Prevalence of microvascular complications in newly diagnosed patients with Type 2 diabetes

Ali, Alia; Iqbal, Farrukh; Taj, Azeem; Iqbal, Zafar; Amin, Muhammad Joher; Iqbal, Qasim Z

doi:10.12669/pjms.294.3704

Cited by 59 publications

(57 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients with higher fasting blood sugar had higher risk of developing complications. Findings from other studies also support that higher blood glucose is related to microvascular complications (Klien, 1995;Cade, 2008;Group, 1998;Cardoso and Salles 2008;Nazimek-Siewniak et al, 2002;Ali et al, 2013; Glycemic control is the primary mediator of diabetic microvascular complications.…”

Section: Figure 2 Graphical Evaluation Of Weibull Model and Proportimentioning

confidence: 61%

Correlates of time to microvascular complications among diabetes mellitus patients using parametric and non-parametric approaches: a case study of Ayder referral hospital, Ethiopia

Berihun¹,

Muluneh²

2017

Eth J Sci & Technol

View full text Add to dashboard Cite

Socio-demographic and clinical factors have been known to affect the time to microvascular complications and survival probabilities of diabetes mellitus patients. The objective of this study was to identify risk factors and estimate average survival times for the time to the development of microvascular complications of diabetic patients under follow up at Ayder referral hospital from February 2011 to January 2014. A retrospective follow up study was conducted on diabetic patients during this treatment period of 3 years. Using simple random sampling a total of 277 patients were included in the study. Cox and Weibull proportional hazards models were used to identify risk factors for the time to microvascular complications. Results showed that the prevalence of microvascular complication during the follow up period in the studied population was 42.6% and was more prevalent in women. The estimated overall median survival time was 425 days. Factors associated with increased risk of microvascular complications among the sampled diabetes mellitus patients as identified by the Weibull model were older age (HR=1.025, 95% CI: 1.008-1.043, p=0.003), female sex (HR=1.531, 95% CI: 1.063-2.206, p=0.002), Type 2 diabetes (HR=2.320, 95% CI: 1.121-4.799, p=0.023) and fasting blood sugar (FBS) (HR=1.006, 95% CI: 1.003-1.008, p=0.0000). The results suggest strongly that to minimize the risk of diabetic complications it is necessary to treat blood glucose aggressively.

show abstract

Section: Figure 2 Graphical Evaluation Of Weibull Model and Proportimentioning

confidence: 61%

Correlates of time to microvascular complications among diabetes mellitus patients using parametric and non-parametric approaches: a case study of Ayder referral hospital, Ethiopia

Berihun¹,

Muluneh²

2017

Eth J Sci & Technol

View full text Add to dashboard Cite

show abstract

“…Studies have reported the existence of a strong correlation between hyperglycemia and the presence of microvascular complications [5,6], for example, retinopathy [7,8], nephropathy [8,9], and diabetic neuropathy [10]. Macrovascular complications [5,11], which represent the leading cause of death in DM2 [7,12], have been associated with poor glycemic control [13] and blood oxidative stress (BLOS) [14].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress in patients with type 2 diabetes mellitus treated with metformin

