Prevalence of molar incisor hypomineralization and regional differences throughout Japan

Saitoh, Masato; Nakamura, Yuki; Hanasaki, Mika; Saitoh, Issei; Murai, Yuji; Kurashige, Yoshihito; Fukumoto, Satoshi; Asaka, Yukiko; Yamada, Masaaki; Sekine, Michikazu; Hayasaki, Haruaki; Kimoto, Shigenari

doi:10.1186/s12199-018-0748-6

Cited by 20 publications

(23 citation statements)

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“…However, our results were found to be lower than those reported in Lebanon (26.7%) [ 27 ] and Dubai (27.2%) [ 28 ] but higher than those reported from Nigeria (17.7%) [ 17 ], Kenya (13.7%) [ 16 ], Libya (2.9%) [ 15 ] and Egypt (2.3%) [ 18 ]. There was no difference in the occurrence of MIH with age in this study, in line with results reported by Oydele et al [ 17 ] and Ghanim et al, [ 29 ] but in contradiction with studies that showed significant increase with age by Da costa-Silva et al [ 30 ] and the decrease of MIH with age by Saitoh et al [ 24 ]. In terms of gender, the current study showed boys had slightly higher MIH prevalence than girls, although this was not statistically significant, just as some studies have indicated before [ 24 , 27 ] but contrary to results from other studies where the prevalence were higher for girls [ 16 ] and for boys [ 31 ].…”

Section: Discussionsupporting

confidence: 85%

“…The prevalence of MIH in the current study was 20.1%, which was higher than the mean global prevalence (13.1% to 14.2%) reported in 2018 [13,14], but comparable to results reported in Spain (21.8%) [23], Japan (19.8%) [24], Thailand (20.0%) [25], Iran (20.2%) [26] and Iraq (21.5%) [19]. However, our results were found to be lower than those reported in Lebanon (26.7%) [27] and Dubai (27.2%) [28] but higher than those reported from Nigeria (17.7%) [17], Kenya (13.7%) [16], Libya (2.9%) [15] and Egypt (2.3%) [18].…”

Section: Prevalence Of Mihsupporting

confidence: 68%

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Molar incisor hypomineralization, prevalence, pattern and distribution in Sudanese children

2021

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Background Molar incisor hypomineralization (MIH) has serious impact on oral health-related quality of life for a child, due to its effects on tooth structure, aesthetics and behavior of the child. The current study was designed to determine the prevalence, pattern and distribution of MIH in school children in Sudan. Methods This was a descriptive cross-sectional study involving 568 children, aged 8–11 years from schools in Khartoum State. Following the collection of their socio-demographic data, the children were examined for hypomineralization on the 12 MIH-index teeth, the pattern and distribution of the MIH. The data collected was analyzed to obtain descriptive statistics. The results related to the socio-demography and other dental-related factors were tested using chi-square test and Spearman Rank Correlation, with the significant level set at p < 0.05. Results The prevalence of MIH in the study population was 20.1%. The majority of the participants had both permanent first molars (PFMs) and permanent incisors affected (12.5%). However, in 7.6% of the cases only molars were affected. Even though more maxillary teeth were affected when compared to the mandibular teeth, there was no statistical significant difference between the occurrence of hypomineralization on mandibular and maxillary molars (p = 0.22). Maxillary incisors were significantly more affected by MIH when related to the mandibular ones (p = 0.00). Demarcated opacities were the commonest pattern of MIH defects (69.9%) in the experimental group. Conclusion The prevalence of MIH in Sudanese children was 20.1%. In both dental arches, the permanent molars and incisors were frequently affected, with the demarcated opacity type of MIH being the most common form of defect.

