Prevalence of Musculoskeletal Disorders in Patients with Coronary Artery Disease

Баздырев, Е. Д.; Terentyeva, N. A.; Кривошапова, К. Е.; Масенко, В. Л.; Wegner, Eva A; Kokov, А. N.; Помешкина, С. А.; Барбараш, О. Л.

doi:10.20996/1819-6446-2021-06-03

Cited by 3 publications

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References 31 publications

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“…In the scientific literature, the prevalence of sarcopenia, osteopenia, and osteoporosis in cardiac patients is widely discussed, while there are very few works devoted to the combination of these conditions. Bazdyrev and colleagues [ 63 ] investigated the prevalence of musculoskeletal disorders in 387 patients aged 50–82 years with stable coronary artery disease (CAD). The most common type of musculoskeletal disorder was sarcopenia with 13.4%; osteopenia/osteoporosis was detected in 7.2%, and; OS in 6.5%.…”

Section: Clinical Studies On Osteosarcopenia and Associated Risk Factorsmentioning

confidence: 99%

Osteosarcopenia: A Narrative Review on Clinical Studies

Polito¹,

Barnaba²,

Ciarapica³

et al. 2022

IJMS

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Osteosarcopenia (OS) is defined by the concurrent presence of osteopenia/osteoporosis and sarcopenia. The pathogenesis and etiology of OS involve genetic, biochemical, mechanical, and lifestyle factors. Moreover, an inadequate nutritional status, such as low intake of protein, vitamin D, and calcium, and a reduction in physical activity are key risk factors for OS. This review aims to increase knowledge about diagnosis, incidence, etiology, and treatment of OS through clinical studies that treat OS as a single disease. Clinical studies show the relationship between OS and the risk of frailty, falls, and fractures and some association with Non-communicable diseases (NCDs) pathologies such as diabetes, obesity, and cardiovascular disease. In some cases, the importance of deepening the related mechanisms is emphasized. Physical exercise with adequate nutrition and nutritional supplementations such as proteins, Vitamin D, or calcium, represent a significant strategy for breaking OS. In addition, pharmacological interventions may confer benefits on muscle and bone health. Both non-pharmacological and pharmacological interventions require additional randomized controlled trials (RCT) in humans to deepen the synergistic effect of exercise, nutritional interventions, and drug compounds in osteosarcopenia.

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Section: Clinical Studies On Osteosarcopenia and Associated Risk Factorsmentioning

confidence: 99%

Osteosarcopenia: A Narrative Review on Clinical Studies

Polito¹,

Barnaba²,

Ciarapica³

et al. 2022

IJMS

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“…для женщин в постменопаузе, по Т-критерию, полученному при двухэнергетической рентгеновской абсорбциометрии -у мужчин старше 50 лет [18]. При сочетании у одного пациента саркопении с остеопеническим синдромом диагностировали остеосаркопению [19].…”

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Respiratory Muscle Strength in Patients with Coronary Heart Disease and Different Musculoskeletal Disorders

Баздырев

Terentyeva

Galimova

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To measure respiratory muscle strength (RMS) in patients with coronary heart disease (CHD) and different musculoskeletal disorders (MSD).Material and methods. Patients were divided in four groups according to the MSD. Group I included 52 (13.4%) patients with sarcopenia, group II included 28 (7.2%) patients with osteopenia, group III included 25 (6.5%) patients with osteosarcopenia, group IV included 282 (72.9%) patients without MSD. All patients underwent the assessment of maximal expiratory (МЕР) and maximal inspiratory mouth pressures (MIP).Results. The mean RMS values were lower than the normative values, and the strength of the expiratory muscles was 1.25 times lower compared to the inspiratory muscles. Both of these parameters were within the normal range in 191 (49.3%) patients, and lower values were noted in 196 (50.7%). An isolated decrease in MIP was observed in 24.8% of patients, an isolated decrease in МЕР in 6.5%, a combined decrease in MIP and МЕР in 19.4% of patients. Comparative analysis of МЕР and MIP (depending on the MSD) did not demonstrate statistically significant differences. Lower МЕР (76.9%) and MIP (75%) values were noted mainly in the group of patients with sarcopenia. A similar pattern was notes in patients with osteosarcopenia and in patients without MSD. Normative values of RMS were observed in patients with osteopenia. Correlation analysis revealed a unidirectional relationship between RMS and the parameters of muscle function (hand grip strength, muscle area and musculoskeletal index) and a multidirectional relationship between МЕР and BMI (r -0.743, p=0.013), MIP and patient age (r -0.624, p=0.021).Conclusion. Respiratory muscle weakness was diagnosed in half of the patients with coronary heart disease. There were no statistically significant differences in RMS between patients with MSD and isolated CHD, despite lower values in the group with MSD. Correlation analysis revealed an association between RMS and muscle function.

