Prevalence of metabolic syndrome in female and male patients at risk of psychosis

Cordes, Joachim; Bechdolf, Andreas; Engelke, Christina; Kahl, Kai G.; Balijepalli, Chakrapani; Lösch, Christian; Klosterkötter, Joachim; Wagner, Michael; Maier, Wolfgang; Heinz, Andreas; Millas, Walter de; Gäebel, Wolfgang; Winterer, Georg; Janssen, Birgit; Schmidt-Kraepelin, Christian; Schneider, Frank; Lambert, Martin; Juckel, Georg; Wobrock, Thomas; Riedel, Michael; Moebus, Susanne

doi:10.1016/j.schres.2016.09.012

Cited by 36 publications

(30 citation statements)

References 24 publications

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“…In our two FEP cohorts, we found a link between an increase in serum HDL-C and Examining the above relationship (Figure 4), one way of looking at it may be that having higher HDL-C levels per se is associated with a lesser symptom load. In support of this, higher levels of HDL-C have been linked to less transitioning to psychosis in high-risk patients 277 , and a worsening of HDL-C levels has been observed as the illness progresses into chronicity 229 . Figure 4 could also be interpreted this way: increasing HDL-C levels by any means might be beneficial for psychotic symptom relief.…”

Section: What Does the Link Between Serum Hdl-c And Symptom Change Immentioning

confidence: 86%

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Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders

Gjerde

Jørgensen

Steen

et al. 2018

Psychiatry Research: Neuroimaging

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I would like to first and foremost acknowledge the contribution from all study participants for contributing with their time and providing valuable data for our research. I am very grateful to Professor Vidar M. Steen, my main supervisor, for including me in his research group, for allowing me the chance to take my PhD and the time to mature. I am also grateful to Professor Ingrid Melle, my co-supervisor, for her extensive knowledge of clinical areas and statistics. She has, without doubt, challenged me the most, asking critical questions, not letting me settle for anything less than my very best. Also, I would like to thank Silje Skrede and Professor Erik Johnsen, my other two co-supervisors, for their valuable inputs. From the TOP group in Oslo, I would like to extend my deepest gratitude to Professor Ole Andreassen for his time, comments for improving the articles, and in general for sharing his immense knowledge. Words cannot describe how deeply grateful I am for having psychiatrist Ingrid Dieseth and clinical psychologist Carmen Simonsen as collaborators and friends. With their positive attitudes and patience for all sorts of questions, they are truly the ideal combination for anyone venturing in the fields of biological psychiatry and neurocognition. I am also thankful to Professor Ingrid Agartz and postdoc Kjetil Jørgensen for navigating me through the fascinating world of neuroimaging. Kjetil has been like a co-supervisor for me, with his patience, steadiness, and expertise. I have genuinely appreciated our long discussions, even those at 2 o'clock in the night. Furthermore, I would like to thank all previous and present members of the Martens group for practical and social input during my years in the group. From the Statistical Department at Haukeland University Hospital, I also have to thank Professor Geir Egil Eide for introducing me to mixed-effects models and for double-checking the analyses. 7 My sincere thanks to Professor emeritus Knut Wester, as he was the one who first introduced me to research back when I was a medical student, and who encouraged me in perusing this PhD. Over the years he has always been available for both PhD-related discussions, but also for discussing any problems related to life in general. My clinical supervisor, Mildrid Clementsen, from my years as a resident doctor at Sandviken Hospital also deserves a huge thank, as she has been there through all the "ups and downs" in this PhD, giving wisdom and comfort when needed. Nevertheless, the most important and inspirational people in my life are my family. I wish to sincerely thank my husband, Åsmund, for his endless love and support. I am also eternally grateful for all the support and help from my mother, Sarva. This study would never have seen daylight had it not been for my mum and my husband. Finally, I owe my two children, Isak and Ivar the world. They have been there with their smiles, warm hugs,

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Section: What Does the Link Between Serum Hdl-c And Symptom Change Immentioning

confidence: 86%

“…Finally, disturbances related to serum lipids have been exhibited in the early phases of the disorder 120,143,144 . According to two recent meta-analyses, FEP patients with minimal or no exposure to antipsychotics show differences in serum lipid profiles compared to healthy controls 120,145 .…”

Section: Evidence Of Lipid Disturbances In Schizophreniamentioning

confidence: 99%

Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders

Gjerde

Jørgensen

Steen

et al. 2018

Psychiatry Research: Neuroimaging

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show abstract

“…[11][12][13][30][31][32] Previous research also shows that metabolic abnormalities are common in adolescents receiving mental healthcare, but often go unnoticed and untreated. 6,10,13,21 Individuals admitted to generic and secure mental health wards have a wide range of difficulties and non-specific mental health needs, and may or may not be prescribed psychotropic medication. It is therefore important to develop clear guidelines and policies that focus on adolescents in mental healthcare, regardless of their diagnosis or physical health status.…”

