Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based cross-sectional study

Milčić, Danijela; Janković, Slavenka; Vesić, Sonja; Milinković, Marija; Marinković, Jelena; Ćirković, Andja; Janković, Janko

doi:10.1590/abd1806-4841.20175178

Cited by 47 publications

(51 citation statements)

References 43 publications

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“…[159][160][161] Psoriasis has been associated with multiple sclerosis, metabolic syndrome, inflammatory bowel disease, and psychiatric disease, although no studies have reported on the prevalence of SIgAD among individuals with psoriasis. [162][163][164][165] Seven studies have reported the prevalence of psoriasis among individuals with SIgAD, with results varying between 0% and 6.3%, with a weighted average of 2.72%.…”

Section: Psoriasismentioning

confidence: 99%

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Odineal

Gershwin

2019

Clinic Rev Allerg Immunol

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Selective Immunoglobulin A Deficiency (SIgAD) is the most common primary immunodeficiency, defined as an isolated deficiency of IgA (less than 0.07 g/L). Although the majority of people born with IgA deficiency lead normal lives without significant pathology, there is nonetheless a significant association of IgA deficiency with mucosal infection, increased risks of atopic disease, and a higher prevalence of autoimmune disease. To explain these phenomena, we have performed an extensive literature review to define the geoepidemiology of IgA deficiency and particularly the relative risks for developing Systemic Lupus Erythematosus, hyperthyroidism, hypothyroidism, type 1 diabetes mellitus, Crohn's Disease, ulcerative colitis, rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, and vitiligo; these diseases have strong data to support an association. We also note weaker associations with scleroderma, celiac disease, autoimmune hepatitis, immune thrombocytopenic purpura, and autoimmune hemolytic anemia. Minimal if any associations are noted with myasthenia gravis, lichen planus, and multiple sclerosis. Finally, more recent data provide clues on the possible immunologic mechanisms that lead to the association of IgA deficiency and autoimmunity; these lessons are important for understanding the etiology of autoimmune disease. 2 3 Introduction:

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Section: Psoriasismentioning

confidence: 99%

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Odineal

Gershwin

2019

Clinic Rev Allerg Immunol

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“…We could consider that higher levels of serum MK might be a useful clue to distinguish psoriatic patients who may have metabolic syndrome in order to make further work up, since metabolic syndrome generally shows elevated triglyceride concentration. 19,20 We did not find any correlation between serum MK level and PASI. Of note, it has been shown in many studies that PASI is not correlated with metabolic syndrome.…”

Section: Discussionmentioning

confidence: 52%

“…Of note, it has been shown in many studies that PASI is not correlated with metabolic syndrome. [20][21][22][23] New data has recently emerged showing MK has an important function in the steps of inflammation which also functions in the pathogenesis of both psoriasis and metabolic syndrome. 24,25 It is thought that MK might function in inflammation pathways via recruiting inflammatory cells including neutrophils and macrophages by inducing monocyte chemoattractant protein-1 (MCP-1).…”

