Prevalence of neonicotinoid insecticides in paired private-well tap water and human urine samples in a region of intense agriculture overlying vulnerable aquifers in eastern Iowa

Thompson, Darrin A.; Kolpin, Dana W.; Hladik, Michelle L.; Lehmler, Hans‐Joachim; Meppelink, Shannon M.; Poch, Matthew C.; Vargo, John D.; Soupene, Victor A.; Irfan, Nafis Md.; Robinson, Morgan; Kannan, Kurunthachalam; Freeman, Laura E. Beane; Hofmann, Jonathan N.; Cwiertny, David M.; Field, R. William

doi:10.1016/j.chemosphere.2023.137904

Cited by 15 publications

(7 citation statements)

References 58 publications

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“…A recent study reported a 100% detection frequency of this chemical in human urine (max. concentration: 1.1 µg·g −1 ) [ 55 ]. Similarly, 1,2-benzisothiazolinone, widely used as a preservative and antimicrobial, was found in 50% of the samples at levels up to 41.3 ng·mL −1 .…”

Section: Resultsmentioning

confidence: 99%

Comprehensive profiling and semi-quantification of exogenous chemicals in human urine using HRMS-based strategies

Gutiérrez-Martín,

Restrepo-Montes,

Golovko

et al. 2023

Anal Bioanal Chem

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Chemicals infiltrate our daily experiences through multiple exposure pathways. Human biomonitoring (HBM) is routinely used to comprehensively understand these chemical interactions. Historically, HBM depended on targeted screening methods limited to a relatively small set of chemicals with triple quadrupole instruments typically. However, recent advances in high-resolution mass spectrometry (HRMS) have facilitated the use of broad-scope target, suspect, and non-target strategies, enhancing chemical exposome characterization within acceptable detection limits. Despite these advancements, establishing robust and efficient sample treatment protocols is still essential for trustworthy broad-range chemical analysis. This study sought to validate a methodology leveraging HRMS-based strategies for accurate profiling of exogenous chemicals and related metabolites in urine samples. We evaluated five extraction protocols, each encompassing various chemical classes, such as pharmaceuticals, plastic additives, personal care products, and pesticides, in terms of their extraction recoveries, linearity, matrix effect, sensitivity, and reproducibility. The most effective protocol was extensively validated and subsequently applied to 10 real human urine samples using wide-scope target analysis encompassing over 2000 chemicals. We successfully identified and semi-quantified a total of 36 chemicals using an ionization efficiency-based model, affirming the methodology’s robust performance. Notably, our results dismissed the need for a deconjugation step, a typically labor-intensive and time-consuming process. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Comprehensive profiling and semi-quantification of exogenous chemicals in human urine using HRMS-based strategies

Gutiérrez-Martín,

Restrepo-Montes,

Golovko

et al. 2023

Anal Bioanal Chem

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“…Rational Use of Pesticides. Te proper choice of pesticides, dosage rates, dilutions, timing, frequency of application, treatment intervals, mode of application, precautions, and limitations are all part of the rational use of pesticides [135]. Pesticide residues in food products can be decreased through the prudent use of pesticides, and a pesticide may not always be necessary, especially when cultural or biological techniques work well [136].…”