Section: Importance Of Monitoringmentioning

confidence: 99%

“…1,2,4 It occurs early, often preceding the onset of illness, thus offering the opportunity to intervene to prevent comorbid conditions. 5,6 Young people with mental health disorders are a vulnerable group requiring additional physical healthcare. 1,7 Adolescent in-patients are particularly at risk, given the ‘obesogenic’ environment.…”

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confidence: 99%

Evaluation of the physical health of adolescent in-patients in generic and secure services: retrospective case-note review

et al. 2019

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Aims and methodTo assess physical health needs of adolescent in-patients by routine monitoring. A retrospective analysis of case notes was conducted on a 6-month intake to generic and secure adolescent mental health units in Greater Manchester, UK.ResultsFifty individuals were admitted (52% female, average age 15.84 years). Diagnoses varied and 66% were prescribed medications before admission. All had a physical health assessment, which identified various physical health risk factors. Average body mass index was 25.99 (range 15.8–44), and increased during in-patient treatment for 84% of individuals who had their body mass recorded more than once. A total of 28% of individuals smoked. Lipids and prolactin levels were elevated across the sample.Clinical implicationsThis evaluation strengthens the argument to optimise physical healthcare for adolescent in-patients and develop physical health interventions, particularly given that we observed elevated lipids and prolactin. Physical health and well-being may not be prioritised when assessing and managing young peoples' mental health, despite their increased vulnerability for comorbid conditions.

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“…The same is probably true for the relationship between schizophrenia and dyslipidemia [in MetS defined as a decreased high density lipoprotein (HDL)-cholesterol and elevated triglycerides] (12). Over 20% of the treatment-naïve (prodromal or first-episode) schizophrenia patients have a lowered HDL-cholesterol level and a glucose dysregulation/insulin resistance (7, 13).…”

Section: Introductionmentioning

confidence: 99%

Changes in Body Fat and Related Biochemical Parameters Associated With Atypical Antipsychotic Drug Treatment in Schizophrenia Patients With or Without Metabolic Syndrome

et al. 2019

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Background: Metabolic syndrome (MetS) is a common problem in schizophrenia patients and associated with increased mortality due to cardiovascular disease. Second-generation antipsychotics (SGAs) play an important role in facilitating MetS.Objective: The study aimed to assess weight changes and alterations of indicators of body fat composition and lipid-glucose metabolism induced by reinitiating atypical antipsychotics in patients with schizophrenia when with or without MetS.Methods: After giving informed consent, newly admitted patients with a clinical diagnosis of schizophrenia (ICD-10: F20) and an age between 18 and 55 years were included. MetS was diagnosed according to International Diabetes Federation (IDF) criteria. At entry and after 6 weeks of treatment, anthropometry and biochemical analysis were carried out. Total and visceral fats were measured with the use of non-invasive bioimpedance analysis and subcutaneous fat with calculation of total adipose tissue with the use of caliperometry. Based on biochemical assessments low density (LDL) and very low-density lipoproteins (VLDL), atherogenic index and Homeostatic Model Assessment of Insulin Resistance (IR-HOMA) were calculated. Statistical analysis was conducted using Wilcoxon signed-rank test, Mann-Whitney U-test, and chi-squared test. Differences were considered statistically significant at p < 0.05.Results: A total of 114 patients (59M/55F) with schizophrenia were examined; they were divided into two groups with (n = 43; 37.7%) and without (n = 71; 62.3%) MetS. After a 6-week SGA treatment, only the total fat fold, waist circumference, triglyceride level, and atherogenic index underwent statistically significant changes in patients with MetS. In those without MetS, statistically significant changes across all fat indicators were noted. Also, a significant increase in blood glucose and HOMA-IR parameters, triglyceride, and VLDL levels and atherogenic index was observed in this group.Discussion: The study illustrates the benefits of estimating both anthropometric and biochemical parameters shortly after (re)installing treatment of schizophrenia in order to minimize the risk of MetS development.

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Prevalence of metabolic syndrome in female and male patients at risk of psychosis

Cited by 36 publications

References 24 publications

Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders

Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders

Evaluation of the physical health of adolescent in-patients in generic and secure services: retrospective case-note review

Changes in Body Fat and Related Biochemical Parameters Associated With Atypical Antipsychotic Drug Treatment in Schizophrenia Patients With or Without Metabolic Syndrome

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