Prevalence of metabolic syndrome, insulin resistance, and microvascular angina pectoris in 500 consecutive patients referred to coronarography

Hrnciar, J; Avdicova, M; Gábor, D; Hrnciarová, M; Chamulová, M; Kaliská, Gabriela; Kikova,; Kovář, František; Kréze, A; Lepej, J; Okapcová, J; Szentiványi, M.

doi:10.4149/endo_2013_01_33

Cited by 8 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Human MetS has been associated with an increased risk of CVD such as myocardial infarction, stroke [40], and coronary microvascular dysfunction linked to a microvascular form of angina pectoris [11]. Microvascular dysfunction is reported to be associated with poor cardiovascular outcomes [41,42], including left ventricular remodeling [43].…”

Section: Discussionmentioning

confidence: 99%

Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet

Aoqui

Chmielewski

Scherer

et al. 2014

Cardiovasc Diabetol

View full text Add to dashboard Cite

BackgroundMetabolic syndrome (MetS) is associated with increased risk of cardiovascular disease (CVD). One important feature underlying the pathophysiology of many types of CVD is microvascular dysfunction. Although components of MetS are themselves CVD risk factors, the risk is increased when the syndrome is considered as one entity. We aimed to characterize microvascular function and some of its influencing factors in the course of MetS development.MethodsDevelopment of MetS in C57BL/6 mice on a high-fat diet (HFD, 51% of energy from fat) was studied. The initial phase of MetS (I-MetS) was defined as the first 2 weeks of HFD feeding, with the fully developed phase occurring after 8 weeks of HFD. We characterized these phases by assessing changes in adiposity, blood pressure, and microvascular function. All data are presented as mean ± standard error (SEM). Differences between cumulative dose–response curves of myograph experiments were calculated using non-linear regression analysis. In other experiments, comparisons between two groups were made with Student’s t-test. Comparisons between more than two groups were made using one-way ANOVA with Tukey post-hoc test. A probability value <0.05 was considered statistically significant.ResultsI-MetS mice presented with weight gain, blood pressure elevation, and microvascular dysfunction characterized by augmented vasoconstriction. This finding, contrary to those in mice with fully developed MetS, was not associated with endothelial dysfunction, insulin resistance, or systemic inflammation. In the initial phase, perivascular adipose tissue showed no sign of inflammation and had no influence on the pattern of vasoconstriction. These findings suggest that the onset of hypertension in MetS is strongly influenced by vascular smooth muscle cell dysfunction and independent of important factors known to influence microvascular function and consequently blood pressure levels.ConclusionWe identified in I-MetS the occurrence of isolated augmented vasoconstriction along with blood pressure elevation, but not the presence of classical MetS components known to influence microvascular function. These findings increase our understanding of the pathophysiology of CVD risk associated with MetS.

show abstract

Section: Discussionmentioning

confidence: 99%

Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet

Aoqui

Chmielewski

Scherer

et al. 2014

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…IL-6 is mainly secreted from stromal vascular cells [ 46 ]. Elevated IL-6 plasma levels have been described in patients with T2D and especially in those who had features of insulin resistance [ 47 ]. These levels declined in parallel with weight loss in obese individuals undergoing bariatric surgery [ 48 ].…”

Section: Adipokines and Other Molecules That May Induce Insulin Resismentioning

confidence: 99%

State of the art paper Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns

Papaetis¹,

Papakyriakou²,

Panagiotou³

2015

aoms

120

103

View full text Add to dashboard Cite

The prevalence of type 2 diabetes (T2D) is rapidly increasing. This is strongly related to the contemporary lifestyle changes that have resulted in increased rates of overweight individuals and obesity. Central (intra-abdominal) obesity is observed in the majority of patients with T2D. It is associated with insulin resistance, mainly at the level of skeletal muscle, adipose tissue and liver. The discovery of macrophage infiltration in the abdominal adipose tissue and the unbalanced production of adipocyte cytokines (adipokines) was an essential step towards novel research perspectives for a better understanding of the molecular mechanisms governing the development of insulin resistance. Furthermore, in an obese state, the increased cellular uptake of non-esterified fatty acids is exacerbated without any subsequent β-oxidation. This in turn contributes to the accumulation of intermediate lipid metabolites that cause defects in the insulin signaling pathway. This paper examines the possible cellular mechanisms that connect central obesity with defects in the insulin pathway. It discusses the discrepancies observed from studies organized in cell cultures, animal models and humans. Finally, it emphasizes the need for therapeutic strategies in order to achieve weight reduction in overweight and obese patients with T2D.

show abstract

“…Its pathological mechanism is mainly related to the disorder of glucose and lipid metabolism of cardiomyocytes under high glucose environment, and the electrophysiological abnormalities of cardiomyocytes caused by changes in energy metabolism. Hrnciar [35] found that 74.3% of patients with macrovascular lesions of coronary artery disease had insulin resistance. In addition, adipocytes in patients with type 2 diabetes also show insulin resistance, with continuous fat dissolution, elevated free fatty acids and transported to the liver, resulting in increased liver derived very low-density lipoprotein cholesterol, which eventually leads to the aggravation of atherosclerosis [36] .…”

Section: Insulin Resistancementioning

confidence: 99%

Research Progress on the Association between Depression and Coronary Heart Disease and Diabetes

2023

FMSR

View full text Add to dashboard Cite

As one of the important mental diseases, depression is closely related to coronary heart disease and diabetes. Depression belongs to the category of "depression" and "insomnia" in traditional Chinese medicine, among which coronary heart disease and diabetes are manifested in traditional Chinese medicine as depression caused by heartache, depression caused by thirst, disease depression, etc. Related studies have shown that MAPK signaling pathway, NF-κB signaling pathway, inflammatory response, HPA axis dysfunction, neurotrophic reduction, oxidative stress, insulin resistance, intestinal flora dysbiosis, behavioral abnormalities play important roles in the comorbidity pathological mechanism. This article summarizes relevant literature in recent years, exploring the etiology of traditional Chinese medicine and the pathogenesis of Western medicine, in order to provide reference for its clinical treatment.

show abstract

Prevalence of metabolic syndrome, insulin resistance, and microvascular angina pectoris in 500 consecutive patients referred to coronarography

Abstract: Hyperinsulinemia and high prevalence of various symptoms of metabolic syndrome (MS) were found in high percentage of patients with after load precordial pain who were referred to coronarography. Similarly, in several women, MIV-AP was detected and its affiliation to MS suggested.

Cited by 8 publications

References 0 publications

Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet

Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet

State of the art paper Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns

Research Progress on the Association between Depression and Coronary Heart Disease and Diabetes

Contact Info

Product

Resources

About