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Section: Discussionsupporting

confidence: 85%

Section: Prevalence Of Mihsupporting

confidence: 68%

Molar incisor hypomineralization, prevalence, pattern and distribution in Sudanese children

2021

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“…The evidence that MIH frequency varies across the world [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] is supported by the results found in the present study. The association found in the Turkish population was different from the results obtained in the cohorts from Brazil, which indeed indicates that genetic factors contributing to the MIH phenotype may vary depending on geographic origin.…”

Section: Plos Onesupporting

confidence: 83%

“…These asymmetrical lesions affect the first permanent molars, usually with the permanent incisors [4], and more recently MIH has been reported to affect canines too [5]. Prevalence of MIH varies but has been consistently reported to range between 1% and 35% in all parts of the world, with most reported frequencies around 12% [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Gene-environment interaction in molar-incisor hypomineralization

et al. 2021

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Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic and environmental factors have been suggested to play roles in MIH’s development, but no conclusive risk factors have shown the source of the disease. During head and neck development, the interferon regulatory factor 6 (IRF6) gene is involved in the structure formation of the oral and maxillofacial regions, and the transforming growth factor alpha (TGFA) is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis. In this present study, it was hypothesized that these genes interact and contribute to predisposition of MIH. Environmental factors affecting children that were 3 years of age or older were also hypothesized to play a role in the disease etiology. Those factors included respiratory issues, malnutrition, food intolerance, infection of any sort and medication intake. A total of 1,065 salivary samples from four different cohorts were obtained, and DNA was extracted from each sample and genotyped for nine different single nucleotide polymorphisms. Association tests and logistic regression implemented in PLINK were used for analyses. A potential interaction between TGFA rs930655 with all markers tested in the cohort from Turkey was identified. These interactions were not identified in the remaining cohorts. Associations (p<0.05) between the use of medication after three years of age and MIH were also found, suggesting that conditions acquired at the age children start to socialize might contribute to the development of MIH.

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“…No difference in the occurrence of MIH with age in this study, in line with results reported by Oydele et al (15), and Ghanim et al, (28) but in contradiction with studies that showed signi cant increase with age by Da costa-Silva et al (29) and decrease with age by Saitoh et al (23). In terms of gender, the current study showed boys had slightly higher MIH prevalence than girls, although this was not statistically signi cant, just as some studies have indicated before (23,26) and contrary to results from other studies where the prevalence were higher for girls (14) and for boys (30).…”

Section: Prevalence Of Mihsupporting

confidence: 81%

Molar Incisor Hypomineralization, prevalence, pattern and distribution in Sudanese children

Abdalla

Abuaffan

Kemoli

2020

Preprint

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Background: Molar incisor hypomineralization (MIH) has serious impact on oral health-related quality of life for a child, due to its effects on tooth structure, aesthetics and behavior of the child. The current study was designed to determine the prevalence, pattern and distribution of MIH in school children in Sudan.Methods: This was a descriptive cross-sectional study involving 568 children, aged 8-11 years from schools in Khartoum State. Following collecting their socio-demographic data, the children were examined for hypomineralization on the 12 MIH indexed teeth, and assessed on the MIH pattern and distribution. The data collected were analyzed to obtain descriptive statistics, and the results related to the socio-demographic and other dental-related factors of the children using chi-square test and Spearman Rank Correlation, with the significant level set at P<0.05.Results: The prevalence of MIH in the study population was 20.1%. The majority of cases had both permanent first molars (PFMs) and permanent incisors affected (12.5%). However, in 7.6% of the cases, only molars were affected. Even though more maxillary teeth were affected when compared to the mandibular teeth, there is no statistical significant difference between the occurrence of hypomineralization on mandibular and maxillary molars (P=0.22). Maxillary incisors were significantly more affected by MIH when related to the mandibular ones (P=0.00). Demarcated opacities were the commonest pattern of MIH defects (69.9%) in the experimental group.Conclusion: The prevalence of MIH in Sudanese children was 20.1%. In both dental arches, the permanent molars and incisors were frequently affected, with the demarcated opacity type of MIH being the most common form of defect. Further studies are recommended to better understand the possible etiologies of MIH in Sudanese children.

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Prevalence of molar incisor hypomineralization and regional differences throughout Japan

Cited by 20 publications

References 19 publications

Molar incisor hypomineralization, prevalence, pattern and distribution in Sudanese children

Molar incisor hypomineralization, prevalence, pattern and distribution in Sudanese children

Gene-environment interaction in molar-incisor hypomineralization

Molar Incisor Hypomineralization, prevalence, pattern and distribution in Sudanese children

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