Prevalence of mycotoxigenic fungi and assessment of aflatoxin contamination: a multiple case study along the integrated corn‐based poultry feed supply chain in Malaysia

Nasaruddin, Norafidah; Selamat, Jinap; Samsudin, Nik Iskandar Putra; Kamarulzaman, Nitty Hirawaty; Sanny, Maimunah

doi:10.1002/jsfa.10795

Cited by 10 publications

(9 citation statements)

References 51 publications

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“…In other cases, the extract after SLE may not be clear enough, necessitating a second cleanup step. Several authors have used immunoaffinity columns (IAC) before LC-FLD [70][71][72][73][74][75][76][77][78], LC-MS/MS [54,79,80], or LC coupled with an ultraviolet detector [73,77]. IAC-based clean-up is highly specific since these columns are composed of monoclonal antibodies against the mycotoxins of interest.…”

Section: Methodsmentioning

confidence: 99%

“…Regarding the techniques for detecting and quantifying mycotoxins in animal feed, most authors used LC (on reversed-phase columns) coupled with mass spectrometry [54,60,61,64,[66][67][68][79][80][81][83][84][85][86][87][88], employing electrospray ionization and triple quadrupoles (QqQs) or quadrupole ion traps (QTraps) as mass analyzers. In addition, LC coupled with FLD has been widely used [53,63,68,[70][71][72][73][74][75][76][77][78]82], and, in some cases (for DON quantification), LC has been coupled with an ultraviolet detector [73,77].…”

Section: Methodsmentioning

confidence: 99%

“…LC-FLD is less expensive and easier to use than LC-MS/MS, having good specificity and sensitivity. However, multidetection is more limited than in the case of mass spectrometer (MS) detection, and some mycotoxins require derivatization before quantification [53,70,71,[74][75][76]. The development of new methodologies that facilitate the rapid, easy, and inexpensive analysis of mycotoxins in feed is essential for both research and feed control in small laboratories.…”

Section: Methodsmentioning

confidence: 99%

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Monitoring Mycotoxin Exposure in Food-Producing Animals (Cattle, Pig, Poultry, and Sheep)

Muñoz-Solano,

Lizarraga Pérez,

González-Peñas

2024

Toxins

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Food-producing animals are exposed to mycotoxins through ingestion, inhalation, or dermal contact with contaminated materials. This exposure can lead to serious consequences for animal health, affects the cost and quality of livestock production, and can even impact human health through foods of animal origin. Therefore, controlling mycotoxin exposure in animals is of utmost importance. A systematic literature search was conducted in this study to retrieve the results of monitoring exposure to mycotoxins in food-producing animals over the last five years (2019–2023), considering both external exposure (analysis of feed) and internal exposure (analysis of biomarkers in biological matrices). The most commonly used analytical technique for both approaches is LC-MS/MS due to its capability for multidetection. Several mycotoxins, especially those that are regulated (ochratoxin A, zearalenone, deoxynivalenol, aflatoxins, fumonisins, T-2, and HT-2), along with some emerging mycotoxins (sterigmatocystin, nivalenol, beauvericin, enniantins among others), were studied in 13,818 feed samples worldwide and were typically detected at low levels, although they occasionally exceeded regulatory levels. The occurrence of multiple exposure is widespread. Regarding animal biomonitoring, the primary objective of the studies retrieved was to study mycotoxin metabolism after toxin administration. Some compounds have been suggested as biomarkers of exposure in the plasma, urine, and feces of animal species such as pigs and poultry. However, further research is required, including many other mycotoxins and animal species, such as cattle and sheep.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Monitoring Mycotoxin Exposure in Food-Producing Animals (Cattle, Pig, Poultry, and Sheep)

Muñoz-Solano,

Lizarraga Pérez,

González-Peñas

2024

Toxins

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“…According to the European Union (EU) and Food and Agriculture Organization (FAO) legislation, the maximum tolerable levels for total AF in poultry feeds are 20 µg/kg (FAO 2004;Nasaruddin et al 2021). In Nigeria, the European Commission and Codex Alimentarius Standards mycotoxin regulations were adopted and are used primarily for export commodities.…”

Section: Af Occurrence Of Samplesmentioning

confidence: 99%

Assessment of aflatoxin and heavy metals levels in maize and poultry feeds from Delta State, Nigeria

Ifie

Igwebuike

Imasuen

et al. 2022

Int. J. Environ. Sci. Technol.

