Prevalence of Mitral Valve Prolapse in Chronic Lymphocytic Thyroiditis and Nongoitrous Hypothyroidism

Brauman, A; Rosenberg, T.; Gilboa, Yinon; M, Algom; Fuchs, Lior; Schlesinger, Z

doi:10.1159/000174383

Cited by 13 publications

(7 citation statements)

References 17 publications

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“…In hypothyreosis, bradycardia, reversible impairment of myocardial contractility, an increase in peripheral vascular resistance and diastolic hypertension are known, and elevated, low-density lipoprotein (LDL) cholesterol levels too (16). There is also an association of mitral-valve prolapse with auto-immune thyroid diseases (18). Cardiovascular changes have been reported in patients treated with thyrotropin-suppressive doses of thyroxine, including a shortening of the systolic time intervals, a slight increase in the frequency of atrial premature beats and a modest degree of left-ventricular hypertrophy (19 -22), changes that may be counteracted by the concomitant administration of beta-blocking agents (19,20).…”

Section: Resultsmentioning

confidence: 99%

Five-year mortality in men and women with atrial fibrillation

Wändell

2001

Scandinavian Journal of Primary Health Care

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Section: Resultsmentioning

confidence: 99%

Five-year mortality in men and women with atrial fibrillation

Wändell

2001

Scandinavian Journal of Primary Health Care

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“…2 Some studies report an increased prevalence of MVP in heritable connective tissue disorders 3 and in organspecific autoimmune disorders such as autoimmune thyroid diseases. [4][5][6][7] Specifically, in patients with autoimmune thyroid diseases, we have previously reported an increased prevalence of further indices of autoimmunity in the group who also had MVP. 4 Some further studies have also reported an increased frequency of MVP in systemic lupus erythematosus (SLE); 8,9 and recently in Crohn's disease.…”

Section: Introductionmentioning

confidence: 90%

Mitral valve prolapse in young healthy individuals. An early index of autoimmunity?

Evangelopoulos

Toumanidis

Sotou

et al. 2009

Lupus

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Mitral valve prolapse (MVP) is a benign valvular abnormality. However, an increased prevalence of MVP is reported in patients with systemic lupus erythematosus and autoimmune thyroid disease. Our aim was to evaluate whether the presence of MVP in healthy individuals might indicate a premature index of subclinical autoimmune disorder. A total of 75 individuals with MVP and 44 individuals without MVP were identified by echocardiography. Serum samples were examined for various organ and non-organ specific autoantibodies. In all, 35 of the 75 individuals with MVP had at least one autoantibody. ANA were detected in 17/75 in MVP(+) versus 1/44 in the MVP(-), (P < 0.05), and anti-ENA in 6/75 in the MVP(+) versus 0/44 in the control group, P = ns. In the MVP(+) group, thyroid autoantibodies, IgA and IgG RF were found at a statistically significant higher incidence, 16/75, 11/75 and 10/75 versus 1/44, 0/44 and 0/44 in the MVP(-)group, respectively (P < 0.05). The levels of IgG anticardiolipin antibodies were significantly higher in the MVP(+) group, P < 0.05. The presence of organ and non-organ specific autoantibodies in young healthy MVP(+) individuals insinuate the presence of subclinical autoimmunity and might suggest that autoimmune mechanisms might be involved in its pathogenesis. A follow-up of these individuals might elucidate whether MVP constitutes an early index of autoimmunity.

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“…An increased prevalence of MVP has been reported in Graves' disease and chronic lymphocytic thyroiditis, but the pathophysiological mechanisms linking MVP and autoimmune thyroid disease are still not understood. [7][8][9][10][11] In recent years, a germline mutation of the TSHR gene (P639S) was reported to be associated with thyrotoxicosis and MVPS in a Chinese family.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported that the prevalence of MVP is significantly elevated in Graves' disease and chronic lymphocytic thyroiditis, but not in toxic multinodular goiter. [7][8][9][10] The pathophysiological mechanisms linking MVP and autoimmune thyroid disease are still not understood. It has been suggested that human leukocyte antigen genes may explain the linkage between Graves' disease and MVP.…”

mentioning

confidence: 99%

The Polymorphisms of Codon 727 and 52 of Thyroid-Stimulating Hormone Receptor Gene are not Associated with Mitral Valve Prolapse Syndrome in Taiwan Chinese.

Chou¹,

Shi²,

Chang

et al. 2002

Jpn Heart J

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SUMMARYA germline mutation of the thyroid-stimulating hormone receptor (TSHR) gene has been reported to be associated with thyrotoxicosis and mitral valve prolapse syndrome (MVPS) in a Chinese family. The role of TSHR genetic variants in MVPS has not been well studied. This study investigated the possible relationship between the polymorphisms of codon 727 and 52 of the TSHR gene and MVPS among the Chinese population in Taiwan.We studied 100 patients with MVPS diagnosed by echocardiography and 100 ageand sex-matched normal control subjects. The polymorphisms of codon 727 and 52 of the TSHR gene were identified by polymerase chain reaction-based restriction analysis.There was no significant difference in either the genotype distribution or allelic frequencies between MVPS cases and controls for either TSHR gene D727E polymorphism (P=0.51 and 0.45, respectively ) or P52T polymorphism (P=0.60 and 0.31, respectively). The MVPS patients were divided into 2 subgroups: those with Graves' disease, and those without the thyroid disorder, and there were no statistical differences from the controls for both the TSHR gene D727E and P52T polymorphisms. Further categorization of the MVPS patients into mild and severe subgroups also revealed no statistical difference from controls for either the TSHR gene D727E or P52T polymorphisms.These findings suggest that the codon 727 and 52 polymorphisms of the TSHR gene are not the suitable genetic markers of MVPS in Taiwan Chinese. (Jpn Heart J 2002; 43: 655-666)

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Prevalence of Mitral Valve Prolapse in Chronic Lymphocytic Thyroiditis and Nongoitrous Hypothyroidism

Cited by 13 publications

References 17 publications

Five-year mortality in men and women with atrial fibrillation

Five-year mortality in men and women with atrial fibrillation

Mitral valve prolapse in young healthy individuals. An early index of autoimmunity?

The Polymorphisms of Codon 727 and 52 of Thyroid-Stimulating Hormone Receptor Gene are not Associated with Mitral Valve Prolapse Syndrome in Taiwan Chinese.

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