Prevalence of micronutrient deficiency and its impact on the outcome of childhood cancer: A prospective cohort study

Ganguly, Shuvadeep; Srivastava, Richa; Agarwala, Sandeep; Dwivedi, Supriya; Bansal, Priyanka Gupta; Gonmei, Zaozianlungliu; Toteja, Gurdayal Singh; Dhawan, Deepa; Bakhshi, Sameer

doi:10.1016/j.clnu.2022.05.010

Cited by 10 publications

(9 citation statements)

References 40 publications

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“…18,19 However, other reports demonstrated that low folate level at diagnosis is a poor prognostic factor in leukemia. 3,4 Depleted antioxidant levels have been reported in the treatment of leukemia and solid tumor patients. 20 Any supplementation that has antioxidant potential is currently not recommended.…”

Section: Discussionmentioning

confidence: 99%

“…Cancer survival is affected by micronutrient deficiency in several reports 4–6 . Mucositis has been linked to vitamin A and D deficiency 6–8 .…”

Section: Discussionmentioning

confidence: 99%

“…Cancer survival is affected by micronutrient deficiency in several reports. [4][5][6] Mucositis has been linked to vitamin A and D deficiency. [6][7][8] Vitamin D is the most frequently documented micronutrient associated with a poorer outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies in the general pediatric population have documented that many children are deficient in numerous micronutrients, which can result in specific clinical pathology 3 . Micronutrient deficiency may affect event‐free survival, exacerbate chemotherapy toxicity, and increase adverse events 4–6 . We conducted a feasibility study measuring six micronutrient levels at diagnosis and after 6 months of chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Feasibility study of micronutrient status and body mass index of newly diagnosed pediatric oncology patients: Research commentary

Rogers,

Cheng,

Lim

et al. 2024

Pediatric Blood & Cancer

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We conducted a feasibility study to evaluate micronutrients and body mass index (BMI). Fat soluble vitamins A, D, E and trace elements copper (Cu), selenium (Se), and zinc (Zn) levels were evaluated. Weight, height, BMI, and Z‐scores were recorded. Side effects or specific adverse events were documented. No patient had a Z‐score for height, weight, or BMI of less than 2 SD or greater than 2 SD. Ninety percent of patients had one or more micronutrient levels below normal. These results suggest that micronutrient abnormalities are common despite no obvious evidence of malnutrition. Side effects of chemotherapy may be exacerbated by micronutrient depletion.

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Section: Discussionmentioning

confidence: 99%

“…Cancer survival is affected by micronutrient deficiency in several reports 4–6 . Mucositis has been linked to vitamin A and D deficiency 6–8 .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Feasibility study of micronutrient status and body mass index of newly diagnosed pediatric oncology patients: Research commentary

Rogers,

Cheng,

Lim

et al. 2024

Pediatric Blood & Cancer

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“…Their deficiency has been linked to several risks, such as failure to thrive, delayed psychomotor development, megaloblastic anemia [ 82 , 83 ], and, recently, poor event-free survival in cancer [ 84 ]. Moreover, low levels can cause DNA synthesis interference, cellular inflammation, elevated synthesis of fat, and hyperhomocysteinemia, an independent risk factor for insulin resistance and cardiovascular disease [ 85 , 86 ].…”

Section: Micronutrients Deficiency In Childhood Obesitymentioning

confidence: 99%

Micronutrient Deficiency in Children and Adolescents with Obesity—A Narrative Review

et al. 2023

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Childhood obesity represents a serious public health burden. Despite excessive dietary consumption, children with obesity present high rates of micronutrient deficiencies, such as deficiencies in minerals and specific vitamins; micronutrient deficiencies may have a pathogenic role in obesity-related metabolic comorbidities. In this narrative review, we analyzed the main deficiencies associated with obesity, their clinical consequences, and the evidence about a possible supplementation. Iron; vitamins A, B, C, D, and E; folic acid; zinc; and copper deficiencies represent the most common deficient microelements. The relationship between obesity and multiple micronutrient deficiencies remains unclear, and different mechanisms have been proposed. The medical care plan for pediatric obesity should include food choices with high nutritional content as part of a crucial approach to obesity-related complications. Unfortunately, only a few studies are available regarding the efficacy of oral supplementation or weight loss for treating them; thus, continuous nutritional monitoring is necessary.

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Zinc Deficiency as a General Feature of Cancer: a Review of the Literature

Sugimoto,

Lee,

Tanaka

et al. 2023

Biol Trace Elem Res

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Trace elements are minerals that are present in very low concentrations in the human body and yet are crucial for a wide range of physiological functions. Zinc, the second most abundant trace element, is obtained primarily from the diet. After being taken up in the intestine, zinc is distributed to various target organs, where it plays key roles in processes such as immunity, protein folding, apoptosis, and antioxidant activity. Given the important role of zinc in a wide range of enzymatic reactions and physiological processes, zinc deficiency has been identified in a variety of diseases, notably cancer. In recent years, multiple meta-analyses and reviews looking at zinc levels in individual cancer types have been published, as have a plethora of primary studies demonstrating a link between low zinc levels and specific types of cancer. In this review, we summarize recent evidence implicating low zinc concentrations in serum or tissues as a characteristic in a wide range of cancers. We also discuss preliminary findings indicating that zinc level measurement could ultimately become a useful clinical tool for cancer diagnosis and predicting outcomes in patients with cancer. Finally, we suggest future directions for further elucidating the role of zinc deficiency in cancer development and progression.

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Prevalence of micronutrient deficiency and its impact on the outcome of childhood cancer: A prospective cohort study

Cited by 10 publications

References 40 publications

Feasibility study of micronutrient status and body mass index of newly diagnosed pediatric oncology patients: Research commentary

Feasibility study of micronutrient status and body mass index of newly diagnosed pediatric oncology patients: Research commentary

Micronutrient Deficiency in Children and Adolescents with Obesity—A Narrative Review

Zinc Deficiency as a General Feature of Cancer: a Review of the Literature

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