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The aim of this study was to determine the concentration of total aflatoxin and heavy metals (lead cadmium, chromium and copper) in poultry feed and ingredients from two regions (north and central) in Delta State, Nigeria. A total of 120 samples collected (comprising of maize, soybean meal, layers mash and broiler finisher) directly from poultry farms, feed mills and poultry feed dealers were analysed for moisture content, total aflatoxin and heavy metals (lead, cadmium, chromium and copper) concentrations. Moisture content was analysed using standard Association of Official Agricultural Chemists method, while total aflatoxin and heavy metals concentrations were determined by enzyme-linked immunosorbent assay and atomic absorption spectrometry, respectively. Total aflatoxins concentrations ranged from 12.0 to 20 µg/kg and 21 to 31 µg/kg in samples from north and central region, respectively. Apart from maize, aflatoxin content in other samples from the north was marginally lower (18–20 µg/kg) than permitted levels. On the other hand, aflatoxin levels in samples from the central were all above tolerable limits. Copper content in samples was less than permissible limit, while 44.4, 29.1 and 21% of samples had concentrations of lead, cadmium and chromium, respectively, above permissible limit. The presence of aflatoxin and lead in poultry feeds above permissible limits of 20 µg/kg and 5 mg/kg, respectively, may pose a risk for animal productivity and human health.

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“…One of the most common types of mycotoxins, aflatoxins are created through agricultural practices such growing, harvesting, storing, and processing. There is evidence that aflatoxin M1 can be passed on through breast milk [1][2][3][4][5][6][7][8]..…”

mentioning

confidence: 99%

Limits of Detection Determination of Aflatoxin B1 using the Optical Waveguide Lightmode Spectroscopy via the Four-Parameter Logistic Model

Uba

Yakasai

Abubakar

2022

Bioremed Sci Technol Res

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Mycotoxins are harmful secondary metabolites generated by a variety of fungi, and they may be found in a vast array of food and feed commodities and processed meats from animals fed infected meal. Numerous mycotoxins are extremely resistant and survive food processing, entering the food chain and posing a concern to human health. The "optical waveguide lightmode spectroscopy" (OWLS) method was used to detect aflatoxin B1 in plant sample matrices. The calibration curve for the detection of aflatoxin B1 utilizing "optical waveguide lightmode spectroscopy" (OWLS) displayed a sigmoidal shape; hence, the 5-PL or 4-PL model should be used to fit the data rather than a linear model. Using error function analysis with functions such as AICc, HQC, BIC, RMSE, adjR2, Bias Factor, and Accuracy Factor, the 5-PL and 4-Pl models are distinguished inconsistently. The overlapping confidence intervals of the LogEC50 values suggested that the two techniques did not differ much, and the 4-PL model was selected due to its smaller number of parameters. The Limits of Detection for aflatoxin B1 value based on the 4-PL equation was 8.787 ng/mL with the 95% confidence interval from 5.728 to 13.100. In this study, the use of the 4-PL model was successful and was able to represent the entire date curve, not only the linear section. The linear component is crucial as a handy and swift approach for assessing the sensitivity of a developed biosensor technology and is often a more beneficial method for field applications when a quick and straightforward evaluation is required.

show abstract

Prevalence of mycotoxigenic fungi and assessment of aflatoxin contamination: a multiple case study along the integrated corn‐based poultry feed supply chain in Malaysia

Cited by 10 publications

References 51 publications

Monitoring Mycotoxin Exposure in Food-Producing Animals (Cattle, Pig, Poultry, and Sheep)

Monitoring Mycotoxin Exposure in Food-Producing Animals (Cattle, Pig, Poultry, and Sheep)

Assessment of aflatoxin and heavy metals levels in maize and poultry feeds from Delta State, Nigeria

Limits of Detection Determination of Aflatoxin B1 using the Optical Waveguide Lightmode Spectroscopy via the Four-Parameter Logistic Model

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