A Cross-Sectional Study

Garcovich, Simone; Muratori, Simona; Moltrasio, Chiara; Buscemi, Agata Alba; Giovanardi, Giulia; Malvaso, Dalma; Stasio, Enrico Di; Marzano, Angelo Valerio; Peris, Ketty

doi:10.3390/jcm9124046

Cited by 12 publications

(25 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the recall capacity, patient education also plays a role: Patients with less than high school education recall 38% of items accurately, while patients with a college degree recall a significantly higher rate (65%) 31 . Moreover, recall of skin damage‐induced (nociceptive) pain is complicated by the presence of chronic central sensitization (neuropathic pain), which arises from dysregulation of the damage‐reporting system, namely the central nervous system, in chronic diseases 32,33 . The painDETECT questionnaire and the VAS and NRS pain in daily, weekly or monthly intervals have been included in clinical studies, all with the disadvantage of symptom severity recall by patients.…”

Section: How To Make Patient‐assessed Outcomes Reliablementioning

confidence: 99%

New treatments and new assessment instruments for Hidradenitis suppurativa

Straalen

Ingram

Augustin

et al. 2022

Experimental Dermatology

View full text Add to dashboard Cite

Hidradenitis Suppurativa is a chronic, debilitating inflammatory skin disease which affects around 1% of the Western population. 1 Research interest in this disease has grown exponentially over the past decades. With the increasing number of clinical trials in HS come new insights into the drawbacks of existing investigator assessed and patients reported outcomes. Moreover, the development of several international clinical registries highlights the need for the implementation of (different) outcome measures in routine clinical care. This article provides an overview of the latest developments in both investigator and patient-reported outcomes for HS as discussed during the 11th EHSF Conference in 2022.

show abstract

Section: How To Make Patient‐assessed Outcomes Reliablementioning

confidence: 99%

New treatments and new assessment instruments for Hidradenitis suppurativa

Straalen

Ingram

Augustin

et al. 2022

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…Pain, drainage and itching are the symptoms, which patients with HS consider play a central role in the reduction of their quality of life. Pain can be classified into two types, a nociceptive, acute skin pain, which correlates well with the severity of skin lesions, 3,4 and a chronic central sensitization, which some patients call pain, and is associated with their overall performance not only due to HS 5,6 …”

Section: Rsa Pain Nrs Ihs4 Hs‐pga Dlqimentioning

confidence: 99%

“…5,6 Although acute skin pain could become a well-established patient-reported outcome measure instrument, few studies have evaluated its impact in a reproducible, as objective as possible, manner. 4,5 The retrospective visual analogue scale of pain in daily, weekly or monthly intervals has been included in clinical studies 7 with the intrinsic disadvantage of exact symptom severity recalling by the patients. In addition, the chronic central sensitization worsens the capacity of acute pain recall after a period of time.…”

Section: Supporting Informationmentioning

confidence: 99%

“…Pain can be classified into two types, a nociceptive, acute skin pain, which correlates well with the severity of skin lesions, 3,4 and a chronic central sensitization, which some patients call pain, and is associated with their overall performance not only due to HS. 5,6 Although acute skin pain could become a well-established patient-reported outcome measure instrument, few studies have evaluated its impact in a reproducible, as objective as possible, manner. 4,5 The retrospective visual analogue scale of pain in daily, weekly or monthly intervals has been included in clinical studies 7 with the intrinsic disadvantage of exact symptom severity recalling by the patients.…”

Section: Supporting Informationmentioning

confidence: 99%

“…K. Tascilar, 1 O. Bayindir,2 A. Dogru,3 I. Tinazzi,4 G. Kimyon,5 C. Ozisler,6 A. Erden, 7 E. Dalkilic, 8 G.Y. Cetin, 9 S. YIlmaz, 10 D. Solmaz iD , 11 S. Bakirci iD , 12 A. Omma,13 T. Kasifoglu, 14 O. Kucuksahin, 15 M. Cinar, 16 L. Kilic, 7 M. Can, 17 E.F. Tarhan, 18 E. Bilgin iD , 7 E.D.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Pain Index: a new prospective hidradenitis suppurativa patient‐reported outcome measure instrument