Section: Discussionmentioning

confidence: 99%

Serum Midkine Levels in Patients with Psoriasis

Purnak¹,

Çakmak²,

Çakır³

et al. 2020

Turkiye Klinikleri J Dermatol

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Midkine (MK) is a multifunctional molecule functioning in the developmental period of the fetus. It was first discovered in embryonic carcinoma cells with increased expression in early stages of differentiation. 1 In adults, MK is expressed in limited sites such as epidermis, kidney, lymphocytes and gut. 2 MK has critical function in development and repair mech-anisms in normal cells as well as tumor growth, invasion and angiogenesis in cancer cells. 3,4 Various studies have shown that tumor prognosis is worse in the patients with higher MK levels. 5-7 Moreover, higher serum MK levels were detected in various inflammatory diseases such as rheumatoid arthritis, inflammatory bowel diseases, atherosclerosis and Turkiye Klinikleri J Dermatol. 2020;30(1):1-5 ABS TRACT Objectives: Midkine is a heparin-binding growth factor which functions in development and repair mechanisms. It also has roles in tumor growth, invasion and angiogenesis in cancer cells. Recently, higher serum midkine levels were detected in inflammatory diseases such as rheumatoid arthritis, inflammatory bowel diseases, atherosclerosis and obesity. In the present study, we aimed to investigate serum midkine levels in patients with psoriasis. We also tried to reveal if there is a relationship between serum midkine levels and psoriasis disease activity. Material and Methods: Forty-five patients with psoriasis and age, sex-matched healthy controls were enrolled in the study. Serum midkine level, complete blood count, fasting serum glucose level, lipid profile (HDL, LDL, triglyceride, cholesterol), CRP (C-reactive protein), serum liver function tests (ALT; AST) and kidney function tests (urea and creatinine) were studied. Psoriasis area severity index (PASI) scores and body mass indexes were calculated for each patient. Results: We found significantly higher serum midkine levels in patients with psoriasis compared to control group. There was no correlation between serum midkine levels and PASI scores. Serum midkine levels were correlated with serum triglyceride levels in patients with psoriasis. Conclusion: This study showed that serum midkine levels were significantly higher in psoriatic patients than controls. As midkine is only correlated with serum triglyceride level and not correlated with PASI, we think serum midkine is not an ideal serum marker for the evaluation of psoriasis activity.ÖZET Amaç: Midkin, büyüme, gelişme ve tamir mekanizmalarında görevli bir büyüme faktörüdür. Ayrıca, kanser hücrelerinde tümör büyümesi, invazyon ve anjiyogenezden sorumludur. Son zamanlarda, romatoid artrit, inflamatuar bağırsak hastalıkları, ateroskleroz ve obezite gibi bircok inflamatuvar hastalıkta yüksek serum midkin seviyeleri tespit edilmiştir. Çalışmamızda, psöriyazisli hastalarda serum midkin seviyesini ve bu seviyelerin hastalık aktivitesi ile ilişkisini belirlemeyi hedefledik. Gereç ve Yöntemler: Psöriyazis tanısı almış 45 hasta ile yaş ve cinsiyet açısından eşleşmiş kontroller çalışmaya dahil edildi. Tüm hasta ve kontrollerde, serum midkin seviyeleri, tam kan...

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“…Charakterystycznym zjawiskiem omawianej dermatozy jest parakeratoza, czyli przyspieszone, niepełne rogowacenie, spowodowane zaburzoną proliferacją i różnicowaniem keratynocytów w warstwie podstawnej skóry. Chorujący na łuszczycę należą do grupy pacjentów o podwyższonym ryzyku wystąpienia zespołu metabolicznego (zespół X), choroby niedokrwiennej serca, miażdżycy tętnic, nadciśnienia tętniczego, dyslipidemii oraz cukrzycy [1,2,3,4,5]. Należy mieć na uwadze, iż łuszczyca jest niezależnym czynnikiem ryzyka choroby niedokrwiennej serca oraz incydentów i śmiertelności na tle sercowo-naczyniowym [6,7].…”

Section: W S T ę Punclassified

“…accelerated, incomplete keratosis caused by abnormal proliferation and differentiation of keratinocytes in the basal layer. Patients with psoriasis belong to the group of patients at an increased risk of metabolic syndrome (dysmetabolic syndrome X), ischemic heart disease, arterial atherosclerosis, hypertension, dyslipidemia and diabetes mellitus [1,2,3,4,5]. It should be noted that psoriasis is an independent risk factor for ischemic heart disease, cardiovascular events and mortality [6,7].…”

Section: Introductionmentioning

confidence: 99%

Concomitance of psoriasis with systemic metabolic diseases – an interdisciplinary problem

Grabarek

Michalska-Bańkowska²,

Krzaczyński

et al. 2019

Ann. Acad. Med. Siles.

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INTRODUCTION: The aim of this study was to assess how often psoriasis co-occurs with diabetes, hypertension, and metabolic syndrome. The intention of the authors is to draw the attention of general practitioners, to the complex clinical picture of psoriasis, the implications of internist diseases, and thus the need to provide patients with interdisciplinary care. MATERIAL AND METHODS: A survey on the prevalence of metabolic systemic comorbidities with psoriasis was performed on a group of 32 patients diagnosed with common psoriasis (20 men and 12 women). The characteristics of the study group are as follows (mean ± standard deviation):

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Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based cross-sectional study

Cited by 47 publications

References 43 publications

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Serum Midkine Levels in Patients with Psoriasis

Concomitance of psoriasis with systemic metabolic diseases – an interdisciplinary problem

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