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Risk factors for unfavorable prognosis in patients with coronary artery disease and age-related disorders undergoing coronary artery bypass grafting

Terentyeva

Galimova

Баздырев

et al. 2023

Kompleks. probl. serdečno-sosud. zabol.

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Highlights. Patients with coronary artery disease and age-related disorders (sarcopenia, osteopenic syndrome, osteosarcopenia) who underwent elective on-pump coronary artery bypass grafting are at higher risk of developing cardiovascular complications, non-infectious complications, and death.Musculoskeletal disorders (sarcopenia, osteopenic syndrome, osteosarcopenia) in combination with traditional predictors (age, diabetes mellitus, prior myocardial infarction and stroke, cancer) are risk factors for unfavorable prognosis of postoperative period of coronary artery bypass grafting. Aim. To assess risk factors for unfavorable prognosis in patients with coronary artery disease (CAD) undergoing elective on-pump coronary artery bypass grafting, taking into account age-related disorders (sarcopenia, osteopenic syndrome, osteosarcopenia).Methods. This single-center study included 387 CAD patients admitted for elective coronary artery bypass grafting. Taking into account the diagnosed age-related disorders, four groups of patients were formed. The first group consisted of 52 (13.4%) patients with sarcopenia, the second group was comprised of 28 (7.2%) patients with osteopenia (osteopenia/osteoporosis), the third group included 25 (6.5%) patients with osteosarcopenia, and the fourth group consisted of 282 (72.9%) participants with coronary artery disease and without musculoskeletal disorders (MSD). Risk factors for a composite endpoint (myocardial infarction, stroke, paroxysmal atrial fibrillation, cardiac rhythm disturbances) and death, and noninfectious complications (resternotomy for bleeding, pneumothorax aspiration and thoracentesis) were assessed.Results. The composite endpoint occurred more frequently in patients with osteopenia (group I – 9.6%, group II – 32.1%, group III – 12%, group IV – 12.8%; p = 0.029), and non-infectious complications occurred more frequently in patients with sarcopenia and osteosarcopenia (group I – 17.3%, group II – 7.1%, group III – 12%, group IV – 5.3%; p = 0.002). MSD were associated with the risk of composite endpoint (odds ratio (OR) 1.73, p = 0.035), and osteopenia increased it three-fold (OR 3.01, p = 0.046). Moreover, MSD were associated with higher risk of non-infectious complications (OR 1.71, p = 0.026), especially in patients with sarcopenia (OR 2.02, p = 0.034). The assessment of risk factors for unfavorable prognosis highlighted the presence of osteopenic syndrome (100 CU), prior stroke (88 CU) and myocardial infarction (85 CU). The risk of non-infectious complications was associated with prior ischemic events (ranking level for myocardial infarction – 100 CU, stroke – 75 CU), and MSD (89 CU) and its types (osteosarcopenia – 77 CU, osteopenia – 69 CU, sarcopenia – 52 CU).Conclusion. Age-related disorders in combination with MSD increase the risk of a composite endpoint and non-infectious complications by one to three times.

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Prevalence of Musculoskeletal Disorders in Patients with Coronary Artery Disease

Cited by 3 publications

References 31 publications

Osteosarcopenia: A Narrative Review on Clinical Studies

Osteosarcopenia: A Narrative Review on Clinical Studies

Respiratory Muscle Strength in Patients with Coronary Heart Disease and Different Musculoskeletal Disorders

Risk factors for unfavorable prognosis in patients with coronary artery disease and age-related disorders undergoing coronary artery bypass grafting

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