Dries¹,

Soares

Ziulkoski

et al. 2017

Sci Med

View full text Add to dashboard Cite

AIMS: To evaluate oxidative stress parameters in patients with type 2 diabetes mellitus treated with metformin, relating these values to its side effects, plasma levels, glycemic control, diabetic complications, lipid profile, and the influence of pharmacotherapeutic follow-up. METHODS: Patients with type 2 diabetes mellitus, on metformin and in pharmacotherapeutic follow-up for four months, were evaluated. The pharmacotherapeutic follow-up consisted in providing information and answering patients' questions about medication and disease. In addition, administration times, dosages, and presence or absence of side effects related to the use of metformin were verified. Glycemic and lipid profile, oxidative stress (superoxide dismutase and malondialdehyde) and plasma metformin were evaluated. Pearson's correlation and Spearman's correlation were performed to evaluate the relationship between the variables at the beginning of the study. The independent t-test and Mann-Whitney U test were used to assess the difference between the groups with and without diabetic complications. The range of values between the beginning and end of the study was evaluated using Student's t-test or Wilcoxon U test. The significance level was set at 5%. RESULTS: The initial sample consisted of 49 patients aged 59±9 years with a body mass index of 29.8±5.1 kg/m 2 , who have had diabetes for a median time of 36 months (interquartile range of 1-240) and have been on metformin for a median time of 36 months (interquartile range of 1-180). Twenty-five patients left the study between the second and fourth meetings. Malondialdehyde levels differed between before and after pharmacotherapeutic follow-up, being positively correlated with blood glucose, glycohemoglobin, and triglyceride level, and negatively correlated with metformin and superoxide dismutase. Blood glucose, glycohemoglobin, and malondialdehyde levels increased, whereas metformin levels decreased in the group with diabetic complications, and there was a correlation between malondialdehyde and the number of diabetic complications per patient. CONCLUSIONS: In this sample of patients with type 2 diabetes mellitus treated with metformin, oxidative stress was more pronounced in those with poor glycemic control and diabetic complications.KEY WORDS: diabetes mellitus; oxidative stress; superoxide dismutase; malondialdehyde; metformin; diabetic complications. RESUMOOBJETIVOS: Avaliar parâmetros de estresse oxidativo em pacientes com diabetes mellitus tipo 2 em uso de metformina, relacionando estes valores a seus efeitos adversos, níveis plasmáticos, controle glicêmico, complicações diabéticas, perfil lipídico, e a influência do acompanhamento farmacoterapêutico. MÉTODOS: Foram avaliados pacientes com diabetes mellitus tipo 2, em uso de metformina, em acompanhamento farmacoterapêutico por quatro meses. O acompanhamento farmacoterapêutico consistiu na prestação de informações e no esclarecimento de dúvidas dos pacientes sobre a medicação e a doença. Além disto, foram verificados os horá...

show abstract

“…Our findings are in line with reports from recent population studies in which the prevalence of diabetic retinopathy ranged from 6% to 23%. 14,15 The lowest estimates (6.2% in Australia 16 and 10.2% in the USA 17 come from studies that undertook simultaneous diabetes diagnosis and retinal screening. These differences in prevalence of retinopathy in newly diagnosed type 2 diabetics might be due to variable time interval between onset and detection of the disease.…”

Section: Discussionmentioning

confidence: 99%

Glycaemic status is an important risk factor for the occurrence of diabetic retinopathy in newly diagnosed type 2 diabetic patients

et al. 2015

View full text Add to dashboard Cite

Objective:To assess the frequency of diabetic retinopathy (DR) and correlation with HbA1c in newly diagnosed type 2 diabetic patients. Materials and Methods: The study was conducted at a tertiary care medical centre in north India. All patients of >30 to <60 years of age, who were newly (within a month) diagnosed type 2 diabetes mellitus, according to World Health Organization (WHO) criteria and American Diabetes Association (ADA) recommendations, were included in the study. HbA1c was estimated from venous blood collected in ethylene diamine tetra acetic acid (EDTA) test tube, using boronate affinity chromatography (HPLC). Diabetic retinopathy was assessed by fundus examination using direct ophthalmoscope after dilatation of pupils. Early treatment diabetic retinopathy study (ETDRS) scale was used to assess the severity of diabetic retinopathy. Results: Twenty-eight percent of the newly diagnosed cases were found to have diabetic retinopathy, of which 73.52% were of mild NPDR (non-proliferative diabetic retinopathy) and 26.47% were of moderate NPDR. Mean FPG of population with retinopathy was 194.05 ±29.82 mg/dl and that of population without retinopathy was 175.67 ± 27.71mg/dl. Mean HbA1c of population with retinopathy was 7.71±1.01%and that of population without retinopathy was 7.22 ± 0.74. Conclusions: Mild NPDR is the most common form of diabetic retinopathy in newly diagnosed type 2 DM patients. Study demonstrated a very significant positive correlation between level of glycosylated hemoglobin (HbA1c) and frequency of diabetic retinopathy in these cases. So, glycaemic status is an important risk factor for the occurrence of diabetic retinopathy.

show abstract

Prevalence of microvascular complications in newly diagnosed patients with Type 2 diabetes

Cited by 59 publications

References 21 publications

Correlates of time to microvascular complications among diabetes mellitus patients using parametric and non-parametric approaches: a case study of Ayder referral hospital, Ethiopia

Correlates of time to microvascular complications among diabetes mellitus patients using parametric and non-parametric approaches: a case study of Ayder referral hospital, Ethiopia

Oxidative stress in patients with type 2 diabetes mellitus treated with metformin

Glycaemic status is an important risk factor for the occurrence of diabetic retinopathy in newly diagnosed type 2 diabetic patients

Contact Info

Product

Resources

About