Prevalence of multiple sclerosis in Brazil: A systematic review

Pereira, Ana Beatriz Calmon Nogueira da Gama; Lacativa, Maria Clinete Sampaio; Pereira, Fernanda Ferreira Chaves da Costa; Alvarenga, Regina Maria Papais

doi:10.1016/j.msard.2015.08.004

Cited by 42 publications

(36 citation statements)

References 25 publications

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“…3 LATAM presents different population genetics and environmental aspects around the region, with European and African immigrants resulted in a concentration of the Caucasian population in the southern regions of the continent whereas in the northern region, the population is predominately Mestizo. 6 In terms of epidemiological observations in the region, 3,7 information regarding incidence, prevalence and other aspects were described and allowed us to understand and compare the disease in LATAM with other regions of the world; however, novel data have appeared over the last few years that make the updating of the information about the frequency of the disease in our region relevant in order to better understand the distribution of the disease.…”

Section: Introductionmentioning

confidence: 99%

Multiple sclerosis epidemiology in Latin America: An updated survey

Cristiano¹,

Rojas

2017

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Novel epidemiological data have appeared in recent years in Latin America (LATAM). The objective of this study was to perform an updated systematic review of the epidemiology of the disease reported in LATAM.MethodsWe conducted a systematic review of published epidemiological articles from January 1995 to December 2016.ResultsIncidence data were found in four studies and ranged from 0.3 to 3 annual cases per 100,000 person-years. Prevalence was reported in 13 studies and ranged from 0.83 to 38.2 cases per 100,000 inhabitants. Two studies showed an increase in prevalence and incidence in the last five years in specific regions.ConclusionThe study provides updated information on epidemiological features of MS in the region. The frequency reported is lower compared with some European and North American countries; however, due to recent observations, studies including follow-up assessment of prevalence and incidence should be conducted in the region.

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Section: Introductionmentioning

confidence: 99%

Multiple sclerosis epidemiology in Latin America: An updated survey

Cristiano¹,

Rojas

2017

Multiple Sclerosis Journal - Experimental, Translational and Cl

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“…This sample was representative of a large population of people with MS, as 84% were women, and clinical and demographic data resembled other Brazilian cohorts 16 . It is important to indicate that there was no difference between genders regarding employment status, demographic and clinical data.…”

Section: Discussionmentioning

confidence: 90%

“…Therefore, it is possible that keeping people with MS in the labor market will help decrease these indirect costs and even improve their autonomy and well-being. Although the estimated prevalence of MS in Brazil is 20-30/100,000 15,16 , and there are many studies reporting clinical, radiological and immunological data regarding MS in Brazil, there is no objective information about the employment status of these patients.…”

Section: Introductionmentioning

confidence: 99%

Employment status of people diagnosed with multiple sclerosis in Brazil

Estrutti

Cardoso²,

Novais

et al. 2019

Arq. Neuro-Psiquiatr.

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Objective: To describe the employment status of Brazilians with multiple sclerosis (MS). Methods: Analysis of a cross-sectional online survey including questions on demographic and occupational status at the time of diagnosis and survey completion, and time from the first symptom to diagnosis. Results: Of those who answered the survey, 804 Brazilians with MS were included. Median age of onset and current age were 28.3 and 36.2 years; median time to diagnosis and disease duration were 2.7 and 7.9 years; 67% held a university degree and 29% finished high school; 94% had a paid occupation contributing to the family income at least once in their lives, 77% were employed at the time of diagnosis but only 59% were employed at the time of survey. Longer disease duration, longer time to diagnosis and younger age at the first symptom, were identified as factors correlated with being unemployed. Conclusions: The rate of unemployment doubled after the first symptoms of MS, and only 59% of highly-educated people with MS in their productive years were employed. The longer time to diagnosis may imply treatment delay, and strategies focusing on early diagnosis and adequate treatment may favor employment retention and reduce disability related costs, such as social benefits and pension fund use.

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“…The reasons for the variability in prevalence observed in Brazil might be related to (i) under diagnosis in poor rural areas, (ii) rates that are not adjusted for age or sex for example, (iii) wrong diagnosis and (iv) scarce skilled labor. Nevertheless, we think that a major source of heterogeneity is related to variations in latitude, climate and ethnicity in the wide territory of Brazil [37] .…”

Section: Discussionmentioning

confidence: 95%

Prevalence of Multiple Sclerosis in the City of Volta Redonda - Rio De Janeiro, Brazil Using the Capture-Recapture Method

Calmon

Pereira

Marin³

et al. 2016

Neuroepidemiology

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Background: Multiple sclerosis (MS) prevalence in Latin America was estimated in some regions and it was found to range from 0.75 to 30/100,000. The reasons for variation in rates of prevalence around the world still are not clear, but there are environmental and genetic explanations to this phenomenon. This study aimed at estimating the MS prevalence in Volta Redonda, Brazil. Method: Three sources of cases ascertainment were used and the method of capture-recapture was applied for assessing the corrected prevalence in the city of Volta Redonda in November 2012. The capture-recapture method uses data from incomplete lists and allows calculating the number of unregistered cases. Data were analyzed using a log-linear model. Results: A total of 40 MS cases was found by withdrawing overlaps of sources and it was estimated that a total number of 40 cases (95% CI 13.5-118.8) were not detected by the sources. The corrected prevalence of MS was, then, 30.7/100,000. Conclusion: Our study was the first in Brazil to use the capture-recapture method to assess the prevalence of MS, demonstrating the highest prevalence rate so far. It is necessary to perform other similar studies and in other regions of the country using the same method for a better evaluation of the true prevalence of MS our country.

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Prevalence of multiple sclerosis in Brazil: A systematic review

Cited by 42 publications

References 25 publications

Multiple sclerosis epidemiology in Latin America: An updated survey

Multiple sclerosis epidemiology in Latin America: An updated survey

Employment status of people diagnosed with multiple sclerosis in Brazil

Prevalence of Multiple Sclerosis in the City of Volta Redonda - Rio De Janeiro, Brazil Using the Capture-Recapture Method

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