Prevalence of Multidrug Resistance among<i>Salmonella enterica</i>Serovar Typhimurium Isolated from Pig Faeces in Ashanti Region, Ghana

Sekyere, John Osei; Adu, Francis

doi:10.1155/2015/898790

Cited by 12 publications

(16 citation statements)

References 8 publications

(6 reference statements)

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“…This finding shows similar pattern of high resistant Salmonella spp in previous study in China, where the multidrug resistant (MDR) Salmonella spp reported to be 80% in food animals when tested against 17 commonly used antibiotics for clinical applications [33]. Previously, report from Ghana also reported high prevalence of Salmonella spp (66.7%) which where the MDR of the isolates were reported to be 52.8% [34]. Across the world, prevalence of Salmonella spp were reported in varying degree with very low prevalence in Europe (2%) than other continents which is in contrast with the current study [35].…”

Section: Discussionsupporting

confidence: 86%

Detection of Multidrug Resistant Gram Negative Bacteria in Healthy Cattle from Maiduguri Metropolitan, Nigeria

Mustapha

Isa

Ngoshe

et al. 2020

JAMB

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Aim: Prevalence of multidrug resistant bacteria on apparently health animals has turned antibiotic resistance to multifaceted process and threatens global food security and public health. The aim of the present study was to investigate the resistance profile of isolates from apparently healthy cattle in Maiduguri, Nigeria. Methodology: A total of 120 nasal swab samples were collected from cattle. Colony identification was according to the guidelines of Bergey’s Manual of Determinative Bacteriology. The susceptibility pattern of the isolates was conducted on the identified isolates according to the Modified Kirby-Baur disc diffusion method on Muller-Hilton agar and interpreted according to the procedures of Clinical Laboratory Standards Institute (CLSI, 2018) guidelines. Multiple Antibiotic Resistance Index (MARI) was calculated using the formula, MARI=a/b where “a” is the number of antibiotic resisted and “b” is the total number of antibiotic used in the study. Results: Of the total samples (120) from cattle 96 (80%) detected the following isolates; E. coli was the most commonly recovered isolates (33, 34.4%), followed by Klebsiella spp (28, 29.2%), Salmonella spp (21, 21.9%) and Pseudomonas aeruginosa (14, 14.5%). In this study, all the recovered isolates were found to be multidrug resistant gram negative bacteria, with highest resistance was shown by Salmonella spp. The high MARI observed in all the isolates in this study ranging from 0.7 to 0.9. MARI value of 0.2 > is suggests multiple antibiotic resistant bacteria and indicate presence of highly resistant bacteria. Conclusion: The study indicates highly resistant bacteria are carried by healthy food animals. Thus, there is need for continued monitoring of antibiotics use in animal husbandry to prevent further spread of resistance in Maiduguri, Nigeria.

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Section: Discussionsupporting

confidence: 86%

Detection of Multidrug Resistant Gram Negative Bacteria in Healthy Cattle from Maiduguri Metropolitan, Nigeria

Mustapha

Isa

Ngoshe

et al. 2020

JAMB

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“…In China, it is estimated that 97 000 metric tons of the approximately 210 000 metric tons of antibiotics produced yearly are used in animal husbandry. Thus, a rise in the number of resistant bacteria in the animal gut has been observed (Zhao et al ., ), compounded by the fact that more than half of administered antibiotics are not absorbed in the animal gut and are, therefore, shed in the faeces, exposing the environment to subtherapeutic levels of antibiotics and contributing further to AMR (Osei Sekyere and Adu, ; Zhao et al ., ).…”

Section: Amr In Veterinary and Agricultural Sourcesmentioning

confidence: 99%

Understanding antimicrobial discovery and resistance from a metagenomic and metatranscriptomic perspective: advances and applications

