Prevalence of movement disorders in adolescent patients with schizophrenia and in relationship to predominantly atypical antipsychotic treatment

Gebhardt, Stefan; Härtling, Fabian; Hanke, Markus S.; Mittendorf, Markus; Theisen, Frank; Wolf‐Ostermann, Karin; Grant, Phillip; Martı́n, Miguel Ángel; Fleischhaker, Christian; Schulz, Eberhard; Remschmidt, Helmut

doi:10.1007/s00787-006-0544-5

Cited by 34 publications

(26 citation statements)

References 84 publications

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“…However, the subscale scores strongly correlated with measures of hyperactivity or externalizing behaviors, like the SNAP and CBCL-ext. The BARS reportedly performs well for akathisia assessment in youth (Zalsman et al, 2011); however, more typically in the context of studies assessing antipsychotic mediation effects (e.g., (Gebhardt et al, 2006). Zalsman et al suggested that the BARS needs to distinguish restlessness associated with ADHD, which is intentional, goal-directed and not associated with subjective distress, from akathisia (Zalsman et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Psychometric properties of the Treatment-Emergent Activation and Suicidality Assessment Profile (TEASAP) in youth with OCD

Bussing

Murphy

Storch

et al. 2013

Psychiatry Research

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This study evaluated the psychometric properties of the treatment-emergent activation and suicidality assessment profile (TEASAP) in a clinical sample of 56 youth ages 7 to 17 with obsessive compulsive disorder (OCD) who participated in a double-blind randomized controlled trial. The 38-item TEASAP demonstrated good internal consistency for its total score (α = 0.93) and adequate to good performance for its five subscale scores (α = 0.65 to 0.92). One week test-retest stability (N = 18) was adequate (Intraclass correlation coefficient [ICC] = 0.68 to 0.80) except for Self-Injury (ICC = 0.46). Construct validity was supported by total and subscale TEASAP score relationships with related constructs, including irritability, hyperactivity, externalizing behaviors, manic symptoms, and suicidal ideation, and the absence of relationships with unrelated constructs. Predictive validity was established for the Disinhibition subscale through significant associations with subsequent activation events. Furthermore, TEASAP sensitivity to change in activation scores over time was supported by longitudinal associations of TEASAP scores with clinician ratings of activation over the course of treatment. Findings indicate that the TEASAP has acceptable psychometric properties in a clinical sample of youth with OCD and merits further study in larger samples for additional refinement of its measurement approaches.

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Section: Discussionmentioning

confidence: 99%

Psychometric properties of the Treatment-Emergent Activation and Suicidality Assessment Profile (TEASAP) in youth with OCD

Bussing

Murphy

Storch

et al. 2013

Psychiatry Research

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“…Since the introduction of the second‐generation (atypical) antipsychotics (SGA) to clinical practice, many papers on the incidence and prevalence of TD have been published . These works demonstrate a 2.5‐fold decrease in the incidence of TD, to 2%.…”

Section: Current Epidemiologymentioning

confidence: 99%

Tardive dyskinesia (syndrome): Current concept and modern approaches to its management

Lerner

Miodownik

Lerner

2015

Psychiatry Clin Neurosci

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Tardive dyskinesia is a serious, disabling and potentially permanent, neurological hyperkinetic movement disorder that occurs after months or years of taking psychotropic drugs. The pathophysiology of tardive dyskinesia is complex, multifactorial and still not fully understood. A number of drugs were tried for the management of this motor disturbance, yet until now no effective and standard treatment has been found. It is very disappointing to realize that the introduction of antipsychotics from the second generation has not significantly decreased the prevalence and incidence of tardive dyskinesia. Therefore, the management of this motor disturbance remains an actual topic as well as a challenge for clinicians. This review summarizes recent relevant publications concerning the treatment of tardive dyskinesia.

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“…akinesia which is defined as slowness in initiation and execution of willed movement [27], has already been shown by members of our group to be related to neuroleptics with high D 2 affinity compared to atypical antipsychotics [28]. Akinesia has also been shown as a result of D 2 receptor knockout in mice [29].…”

Section: Discussionmentioning

confidence: 96%

Differential Associations of Dopamine-Related Polymorphisms with Discrete Components of Reaction Time Variability: Relevance for Attention Deficit/Hyperactivity Disorder

Grant¹,

Kuepper²,

Wielpuetz³

et al. 2014

Neuropsychobiology

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Background: Reaction time variability (RTV) is considered a valid endophenotype of attention deficit/hyperactivity disorder (ADHD). It is also often used to examine the efficacy of drug treatment or individual patients' treatment responses and has been furthermore suggested to significantly reduce the potential number of false-positive diagnoses. Among the most commonly investigated candidate genes for ADHD are DRD2, SLC6A3 (DAT), COMT and MAOA. Genetic associations have, however, proven inconclusive or inconsistent. Methods: Due to the complexity of dopaminergic neurotransmission in the two distinct prosencephalic dopamine pathways, we examined whether the effects of dopamine-related candidate polymorphisms in the genes DRD2, SLC6A3, COMT and MAOA may be differentially associated with discrete subcomponents of RTV, rather than global RTV. A total of 260 healthy volunteers were genotyped for the aforementioned polymorphisms and performed a reaction time paradigm able to distinguish between sensory and motor reaction time. Results: We found that functional polymorphisms in the genes encoding for dopamine-catabolizing enzymes (i.e. COMT and MAOA) are associated with motor RTV but not with sensory RTV, whereas vice versa the gene DRD2 influences sensory but not motor RTV. No significant associations for the gene SLC6A3 (DAT) were found. Conclusions: Our results give new insight into the inconsistent state of the literature regarding genetic associations of RTV and clearly show that the examination of subcomponents thereof explains far more variance compared to global RTV. This could be of great relevance to the use of RTV in basic research, clinical diagnostics and pharmacological studies examining the efficacy of novel drug treatments.

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Prevalence of movement disorders in adolescent patients with schizophrenia and in relationship to predominantly atypical antipsychotic treatment

Cited by 34 publications

References 84 publications

Psychometric properties of the Treatment-Emergent Activation and Suicidality Assessment Profile (TEASAP) in youth with OCD

Psychometric properties of the Treatment-Emergent Activation and Suicidality Assessment Profile (TEASAP) in youth with OCD

Tardive dyskinesia (syndrome): Current concept and modern approaches to its management

Differential Associations of Dopamine-Related Polymorphisms with Discrete Components of Reaction Time Variability: Relevance for Attention Deficit/Hyperactivity Disorder

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