Zouboulis

2021

Br J Dermatol

View full text Add to dashboard Cite

Quantitative Sensory Testing to Characterize Sensory Changes in Hidradenitis Suppurativa Skin Lesions

Alsouhibani,

Speck,

Cole

et al. 2023

JAMA Dermatol

View full text Add to dashboard Cite

ImportancePain is the most impactful symptom in patients with hidradenitis suppurativa (HS). Characterization of sensory profiles may improve understanding of pain mechanisms in HS and facilitate identification of effective pain management strategies.ObjectiveTo characterize somatosensory profiles in patients with HS at clinically affected and nonaffected sites compared with pain-free reference data.Design, Setting, and ParticipantsThis cross-sectional study was conducted at the Emory University Dermatology Clinic. It was hypothesized (1) that patients with HS would demonstrate hypersensitivity to pain in HS lesions and (2) that some patients would have sensory profiles consistent with complex pain mechanisms. Therefore, adults with dermatologist-diagnosed HS and at least 1 painful HS lesion at the time of testing were enrolled between September 10, 2020, and March 21, 2022. Patients with other diagnoses contributing to pain or neuropathy were excluded. Data analysis was conducted between March and April 2022.ExposureQuantitative sensory testing was performed on HS lesions and control skin according to a standardized protocol.Main Outcomes and MeasuresQuantitative sensory testing outcomes included innocuous thermal and mechanical sensitivity (cold, warmth, and light touch detection thresholds), noxious thermal and mechanical sensitivity (cold, heat, pinprick, and deep pressure pain thresholds and suprathreshold pinprick sensitivity), temporal summation of pinprick, paradoxical thermal sensations, and dynamic mechanical allodynia (pain upon light stroking of the skin). Sensitivity in HS lesions was compared with sensitivity in a control location (the hand) and in pain-free controls using t tests.ResultsThis study included 20 participants with a median age of 35.5 (IQR, 30.0-46.5) years, the majority of whom were women (15 [75%]). In terms of race and ethnicity, 2 participants (10%) self-identified as Asian, 11 (55%) as Black, 6 (30%) as White, and 1 (5%) as more than 1 race or ethnicity. Compared with site-specific reference values from healthy, pain-free control participants, HS lesions were insensitive to innocuous cold and warmth, noxious heat, and light touch (t = −5.69, −10.20, −3.84, and 4.46, respectively; all P &lt; .001). In contrast, HS lesions also demonstrated significant hypersensitivity to deep pressure pain (t = 8.36; P &lt; .001) and cutaneous pinprick (t = 2.07; P = .046). Hypersensitivity to deep pressure pain was also observed in the control site (t = 5.85; P &lt; .001). A subset of patients with HS displayed changes in pain processing that are often seen in neuropathic and nociplastic pain conditions, including hypersensitivity to repetitive pinprick (5 [26%]), paradoxical thermal sensations (3 [15%]), and pain upon light stroking of the skin (10 [50%]).Conclusions and RelevanceThe findings of this cross-sectional study suggest that HS involves local changes in the skin or its free nerve endings, possibly leading to peripheral neuropathy and alterations in the transduction of innocuous and noxious thermal and mechanical stimuli. For some patients, central nervous system changes in somatosensory processing may also occur, but confirmatory evidence is needed. Better understanding of neuropathic and nociplastic mechanisms in HS pain could lead to individually tailored treatments.

show abstract

Prevalence of Neuropathic Pain and Related Characteristics in Hidradenitis Suppurativa: A Cross-Sectional Study

Cited by 12 publications

References 43 publications

New treatments and new assessment instruments for Hidradenitis suppurativa

New treatments and new assessment instruments for Hidradenitis suppurativa

Pain Index: a new prospective hidradenitis suppurativa patient‐reported outcome measure instrument

Quantitative Sensory Testing to Characterize Sensory Changes in Hidradenitis Suppurativa Skin Lesions

Contact Info

Product

Resources

About