Section: Management Of Pesticide Residues In Fruits and Vegetablesmentioning

confidence: 99%

Residue of Pesticides in Fruits, Vegetables, and Their Management in Ethiopia

Gelaye,

Negash

2024

Journal of Chemistry

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In Ethiopia, using pesticides to manage pests in the growing of fruits and vegetables is a standard practice. Various classes of pesticides have been approved to combat pests, but the majority of those in use now are outdated broad-spectrum insecticides with significant residual effects on crops of freshly eaten fruits and vegetables. This review reveals that Ethiopia’s assessment of the residual pesticide level in fruits and vegetables has been lacking. According to the reviewed literature, crops that are often treated with pesticides in many countries have significant residual pesticide levels. However, Ethiopia has not adequately reported on this issue. Furthermore, due to a lack of knowledge regarding the impact of pesticide residues on human health, Ethiopians frequently use pesticides improperly to control pests in fruits and vegetables. The majority of consumers eat their fruits and vegetables unprocessed, without washing or cooking them first. To reduce the risk of pesticide residues in fruits and vegetables for consumer safety and to battle the health effects of toxic chemicals in humans, monitoring pesticide residues and raising awareness about the adverse effects of pesticides on humans are urgently needed. Before they may be registered and sold, pesticide residues in fruits and vegetables as well as in the environment must also undergo proper testing and evaluation. New pesticide generations that have fewer side effects on fruits and vegetables must also be developed. By washing, peeling, canning, or boiling fruits and vegetables before consumption, the detrimental effects of pesticide residues on human health can be minimized.

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Section: Introductionmentioning

confidence: 99%

“…25 High detection frequencies (70%) of urinary metabolites of neonicotinoids were also reported among samples collected from rural Iowa, US. 26 However, it is difficult to estimate neonicotinoid exposure over time in urine samples, since the intraclass correlation coefficient values for each neonicotinoid are relatively low. 27 Several studies have shown the adverse effects of neonicotinoids in mammals through their harmful effects on the digestive, endocrine, hepatic, neurological, and reproductive systems.…”

Section: Introductionmentioning

confidence: 99%

Associations between neonicotinoids and liver function measures in US adults: National Health and Nutrition Examination Survey 2015–2016

Godbole,

Chen,

Vuong

2024

Environmental Epidemiology

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Background: Toxicological studies indicate that neonicotinoids may be associated with disruptions in liver function due to an increase in oxidative stress. There are scant epidemiological studies investigating the chronic hepatotoxic effects of neonicotinoids. Objective: To examine the association between detectable concentrations of parent neonicotinoids and neonicotinoid metabolites with liver function markers among US adults, and whether sex modifies this association. Methods: National Health and Nutrition Examination Survey 2015–2016 data were used to estimate associations between detectable neonicotinoids and serum alkaline phosphatase (ALP), alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transaminase (GGT), albumin, total bilirubin, total protein, and Hepatic Steatosis Index (HSI) using multiple linear regression. Results: Detectable levels of N-desmethyl-acetamiprid were associated with a decrease in GGT (β = −3.54 unit/l; 95% confidence interval [CI] = −6.48, −0.61) and detectable levels of 5-hydroxy-imidacloprid were associated with a decrease in HSI (β = −1.11; 95% CI = −2.14, −0.07). Sex modified the association between any parent neonicotinoid and ALP (P int = 0.064) and the association between clothianidin and ALP (P int = 0.019), with a pattern of positive associations in males and inverse associations in females, though stratified associations did not reach statistical significance. Sex also modified the association between 5-hydroxy-imidacloprid and total protein (P int = 0.062), with a significant positive association in females (β = 0.14 g/dl; 95% CI = 0.03, 0.25) and a null association in males. Conclusion: Detectable concentrations of neonicotinoid metabolites were inversely associated with GGT and HSI in US adults. Evidence suggests neonicotinoids may influence liver function differently depending on sex. Future research is recommended to replicate the findings as the study was limited in its cross-sectional nature and inability to examine continuous neonicotinoid concentrations with liver function.

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Prevalence of neonicotinoid insecticides in paired private-well tap water and human urine samples in a region of intense agriculture overlying vulnerable aquifers in eastern Iowa

Cited by 15 publications

References 58 publications

Comprehensive profiling and semi-quantification of exogenous chemicals in human urine using HRMS-based strategies

Comprehensive profiling and semi-quantification of exogenous chemicals in human urine using HRMS-based strategies

Residue of Pesticides in Fruits, Vegetables, and Their Management in Ethiopia

Associations between neonicotinoids and liver function measures in US adults: National Health and Nutrition Examination Survey 2015–2016

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