Prevalence of nasal carriage of methicillin-resistant Staphylococcus aureus in children with diabetes mellitus: Trends between 2005 and 2013

Karadağ‐Öncel, Eda; Gönç, Nazlı; Altay, Özlem; Cengiz, Ali Bülent; Özön, Alev; Pinar, Ahmet; Ceyhan, Mehmet; Alikaşifoğlu, Ayfer; Akyön, Yakut; Kandemir, Nurgün; Özsürekçi, Yasemin; Kara, Ateş

doi:10.1016/j.ajic.2015.04.206

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…The prevalence of MRSA (4.16%, 22/529) nasal colonization among the community-based diabetes population in this study was lower than those of type 2 diabetes patients in China (5.28%, 22/417) 18 , a diabetic outpatient population in Turkey (9.87%, 30/304) 21 and long-term hemodialysis type 2 diabetes patients in Saudi Arabia (18.97%, 11/58) 28 , but was higher than those of hospitalized diabetic patients in China (0.50%, 1/ 200) 20 , diabetes patients in Australia (1.21%, 8/660) 19 and type 1 diabetes pediatric outpatients in Turkey (in 2005, 0.99%, 1/101; in 2013, 0.75%, 1/134) 29 .…”

Section: Discussionsupporting

confidence: 92%

Prevalence and characteristics ofStaphylococcus aureusand methicillin‐resistantStaphylococcus aureusnasal colonization among a community‐based diabetes population in Foshan, China

Lin

Yang

et al. 2016

J of Diabetes Invest

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Aims/IntroductionEvidence suggests that diabetes might cause an increase in colonization of Staphylococcus aureus (S. aureus) and methicillin‐resistant S. aureus (MRSA) in community settings. We carried out a cross‐sectional study to determine the prevalence and influencing factors of S. aureus and MRSA nasal colonization among a community‐based diabetes population, and to identify the characteristics of the isolated strains.Materials and MethodsA total of 956 participants from 11 community settings were included in the study.ResultsOf the 529 diabetes participants, 46 were colonized with S. aureus and 22 were colonized with MRSA. Of the 427 non‐diabetes participants, 25 were colonized with S. aureus and 12 were colonized with MRSA. Men (odds ratio 0.45, 95% confidence interval 0.20–0.99, P = 0.047) were less likely to have S. aureus nasal colonization, and those with well‐controlled blood glucose (odds ratio 2.04, 95% confidence interval 1.01–4.13, P = 0.047) among the diabetes population were more likely to have S. aureus nasal colonization. The proportion of multidrug‐resistant S. aureus strains in the diabetes population (52.17%) was higher than that in the non‐diabetes population (28.00%; χ2 = 3.848, P = 0.050). The most common clonal complex type and Staphylococcal chromosome cassette mec type of MRSA in diabetes population was clonal complex 5 (40.91%) and type IV (27.27%), respectively. The proportion of Panton–Valentine leukocidin gene in MRSA strains was 17.65%. There was great sequence type diversity in MRSA strains.ConclusionsThe prevalence of MRSA in the community‐based diabetes population was moderate, and the high proportions of multidrug‐resistant S. aureus strains and diverse molecular characteristics in the diabetes population should be noticed.

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Section: Discussionsupporting

confidence: 92%

Prevalence and characteristics ofStaphylococcus aureusand methicillin‐resistantStaphylococcus aureusnasal colonization among a community‐based diabetes population in Foshan, China

Lin

Yang

et al. 2016

J of Diabetes Invest

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“…The colonization rate of 5.3% was in between those identified in the general adult and pediatric populations in Taiwan and is comparable with that of children with underlying conditions (5.4%) [40]. However, the rate is much higher than that reported in patients with type 1 diabetes in Turkey (0.7% to 0.9%) [42]. The difference might be related to the relatively low nasal MRSA colonization rate in healthy adults (0.37%) and children (0.07%) in Turkey [43,44].…”

Section: Discussionsupporting

confidence: 51%

“…Although the epidemiology of nasal MRSA colonization in children has been widely studied in different populations [40,41], the investigation of nasal MRSA colonization in patients with type 1 diabetes has been limited. In Turkey, Karadag-Oncel et al reported nasal MRSA colonization rates of 0.7% in 2005 and 0.9% in 2013 [42]. No studies have evaluated this in Asian countries.…”

