Prevalence of metabolic syndrome in Iran: A meta-analysis of 69 studies

Farmanfarma, Khadijeh Kalan; Kaykhaei, Mahmoud Ali; Adineh, Hosein Ali; Mohammadi, Mehdi; Dabiri, Soroosh; Ansari‐Moghaddam, Alireza

doi:10.1016/j.dsx.2018.11.055

Cited by 113 publications

(100 citation statements)

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“…The average worldwide prevalence of metabolic syndrome is 31% [ 10 ]. In comparison, according to the International Diabetes Federation (IDF) criteria, the prevalence of this disorder in Iranian adults estimate 37.4% [ 11 ] and, based on a meta-analysis of published data during 2000–2016, is higher in some ethnic groups (Bushehr 57.8%) [ 12 ]. Therefore, it is crucial to consider the factors that contribute to metabolic syndrome as a health threat.…”

Section: Introductionmentioning

confidence: 99%

GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

Zahedi

Akbarzadeh

Sedaghati-Khayat

et al. 2021

Diabetol Metab Syndr

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Background Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to evaluate these findings in a cohort study with a large sample size of Iranian adult subjects, to our knowledge for the first time. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly 10 years. Methods Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19–88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants’ association with the incidence of metabolic syndrome in the TCGS cohort study. Results In the current study, we have consistently replicated the association of the GCKR SNPs with higher triglyceride and lower fasting blood sugar levels (p < 0.05) in Iranian adults. The CT genotype of the variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p < 0.05). Conclusions Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

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Section: Introductionmentioning

confidence: 99%

GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

Zahedi

Akbarzadeh

Sedaghati-Khayat

et al. 2021

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…The average worldwide prevalence of the metabolic syndrome is 31% [5]. In comparison, according to the International Diabetes Federation (IDF) criteria, the prevalence of this disorder in Iranian adults estimate 37.4% [6] and, based on a meta-analysis of published data during 2000-2016, is higher in some ethnic groups (Bushehr 57.8%) [7]. Therefore, it is crucial to consider the factors that contribute to metabolic syndrome as a health threat.…”

Section: Introductionmentioning

confidence: 99%

GCKR Common Functional Polymorphisms are Associated with Metabolic Syndrome and its Components: A 10-Year Retrospective Cohort Study in Iranian Adults

Zahedi

Akbarzadeh

Sedaghati-khayat

et al. 2020

Preprint

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Background: Some previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to examine these findings, to our knowledge for the first time, in Iranian adults. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly ten years.Methods: Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19-88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants' association with the incidence of metabolic syndrome in the TCGS cohort study.Results: In the current study, we have consistently replicated the association between the T-allele of GCKR SNPs and higher triglyceride levels and lower fasting blood sugar levels (p<0.05) in the Iranian population. The CT genotype of all three variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p<0.05).Conclusions: Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

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“…For example, the results of a meta-analysis showed that about one-third of Iranians had metabolic syndrome. Besides, the prevalence of this syndrome increases with age (12). According to Sadeghi et al, only due to aging, the CVD burden and DALY in the Iranian population will double in 2025 compared to 2005 (13).…”

Section: Introductionmentioning

confidence: 99%

Association of Cardio-Metabolic Risk Factors and Basic and Instrumental Activities of Daily Living Among Elderly People;Bushehr Elderly Health Program

Khalagi

Ansarifar

Fahimfar

et al. 2020

Preprint

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Background: Iran's population is aging. One of the most common problems in Iranian public health is the high prevalence of cardio-metabolic risk factors. The purpose of this study was to investigate the relationship between cardio-metabolic and demographic risk factors and disability in people 60 years and older in Iran.Methods: Data from the Bushehr Elderly Health (BEH) program was used in the analysis. Demographic characteristics, as well as the history of diabetes and other chronic diseases, and smoking were measured using standardized questionnaires. Anthropometric measurements and laboratory tests were performed under standard conditions. Dependency was determined by the questionnaires of basic activities of daily living (BADL) and instrumental activities of daily living (IADL) using Barthel and Lawton scales respectively. Multiple logistic regression was used in the analysis.Results: Mean (Standard Deviation) of the participants’ age was 69.34 (6.4) years (range: 60 and 96 years), and 48.06% of the participants were men. After adjusting for potential confounders, being older, being female (OR (95%CI): 2.33 (1.89 - 2.86)), having a lower education level, a history of diabetes mellitus (OR: 1.43 (1.17 -1.74)) and past smoking (OR: 1.25 (1.00 - 1.55)), and no physical activity (OR: 1.54 (1.23 - 1.87)) were significantly associated with dependency in IADL. Also, being older and female (OR: 2.38 (1.85 - 3.03)), having a lower education level, no physical activity (OR: 2.17 (1.61 - 2.86)) and low daily intake of calories were associated with dependency in BADL.Conclusion: Age, gender, education level and physical activity are risk factors of the dependency in both of BADL and IADL in the elderly people. Diabetes mellitus and past smoking are risk factors of the dependency in IADL, and low HDL cholesterol and low daily intake of calories are risk factors of the dependency in BADL.

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Prevalence of metabolic syndrome in Iran: A meta-analysis of 69 studies

Cited by 113 publications

References 50 publications

GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

GCKR Common Functional Polymorphisms are Associated with Metabolic Syndrome and its Components: A 10-Year Retrospective Cohort Study in Iranian Adults

Association of Cardio-Metabolic Risk Factors and Basic and Instrumental Activities of Daily Living Among Elderly People;Bushehr Elderly Health Program

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