Prevalence of metabolic syndrome in bipolar disorder: An exploratory study from North India

Grover, Sandeep; Aggarwal, Meenakshi; Chakrabarti, Subho; Dutt, Alakananda; Kulhara, Parmanand; Malhotra, Nidhi; Somaiya, Mansi; Chauhan, Nidhi

doi:10.1016/j.pnpbp.2011.10.013

Cited by 17 publications

(15 citation statements)

References 34 publications

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“…If one of the two blood pressure readings were greater than 130/85 mmHg, we took a third reading 30 min later. We then used the lowest of three readings in the analysis according to a previous study [19]. All subjects underwent venipuncture between 6:00 am and 7:00 am after overnight fasting (~ 12 h), and the blood samples were analyzed on the same day.…”

Section: Methodsmentioning

confidence: 99%

Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder

Chen

Feng³

et al. 2018

BMC Psychiatry

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BackgroundClinical studies have shown that bipolar patients have increased serum uric acid levels. High serum uric acid levels could play a role contributing to high prevalence of metabolic syndrome. Metabolic syndrome is known to increase the risk of developing a number of life threatening diseases including coronary heart disease, hypertension, and type 2 diabetes. This study investigated the association between hyperuricemia and metabolic syndrome and its components in individuals suffering from bipolar disorders.MethodsThis study recruited 318 inpatients suffering from bipolar disorders from Beijing Hui-Long-Guan Hospital in China and 160 healthy subjects from the same region as the controls. We used National Cholesterol Education Program Adult Treatment Panel III Adapted criteria (NCEP ATP-III A) for the diagnosis of metabolic syndrome. Hyperuricemia was determined as serum uric acid level above 420 μmol/L in men and 360 μmol/L in women (N Engl J Med 359(17):1811–1821, 2008).ResultsAmong 318 bipolar patients, there was higher prevalence of metabolic syndrome (42.5%) and hyperuricemia (27.7%) than healthy controls (21.9 and 11.9%). Bipolar patients with metabolic syndrome had increased prevalence of hyperuricemia (OR = 3.0, CI95 [1.7–5.4]). Hypertriglyceridemia and larger waist circumference (WC) were associated with hyperunicemia (OR = 1.8, CI95 [1.1–3.1], OR = 1.9, CI95 [1.1–3.4]). Hyperuricemia was associated with metabolic syndrome in bipolar patients (p < 0.001) and especially with hypertriglyceridemia (OR = 1.9, CI95 [1.1–3.1] and increased WC (OR = 2.1 [1.2–4.0]). Bipolar patients over 50 years of age and hyperuricemia were highly prone to develop metabolic syndrome (OR = 14.0, CI95 [5.0–39.0]).ConclusionsHyperuricemia was highly associated with development of metabolic disorder particularly for aged patients suffering from bipolar disorders. Early prevention of hyperuricemia and metabolic syndrome may lead better life for bipolar patients when they get older.

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Section: Methodsmentioning

confidence: 99%

Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder

Chen

Feng³

et al. 2018

BMC Psychiatry

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“…[ 29 ] Studies which have compared patients of BD with those of other disorders suggest that compared to patients with schizophrenia,[ 30 31 ] those with neurotic disorder, histrionic personality disorder, patients with BD were more likely to be in a relationship. [ 30 ] Demographic data available from various clinic-based studies from India suggest that 64.7%–98%[ 32 33 34 35 ] of patients with BD aged 18–65 years are married. Studies which have compared the demographic profile of adult patients with BD and schizophrenia in general suggest that, compared to patients with schizophrenia, higher proportion of patients with BD are married.…”

Section: Marital Rates and Marital Failure Rates In Patients With Bipmentioning

confidence: 99%

Bipolar affective disorder and its impact on various aspects of marital relationship

2017

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Bipolar disorder (BD) is a severe mental disorder, which not only has negative consequences on the life of the patient, but also affects the immediate family members. As it often starts early in life, patients who get married often suffer from many negative consequences in their marital life due to the illness. This review focuses on studies which have evaluated marital rates, rate of marital failure, divorce, infertility, and procreation among patients with BD. In addition, this review evaluates the existing literature pertaining to marital adjustment, marital satisfaction, sexual dysfunction, and sexual satisfaction among patients with BD and their partners/spouses. Data suggest that very high proportion of patients with BD get married and marital rates are higher for patients with BD, when compared with those suffering from schizophrenia. In terms of divorce rates, studies suggest that patients with BD have higher rates of divorce. In terms of fertility rates, studies suggest that compared to those without the illness, the fertility rates among patients with BD are lower. In terms of marital adjustment, results are mixed with some studies suggesting poorer marital adjustment among patients and their spouses too. In terms of sexual dysfunction, studies suggest the presence of sexual dysfunction among one-third to half of the patients receiving lithium. To conclude, this review suggests that patients with BD experience multiple negative marital and sexual consequences.

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“…This could possibly be due to different cut offs provided by IDF for waist circumference for different countries/ ethnic groups, whereas NCEP ATP–III does not provide such cut-offs, although recently some of the researchers have used adapted/modified NCEP ATP–III criterion for waist circumference. [ 47 49 64 ]…”

Section: Prevalence Of Mets In Bpadmentioning

confidence: 99%

Metabolic Syndrome in Bipolar Disorders

Grover

Malhotra

Chakrabarti

et al. 2012

Indian Journal of Psychological Medicine

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To review the data with respect to prevalence and risk factors of metabolic syndrome (MetS) in bipolar disorder patients. Electronic searches were done in PUBMED, Google Scholar and Science direct. From 2004 to June 2011, 34 articles were found which reported on the prevalence of MetS. The sample size of these studies varied from 15 to 822 patients, and the rates of MetS vary widely from 16.7% to 67% across different studies. None of the sociodemographic variable has emerged as a consistent risk factor for MetS. Among the clinical variables longer duration of illness, bipolar disorder- I, with greater number of lifetime depressive and manic episodes, and with more severe and difficult-to-treat index affective episode, with depression at onset and during acute episodes, lower in severity of mania during the index episode, later age of onset at first manic episode, later age at first treatment for the first treatment for both phases, less healthy diet as rated by patients themselves, absence of physical activity and family history of diabetes mellitus have been reported as clinical risk factors of MetS. Data suggests that metabolic syndrome is fairly prevalent in bipolar disorder patients.

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Prevalence of metabolic syndrome in bipolar disorder: An exploratory study from North India

Cited by 17 publications

References 34 publications

Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder

Association between hyperuricemia and metabolic syndrome in patients suffering from bipolar disorder

Bipolar affective disorder and its impact on various aspects of marital relationship

Metabolic Syndrome in Bipolar Disorders

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