Section: Discussionmentioning

confidence: 99%

Nasal Methicillin-Resistant Staphylococcus aureus Colonization in Patients with Type 1 Diabetes in Taiwan

et al. 2021

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Nasal methicillin-resistant Staphylococcus aureus (MRSA) colonies are an essential reservoir of infection, especially for patients with diabetes. However, data on MRSA colonization in patients with type 1 diabetes are limited. We investigated the epidemiology of MRSA colonization in patients with type 1 diabetes. This prospective cross-sectional study was conducted in a medical center (Chang Gung Memorial Hospital) in Taiwan from 1 July to 31 December 2020. Nasal sampling and MRSA detection were performed. The molecular characteristics of MRSA isolates were tested, and factors associated with MRSA colonization were analyzed. We included 245 patients with type 1 diabetes; nasal MRSA colonization was identified in 13 (5.3%) patients. All isolates belonged to community-associated MRSA genetic strains; the most frequent strain was clonal complex 45 (53.8%), followed by ST59 (30.8%) (a local community strain). MRSA colonization was positively associated with age ≤ 10 years, body mass index < 18 kg/m2, and diabetes duration < 10 years; moreover, it was negatively associated with serum low-density lipoprotein cholesterol ≥ 100 mg/dL. No independent factor was reported. The nasal MRSA colonization rate in type 1 diabetes is approximately 5% in Taiwan. Most of these colonizing strains are community strains, namely clonal complex 45 and ST59.

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The prevalence of methicillin-resistant Staphylococcus aureus among diabetic patients: a meta-analysis

et al. 2019

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Aims Diabetic patients have multiple risk factors for colonisation with methicillin-resistant Staphylococcus aureus (MRSA), a nosocomial pathogen associated with significant morbidity and mortality. This meta-analysis was conducted to estimate the prevalence of MRSA among diabetic patients. Methods The MEDLINE, Embase, BIOSIS, and Web of Science databases were searched for studies published up to May 2018 that reported primary data on the prevalence of MRSA in 10 or more diabetic patients. Two authors independently assessed study eligibility and extracted the data. The main outcomes were the pooled prevalence rates of MRSA colonisation and infection among diabetic populations. Results Eligible data sets were divided into three groups containing data about the prevalence of MRSA colonisation or in diabetic foot or other infections. From 23 data sets, the prevalence of MRSA colonisation among 11577 diabetics was 9.20% (95% CI, 6.26–12.63%). Comparison of data from 14 studies that examined diabetic and non-diabetic patients found that diabetics had a 4.75% greater colonisation rate ( P < 0.0001). From 41 data sets, the prevalence of MRSA in 10994 diabetic foot infection patients was 16.78% (95% CI, 13.21–20.68%). Among 2147 non-foot skin and soft-tissue infections, the MRSA prevalence rate was 18.03% (95% CI, 6.64–33.41). Conclusions The prevalence of MRSA colonisation among diabetic patients is often higher than among non-diabetics; this may make targeted screening attractive. In the UK, many diabetic patients may already be covered by the current screening policies. The prevalence and impact of MRSA among diabetic healthcare workers requires further research. The high prevalence of MRSA among diabetic foot infections may have implications for antimicrobial resistance, and should encourage strategies aimed at infection prevention or alternative therapies. Electronic supplementary material The online version of this article (10.1007/s00592-019-01301-0) contains supplementary material, which is available to authorized users.

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Prevalence of nasal carriage of methicillin-resistant Staphylococcus aureus in children with diabetes mellitus: Trends between 2005 and 2013

Cited by 4 publications

References 11 publications

Prevalence and characteristics ofStaphylococcus aureusand methicillin‐resistantStaphylococcus aureusnasal colonization among a community‐based diabetes population in Foshan, China

Prevalence and characteristics ofStaphylococcus aureusand methicillin‐resistantStaphylococcus aureusnasal colonization among a community‐based diabetes population in Foshan, China

Nasal Methicillin-Resistant Staphylococcus aureus Colonization in Patients with Type 1 Diabetes in Taiwan

The prevalence of methicillin-resistant Staphylococcus aureus among diabetic patients: a meta-analysis

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