Prevalence of mitral valve prolapse in primary spontaneous pneumothorax

Abstract

SummaryBackground: Mitral valve prolapse (MVP) has been described as a common diagnosis and has been reported in 50% of patients with primary spontaneous pneumothorax (PSP). The purpose of this study was to determine the prevalence of MVP -as diagnosed by 2D-echocardiography criteria -in spontaneous pneumothorax. Method: A case-control study of 24 patients with PSP, and 40 age-matched controls. All cases underwent 2D-echocardiography by a certified cardiologist. Echocardiography and demographic features of both groups were compared and analyzed using Fisher's exact test. Classic MVP was defined as superior displacement of the mitral leaflets of more than 2 mm during systole and as a maximal leaflet thickness of at least 5 mm during diastasis, and non-classic prolapse was defined as displacement of more than 2 mm with a maximal thickness of less than 5 mm. Results: MVP was found in 9 of the 24 patients (37.5%) who suffered PSP, compared to 3 out of the 40 (7.5%) age-matched controls (P = 0.008). The body mass index (BMI) (weight/height2) was lower in the group with pneumothorax (P = 0.001). Conclusion: In this study, applying an updated definition of MVP, the prevalence of MVP in PSP was lower than previously reported, but was still significantly higher than in the control group.

Primary spontaneous pneumothorax and mitral valve prolapse are not associated

“…Th e association between PSP and MVP was previously reported in three studies performed in Kuwait, Israel, and England [11][12][13]. Th e incidence of MVP in PSP patients was found to be 38% to 81%.…”

“…Microscopically abnormal collagen fi bers and connective tissue of decreased tensile strength have been found in the lung tissue of PSP subjects, and pneumothorax has been suggested to the result of a forme fruste of Marfan syndrome in some cases, whereas MVP might be a further manifestation of a generalized connective tissue abnormality [16,17]. Bitar et al reported a prevalence of 38% for MVP in patients with PSP, compared to only 8% in age-matched controls [11]. However, we found no case of MVP in patients with PSP.…”

“…Th e age, sex, smoking status, BMI, side, rate, and family history were similar to other investigations of PSP. MVP is rare in nonsmokers PSP patients [18] and no higher risk for the smokers [11]. Spontaneous pneumothorax can be one pulmonary complication of connective tissue disease and can be easily overlooked and considered as PSP.…”

Spontaneous pheumothorax and dysplasia of the connecting tissue: phenotype characteristics

“…В основе этого на правления лежали работы по изучению клинического спектра синдрома Марфана, Элерса-Данлоса, гипер мобильности суставов, пролапса митрального клапа на и других ННСТ [13]. Наличие фенотипических маркеров ННСТ, в частности пролапса митрального клапана, было выявлено у ~ 50 % пациентов с первич ным СП сразу в нескольких исследованиях [14,15]. Авторы предположили, что оба состояния являются проявлением одного процесса, связанного с патоло гией соединительной ткани, однако в англоязычной литературе дальнейшего развития данное направле ние не получило.…”

Study of Clinical Profile of Mitral Valve Prolapse

“…[6] thus being more common than a bicuspid aortic valve. The incidence of MVP and risk of complications range greatly, depending on the criteria used for its diagnosis, as well as the patient population studied.…”