Prevalence of Multidrug Resistant Tuberculosis among TB Patients in Malaysia

Abstract

Background: Currently multidrug-resistant tuberculosis (MDR-TB) poses a signi cant public health concern in Malaysia.Objective: This study is aimed to evaluate the prevalence of MDR-TB in Malaysian tuberculosis patients. Method. A retrospective analysis was performed, and data was obtained from the Malaysian National TB Information System (TBIS) between 2009 and 2019. A record of 989 MDR-TB cases were identi ed and associated risk characteristics such as marital status, gender, ethnicity, employment status, alcohol consumption, diabetic status and smoking status were determined. The statistical analysis was performed using the SPSS software version 20.Results: Overall, the occurrence of MDR-TB among patients with TB infections in Malaysia was 0.34% based on data collected from TBIS. The ndings revealed major variations in the incidence of MDR-TB between male and female patients (0.44%, 0.20%, p < 0.001), single and married patients (1.63% vs 0.24%, p < 0.001), ethnicity (p < 0.001), working and non-working patients (0.48% vs 0.32%, p < 0.001), alcoholic and non-alcoholic patients (0.44% vs 0.32%, p < 0.001), diabetic patients and non-diabetic patients (0.39% vs 0.27%, p < 0.001), followed by smoking and non-smoking patients (0.13% vs 0.27%, p < 0.001). Conclusion:This study provides a substantial assessment of MDR-TB prevalence and associated risk factors that could be useful for the implementation of new strategies in Malaysia's national TB policy.

Life Threatening Stridor Due to Primary Laryngeal Tuberculosis

“…10% of them meet the criteria for extensively drug-resistant with additional resistance to any fluoroquinolone, and to at least one injectable second-line drug (capreomycin, kanamycin or amikacin) [25] [26]. Malaysian National TB Information System (TBIS) between 2009 and 2019 reported that the incidence of MDR-TB among patients with TB infections in Malaysia was 0.34% [27]. Therefore, public education on prevention, early diagnosis, and treatment with good drug compliance is essential to avoid these disastrous complications and mortality.…”