Prevalence of methicillin-resistant Staphylococcus aureus isolated from burn patients in Iran: A systematic review and meta-analysis

Emaneini, Mohammad; Beigverdi, Reza; Leeuwen, Willem B. van; Rahdar, Hosseinali; Karami‐Zarandi, Morteza; Hosseinkhani, Farideh; Jabalameli, Fereshteh

doi:10.1016/j.jgar.2017.10.015

Cited by 26 publications

(22 citation statements)

References 23 publications

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“…At present, the widespread use of these antibiotics in treatment of infections caused by S. aureus has led to the emergence of MLSB-resistant strains [19,20]. In this study, 79% of the isolated S. aureus strains was identified as MRSA by the application of the cefoxitin disk and oxacillin-salt agar screening, which is comparable to the 77.9% prevalence of MRSA in Iranian burn patients [21]. In a study from capital of Iran, Abbasian et al [22] reported prevalence rate of 64.2% for MRSA in a burn hospital.…”

Section: Discussionsupporting

confidence: 50%

“…The prevalence rate of MRSA in Iranian burn centers is different in various regions. However, several studies revealed the increasing prevalence of MRSA in our country [21]. These inconsistencies in the prevalence of MRSA among various regions might be due to the different antibiotic use patterns and dissimilar infection control strategies [22].…”

Section: Discussionmentioning

confidence: 89%

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Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among methicillin-resistant Staphylococcus aureus strains isolated from burn patients

Khoshnood

Shahi

Jomehzadeh³

et al. 2019

AMicr

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The increasing resistance to macrolide, lincosamide, and streptogramin B agents among methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide problem for the health community. This study aimed to investigate the prevalence of ermA, ermB, ermC, and msrA in MRSA strains isolated from burn patients in Ahvaz, southwest of Iran. A total of 76 isolates of S. aureus were collected from January to May 2017 from Taleghani Burn Hospital in Ahvaz. Among 76 S. aureus strains collected, 60 (78.9%) isolates were MRSA. The antimicrobial susceptibility testing for MRSA showed extreme high resistance rate to clarithromycin (100%) and azithromycin (100%), followed by erythromycin (98.3%). The PCR assay revealed that the frequency rates of msrA, ermA, and ermC genes were 23 (38.3%), 28 (46.7%), and 22 (36.7%), respectively. In addition, none of the MRSA isolates had the ermB gene. Because of the high prevalence of macrolide and lincosamide resistance found in MRSA isolates from infections of burn patients in Ahvaz, southwest of Iran, it is recommended that local periodic survey be performed for controlling the dissemination of antimicrobial resistance.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 89%

Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among methicillin-resistant Staphylococcus aureus strains isolated from burn patients

Khoshnood

Shahi

Jomehzadeh³

et al. 2019

AMicr

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“…Furthermore, infections with multidrug-resistant bacteria are occurring more frequently, and few or no drugs are available to combat them (Boucher et al, 2009 ; Wright, 2016 ; Gonzalez-Bello, 2017 ). One of the major multidrug-resistant bacteria is methicillin-resistant Staphylococcus aureus (MRSA), which is recognized as a leading cause of nosocomial infections (Shahsavan et al, 2012 ; Emaneini et al, 2017 ). Persisters are a small non-growing population of bacteria which could also escape from different antibiotics (Levin and Rozen, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Gas Plasma Pre-treatment Increases Antibiotic Sensitivity and Persister Eradication in Methicillin-Resistant Staphylococcus aureus

Guo

Zhao

et al. 2018

Front. Microbiol.

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Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of serious nosocomial infections, and recurrent MRSA infections primarily result from the survival of persister cells after antibiotic treatment. Gas plasma, a novel source of ROS (reactive oxygen species) and RNS (reactive nitrogen species) generation, not only inactivates pathogenic microbes but also restore the sensitivity of MRSA to antibiotics. This study further found that sublethal treatment of MRSA with both plasma and plasma-activated saline increased the antibiotic sensitivity and promoted the eradication of persister cells by tetracycline, gentamycin, clindamycin, chloramphenicol, ciprofloxacin, rifampicin, and vancomycin. The short-lived ROS and RNS generated by plasma played a primary role in the process and induced the increase of many species of ROS and RNS in MRSA cells. Thus, our data indicated that the plasma treatment could promote the effects of many different classes of antibiotics and act as an antibiotic sensitizer for the treatment of antibiotic-resistant bacteria involved in infectious diseases.

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“…Staphylococcus aureus ( S. aureus ) is one of the most common causes of infection among patients with severe burn wounds [1, 2]. Colonization of burn wounds with S. aureus can cause septicemia and substantially increase mortality rate [3].…”

Section: Introductionmentioning

confidence: 99%

High prevalence of direct repeat unit types of 10di, 8 h and 8i among methicillin resistant Staphylococcus aureus strains with staphylococcal cassette chromosome mec type IIIA isolated in Tehran, Iran

Motallebi

Jabalameli

Beigverdi

et al. 2019

Antimicrob Resist Infect Control

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Background The emergence of methicillin-resistant Staphylococcus aureus (MRSA) is a main concern in burn care centers worldwide. The some reports of MRSA in Iran suggested that MRSA with type SCC mec III is common among burn patients. The aim of this study was to determine the prevalence, virulence genes, and antimicrobial susceptibility of the direct repeat units ( dru ) types of MRSA with SCC mec IIIA isolated from burn wounds in a burn care center in Tehran, Iran. Methods In total, 165 S. aureus isolates were collected from clinical samples. In order to detect MRSA isolates, the mec A gene was amplified through the polymerase chain reaction (PCR) method. Antimicrobial susceptibility was tested using the disc agar diffusion test. Moreover, the PCR method was applied to determine SCC mec types, virulence genes, and antimicrobial resistance genes. The dru region was sequenced and thereby, dru types and dru repeats were identified. A similarity matrix was used to create minimum spanning tree (MST). Results The prevalence of MRSA was 69% (114 out of 165 isolates). Most of MRSA isolates (61 out of 114, 53.5%) were SCC mec type IIIA. All MRSA isolates were vancomycin-susceptible and more than 68% of MRSA isolates with SCC mec type IIIA were mupirocin resistant. The successful dru typing of isolates with SCC mec type IIIA revealed fourteen different dru types. There were two new dru types, namely dt10di and dt7aj. MST analysis indicated the presence of the three clusters of dt10di (cluster I), dt8i-dt8 h (cluster II), and dt11c-dt10ao-dt11dd-dt11a-dt10a (cluster III). There were significant differences between clusters I and II respecting antimicrobial resistance pattern and virulence genes. Conclusion Three main dru clusters are prevalent in the study setting. The main dru types in the setting are dt10di, dt8i, and dt8 h. Dru typing can be used to differentiate MRSA strains with SCC mec IIIA.

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Prevalence of methicillin-resistant Staphylococcus aureus isolated from burn patients in Iran: A systematic review and meta-analysis

Cited by 26 publications

References 23 publications

Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among methicillin-resistant Staphylococcus aureus strains isolated from burn patients

Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among methicillin-resistant Staphylococcus aureus strains isolated from burn patients

Gas Plasma Pre-treatment Increases Antibiotic Sensitivity and Persister Eradication in Methicillin-Resistant Staphylococcus aureus

High prevalence of direct repeat unit types of 10di, 8 h and 8i among methicillin resistant Staphylococcus aureus strains with staphylococcal cassette chromosome mec type IIIA isolated in Tehran, Iran

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