Prevalence of methanogens and associated factors in patients with irritable bowel syndrome and healthy controls in a Southeastern Mexican population

Aja-Cadena, Marco; Amieva-Balmori, Mercedes; Taboada-Liceaga, Héctor A.; Cobos-Quevedo, Orestes; Hernández-Ramírez, G.A.; Reyes-Huerta, Job; Roesch-Dietlen, F.; Meixuerio-Daza, A.; Remes-Troche, J.M.

doi:10.1016/j.rgmxen.2021.11.013

Cited by 1 publication

(1 citation statement)

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“…Moreover, from all taxa that were different among IBS subtypes in Mexican samples, Streptococcus was the only one correlated with age and BMI. Although the relationship between Streptococcus and methane metabolism is not well studied, the finding of lower Streptococcus in Mexican samples with IBS-C is interesting in the context of the findings presented by Aja-Cadena et al [43] that used a patient population from the same area and showed that IBS-C patients had a greater methanogenic propensity. This is in line with previous findings [44].…”

Section: Discussionmentioning

confidence: 86%

Fecal Microbial Composition and Predicted Functional Profile in Irritable Bowel Syndrome Differ between Subtypes and Geographical Locations

Garcia-Mazcorro,

Amieva-Balmori,

Triana-Romero

et al. 2023

Microorganisms

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Increasing evidence suggests a microbial pathogenesis in irritable bowel syndrome (IBS) but the relationship remains elusive. Fecal DNA samples from 120 patients with IBS, 82 Mexican (IBS-C: n = 33, IBS-D: n = 24, IBS-M: n = 25) and 38 British (IBS-C: n = 6, IBS-D: n = 27, IBS-M: n = 5), were available for analysis using 16S rRNA gene sequencing. Firmicutes (mean: 82.1%), Actinobacteria (10.2%), and Bacteroidetes (4.4%) were the most abundant taxa. The analysis of all samples (n = 120), and females (n = 94) only, showed no significant differences in bacterial microbiota, but the analysis of Mexican patients (n = 82) showed several differences in key taxa (e.g., Faecalibacterium) among the different IBS subtypes. In IBS-D there were significantly higher Bacteroidetes in British patients (n = 27) than in Mexican patients (n = 24), suggesting unique fecal microbiota signatures within the same IBS subtype. These differences in IBS-D were also observed at lower phylogenetic levels (e.g., higher Enterobacteriaceae and Streptococcus in Mexican patients) and were accompanied by differences in several alpha diversity metrics. Beta diversity was not different among IBS subtypes when using all samples, but the analysis of IBS-D patients revealed consistent differences between Mexican and British patients. This study suggests that fecal microbiota is different between IBS subtypes and also within each subtype depending on geographical location.

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Section: Discussionmentioning

confidence: 86%