Asante

Sekyere

2019

Environ Microbiol Rep

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Summary Our inability to cultivate most microorganisms, specifically bacteria, in the laboratory has for many years restricted our view and understanding of the bacterial meta‐resistome in all living and nonliving environments. As a result, reservoirs, sources and distribution of antibiotic resistance genes (ARGS) and antibiotic‐producers, as well as the effects of human activity and antibiotics on the selection and dissemination of ARGs were not well comprehended. With the advances made in the fields of metagenomics and metatranscriptomics, many of the hitherto little‐understood concepts are becoming clearer. Further, the discovery of antibiotics such as lugdinin and lactocillin from the human microbiota, buttressed the importance of these new fields. Metagenomics and metatranscriptomics are becoming important clinical diagnostic tools for screening and detecting pathogens and ARGs, assessing the effects of antibiotics, other xenobiotics and human activity on the environment, characterizing the microbiome and the environmental resistome with lesser turnaround time and decreasing cost, as well as discovering antibiotic‐producers. However, challenges with accurate binning, skewed ARGs databases, detection of less abundant and allelic variants of ARGs and efficient mobilome characterization remain. Ongoing efforts in long‐read, phased‐ and single‐cell sequencing, strain‐resolved binning, chromosomal‐conformation capture, DNA‐methylation binning and deep‐learning bioinformatic approaches offer promising prospects in reconstructing complete strain‐level genomes and mobilomes from metagenomes.

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“…Nonetheless, most of the reports on antibiotic use in food-animal production have been limited to the types of antibiotics employed, resistance of organisms isolated from these farms [24][25][26][27][28] and quantities of antibiotics used [25,26].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Practices and Factors Influencing the Use of Antibiotics in Selected Poultry Farms in Ghana

VE¹,

Agyare²

2016

J Antimicro

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Many of the antibiotics employed in animal production also serve as essential medicines for use in humans. However, only a handful of studies address antibiotic use in animal husbandry in Ghana. The aim of this study was to investigate the use of essential antibiotics in poultry production in Ghana and to assess factors influencing farmers' choice of antibiotics for use on their farms. A cross-sectional survey using questionnaires and semistructured interviews was conducted among 400 poultry farms in the Ashanti, Brong-Ahafo and Greater Accra regions of Ghana. Data was analysed using IBM SPSS and Microsoft Excel. Multivariate analyses were used to evaluate correlations between farm variables and the dependency of antibiotic use on internal and external farm characteristics. Farmers reported the use of 35 different antimicrobial agents for management of conditions such as Newcastle, fowl pox, coccidiosis, and coryza. From these agents, 20 essential antibiotics belonging to 10 antibiotic classes were extracted. Frequently employed antibiotics were tetracyclines (24.17%), aminoglycosides (17.87%), penicillins (16.51%) and fluoroquinolones (10.55%). Only 63% of the farms completed recommended antibiotic course durations, 58% reported following recommended withdrawal periods and 88% sought veterinary advice before administration of antibiotics. Farmers had easy access to antibiotics and antibiotic-related information from veterinary offices, vet-chemical shops and mobile salesmen. Correlation analysis showed farm activities such as frequency of change of bedding material, disinfectant use and seeking expert advice correlated significantly with size and age. The use of antibiotic-containing agents was observed to be dependent on internal factors such as size, presence of other livestock on the farm and infections. External factors such as easy access to antibiotics also influenced farmers' use of antibiotics. These findings call for stricter regulations on access to and use of antibiotics on poultry farms in Ghana.

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Prevalence of Multidrug Resistance amongSalmonella entericaSerovar Typhimurium Isolated from Pig Faeces in Ashanti Region, Ghana

Cited by 12 publications

References 8 publications

Detection of Multidrug Resistant Gram Negative Bacteria in Healthy Cattle from Maiduguri Metropolitan, Nigeria

Detection of Multidrug Resistant Gram Negative Bacteria in Healthy Cattle from Maiduguri Metropolitan, Nigeria

Understanding antimicrobial discovery and resistance from a metagenomic and metatranscriptomic perspective: advances and applications

Antibiotic Practices and Factors Influencing the Use of Antibiotics in Selected Poultry Farms in Ghana

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