Prevalence of mitral valve insufficiency in cavalier King Charles spaniels

Malik, Rabiya; Hunt, Geraldine B; Allan, G. S.

doi:10.1136/vr.130.14.302

Cited by 17 publications

(14 citation statements)

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“…During this period, the breeding program aimed at reducing the prevalence of MMVD in Swedish CKCS was active. The prevalence of murmurs and indirect MMVD among the six-year-old CKCS was 52% in 2007 and 55% in 2009, which corresponded to findings in earlier studies [3-8]. Before the breeding program was introduced in Sweden, the prevalence of MMVD in six-year-old CKCS was 35.5% (27% for females and 44% for males), based on a previous study between 1985-1991 [5].…”

Section: Discussionsupporting

confidence: 82%

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Evaluation of the Swedish breeding program for cavalier King Charles spaniels

Lundin¹,

Kvart

2010

Acta Vet Scand

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A breeding program with the aim of reducing the prevalence of mitral regurgitation (MR) caused by myxomatous mitral valve disease (MMVD) in Cavalier King Charles Spaniels (CKCS) is currently ongoing in Sweden. In this investigation 353 CKCS were selected as a sample of the population and 150 were examined by auscultation for heart murmurs when they reached the age of six years in 2007 and 2009. The aim with this investigation was to study the prevalence of heart murmurs in six-year-old CKCS and to estimate if prevalence has decreased since the breeding program was introduced 2001. The effect of the breeding program was evaluated by comparing the prevalence of heart murmurs in the two groups. In 2007, the prevalence of heart murmurs was 52% (50% for females and 54% for males) and in 2009, the prevalence was 55% (44% for females and 67% for males). No significant difference was found in the prevalence of heart murmurs between 2007 and 2009 (P = 0.8). For all six-year-old CKCS, the prevalence of heart murmur was 53% (females 46% and males 61%), which is higher than previous Swedish investigations.

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Section: Discussionsupporting

confidence: 82%

“…In CKCS onset is early with a high prevalence of MR caused by MMVD, and at the age of 6-7 years, murmur prevalence is approximately 50%. At the age of 11 years, almost 100% of CKCS have developed MMVD [3-8]. …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Swedish breeding program for cavalier King Charles spaniels

Lundin¹,

Kvart

2010

Acta Vet Scand

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“…39 However, 5 of 6 Cavaliers > 10 years old in that study had mitral murmurs, suggesting that CKCS in Australia may have a later onset of the disease. These differences could be related to different breeding lines in different countries.…”

Section: Chfmentioning

confidence: 70%

Historical review, epidemiology and natural history of degenerative mitral valve disease

Borgarelli

Buchanan

2012

Journal of Veterinary Cardiology

158

154

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“…1,2 As observed in humans, 26 this higher prevalence occurs mainly in old rather than in young dogs 3 and has sometimes been observed in Cavalier King Charles spaniels 27 but not systematically. 5,6,13,15 Insufficient statistical power in some studies or the particularities of certain breeds might explain these discrepancies. Unfortunately, the origin of a critical sex 27 The present study also demonstrates that the development of MVD in the main small breeds of dogs in France occurs with closed prevalence, compared to the ''accelerated'' disease observed in Cavalier King Charles spaniels.…”

Section: Discussionmentioning

confidence: 99%