Prevalence of micronutrient deficiency particularly of iron, zinc and folic acid in pregnant women in South East Asia

Seshadri, Subadra

doi:10.1049/bjn2000299

Cited by 62 publications

(47 citation statements)

References 25 publications

(34 reference statements)

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“…Although global folate deficiency prevalence numbers appear uncertain (Lindenbaum and Allen, 1995), prevalence studies have been conducted in individual countries. Nearly 40e50% of pregnant women in India may suffer from some degree of folate deficiency (Seshadri, 2001); approximately 8000 severe birth defects reported, including infantile paralysis, are seen annually due to folate deficiency in Bangladesh. It also is a suspected cause for the increase in deaths from heart disease and stroke (Micronutrient Initiative and UNICEF, 2011).…”

Section: Introductionmentioning

confidence: 99%

Fortification of rice with folic acid using parboiling technique: Effect of parboiling conditions on nutrient uptake and physical characteristics of milled rice

Kam¹,

Arcot²,

Ward³

2012

Journal of Cereal Science

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Section: Introductionmentioning

confidence: 99%

Fortification of rice with folic acid using parboiling technique: Effect of parboiling conditions on nutrient uptake and physical characteristics of milled rice

Kam¹,

Arcot²,

Ward³

2012

Journal of Cereal Science

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“…Deficiency of the minerals in women of reproductive age is recognized as a major public health problem in many developing countries [3][4][5][6][7]. Pregnant women are particularly vulnerable to nutritional deficiencies because of the increased metabolic demands imposed by pregnancy involving a growing placenta, fetus, and maternal tissues, coupled with associated dietary risks [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Maternal iron deficiency and the consequent anemia comprise a major problem in developing countries, affecting >50% of women during pregnancy [5,6]. Other micronutrient deficiencies are likely to be widely prevalent, especially those of iodine, zinc, and vitamin A [1,8,9].…”

Section: Introductionmentioning

confidence: 99%

Serum Zinc, Copper, Selenium, Calcium, and Magnesium Levels in Pregnant and Non-Pregnant Women in Gondar, Northwest Ethiopia

Kassu

Yabutani

Mulu

et al. 2008

Biol Trace Elem Res

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Pregnant women in developing countries are vulnerable to multiple micronutrient deficiencies. Studies assessing serum levels of the micronutrients and magnitude of their deficiencies are very scarce in African subjects. This study was aimed at determining serum levels of micronutrients in 375 pregnant (42 HIV seropositive) and 76 non-pregnant women (20 HIV seropositive) who visited the University of Gondar Hospital, Gondar, Ethiopia. Serum concentrations of zinc,\ copper, selenium, calcium, and magnesium were determined using an inductively coupled plasma mass spectrometer. Irrespective of HIV serostatus, pregnant women had significantly higher serum concentrations of copper and copper/zinc ratio and significantly lower magnesium compared to those in non-pregnant women (P < 0.05). Except for selenium, which was significantly lower in HIV-seropositive pregnant women (P < 0.05), the mean serum concentrations of zinc, copper, calcium, and magnesium were not significantly different between pregnant women by HIV serostatus. The prevalence of deficiency in zinc, magnesium, selenium, and calcium in the pregnant women, irrespective of their HIV serostatus, was 66.7%, 25.6%, 21.9%, and 9.3%, respectively. The magnitude of deficiency in zinc, magnesium, and selenium was significantly higher in HIV seropositive pregnant women (76.2%, 52.4%, and 45.2%) than that in HIV-seronegative pregnant women (65.5%, 22.2%, and 18.9%) and in HIV-seronegative non-pregnant women (42.9%, 8.1%, and 30.4%; P < 0.05). Deficiency in one, two, three, or four mineral elements was observed in 44.8%, 14.4%, 9.9%, and 5.1% of the pregnant women, respectively. Only 25.9% of the pregnant women and 44.7% of the non-pregnant women were not deficient in any of the micronutrients. The high prevalence of micronutrient deficiencies in pregnant and non-pregnant women in Gondar, Ethiopia warrants the need for strategies on prevention and control of the deficiencies.

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“…The prevalence of folic acid deficiency may be up to 30-50% in pregnant women, and benzene from cook stoves and Downloaded by [Flinders University of South Australia] at 23:53 03 January 2015 automobile exhausts have been a cause for concern in developing countries in South East Asia (18)(19)(20). People with a low folate status, such as pregnant women, may be at high risk of chromosomal damage.…”

Section: Introductionmentioning

confidence: 99%

Low Folate Status Enhanced Benzene-Induced Cytogenetic Damage in Bone Marrow of Mice: A Relationship Between Dietary Intake and Tissue Levels of Folate

Endoh

Murakami

Sugiyama

et al. 2007

Nutrition and Cancer

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We examined the protective effect of dietary folate on benzene-induced chromosomal damage in bone marrow of mice regarding folate levels in diet and tissue. Male mice were fed either a deficient, basal, or high folate diet (0, 2, or 8 mg/kg diet, respectively) for 4 wk followed by a single dose of benzene. Plasma folate levels corresponded to those of dietary intake. Meanwhile, bone marrow, erythrocyte, and liver folate were decreased to 40% in the deficient group and almost saturated in the high group. Plasma homocysteine levels negatively correlated to levels of tissue folate. Chromosomal damage, evaluated by micronucleus assay, was not affected by folate status alone but was markedly enhanced by benzene, particularly in the deficient group (P < 0.05 vs. the basal and high groups). The activities of hepatic drug-metabolizing enzymes did not enhance benzene metabolism in the deficient groups, indicating that enhanced chromosomal damage was solely due to the low folate status. These results suggest that a low folate status can increase the risk of benzene-induced chromosomal damage in bone marrow, but excess folate intake does not enhance protection, as it is saturated in tissue.

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Prevalence of micronutrient deficiency particularly of iron, zinc and folic acid in pregnant women in South East Asia

Cited by 62 publications

References 25 publications

Fortification of rice with folic acid using parboiling technique: Effect of parboiling conditions on nutrient uptake and physical characteristics of milled rice

Fortification of rice with folic acid using parboiling technique: Effect of parboiling conditions on nutrient uptake and physical characteristics of milled rice

Serum Zinc, Copper, Selenium, Calcium, and Magnesium Levels in Pregnant and Non-Pregnant Women in Gondar, Northwest Ethiopia

Low Folate Status Enhanced Benzene-Induced Cytogenetic Damage in Bone Marrow of Mice: A Relationship Between Dietary Intake and Tissue Levels of Folate

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