Prevalence of Mental Disorders and Impact on Quality of Life in Patients With Pulmonary Arterial Hypertension

Olsson, Karen M.; Meltendorf, Tanja; Fuge, Jan; Kamp, Jan C.; Park, Da-Hee; Richter, Manuel J.; Gall, Henning; Ghofrani, Hossein Ardeschir; Ferrari, Pisana; Schmiedel, R; Kulla, Hans-Dieter; Heitland, Ivo; Lepsy, Nicole; Dering, Madelaine-Rachel; Hoeper, Marius M.; Kahl, Kai G.

doi:10.3389/fpsyt.2021.667602

Cited by 36 publications

(48 citation statements)

References 25 publications

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“…Our study also found similar results: 70.09% of patients were judged to have depressive symptoms on the depression score, and 28.22% had moderate to severe depression. The result of the high incidence of depressive symptoms in present study was consistent with a previous study in Beijing, China (11), and in other countries (12). These may be because of the poor prognosis, significant side effects, and activity limitations of patients diagnosed of PAH that may expose patients to higher stressors, leading to the development of depression and anxiety (21).…”

Section: Anxiety and Depression Symptoms Of Patients With Pahsupporting

confidence: 91%

“…For example, a study in Japan reported 64% of candidates had depression and 28% had anxiety (10). A study in Beijing, China, found 66.3% of samples had depression and anxiety (11), while 38.2% of PAH patients reported these symptoms in Germany (12). Some studies also have suggested that patients' anxiety and depression symptoms may further lead to deterioration of physical function (11,13), poor cardiac function (14), poor prognosis (11), worsening quality of life, and increased health-related costs (10).…”

Section: Introductionmentioning

confidence: 99%

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Anxiety and Depression in Patients With Pulmonary Arterial Hypertension in Northwest China: A Cross-Sectional Study

et al. 2022

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ObjectivePulmonary arterial hypertension (PAH) is a rare life-threatening and incurable disease. Although symptoms of depression and anxiety have been widely reported, these traits and associated factors have not been systematically assessed in Northwest China.MethodsA cross-sectional study was conducted between March 2020 and February 2021. 106 PAH patients in Northwest China were evaluated by Self-rating Anxiety Scale (SAS) and the Self Rating Depression Scale (SDS) questionnaire.ResultsOverall, the included patients had particularly high depressive symptoms (70.09%), while anxiety among them was 17.55%. Multivariate linear regression revealed that patients with lower age (p = 0.04), female (p< 0.01), smoking (p< 0.01), WHO functional class III/IV (p< 0.01), higher mean pulmonary hypertension (p< 0.01), lower left ventricular ejection fraction (p< 0.01), and lower 6-min walking distance (p< 0.01) had higher anxiety scores. Patients who lived in rural areas (p = 0.01), smoking (p< 0.01), WHO functional class III/IV (p< 0.01), higher mean pulmonary hypertension (p = 0.04), lower 6-min walking distance (p< 0.01), and college degree or above had higher depression scores (p = 0.02).ConclusionsMental health problems such as depression are common among patients with PAH in Northwest China. Patients' characteristics such as smoking status, WHO functional class, and 6-min walking distance were related to anxiety and depression scores. Thus, early detection of mental health problems such as depression and anxiety should be detected in PAH patients. Meanwhile, interventions against these problems should be used to improve such patients' mental status.

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Section: Anxiety and Depression Symptoms Of Patients With Pahsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Anxiety and Depression in Patients With Pulmonary Arterial Hypertension in Northwest China: A Cross-Sectional Study

et al. 2022

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“…The present study showed a limited impact of the Covid-19 pandemic on anxiety, depression and QoL in patients with PAH. Olsson identified higher prevalence of depression and panic disorder in patients with PAH contributing to impaired QoL ( 18 ). Psychological distress in PAH results from impact on daily life due to physical limitations, unclear prognosis and unemployment ( 28 , 29 ).…”

Section: Discussionmentioning

confidence: 99%

“…This prospective, exploratory observational multicenter study included patients with confirmed PAH of a cohort previously described in the PEPPAH-study ( 18 ), at two participating PH referral centers (Hannover Medical School and University of Giessen, both in Germany). This study was conducted from May 7th, 2020 to August 4th, 2020 by a self-administrated questionnaire.…”

Section: Methodsmentioning

confidence: 99%

“…Frequency of adjustment disorders, anxiety and depression correlate with intensity of symptoms and functional impairment in patients with PAH ( 16 ). Olsson demonstrated a higher prevalence of anxiety and depression disorders in PAH compared to levels in the German general public ( 17 , 18 ). Yogeswaran et al found significant negative impact of the Covid-19 pandemic on access to medical care for patients with suspected pulmonary hypertension (PH) due pandemic related restrictions in Germany ( 19 ).…”

Section: Introductionmentioning

confidence: 97%

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Impact of SARS-CoV-2-Pandemic on Mental Disorders and Quality of Life in Patients With Pulmonary Arterial Hypertension

et al. 2021

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Background/Objective: Covid-19 pandemic may affect mental health and quality of life (QoL) in patients with pulmonary arterial hypertension (PAH). We assessed changes in anxiety and depression, quality of life (QoL) and self-described impact of Covid-19 in patients with PAH during the Covid-19 pandemic.Methods: This study included 152 patients with PAH from two German referral centers. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D) at two different timepoints before and during the Covid-19 pandemic with a median of 232 days between baseline and follow-up. QoL was assessed using EQ-5D and emPHasis-10. Perceived impact of Covid-19 and related regulations and measures were assessed using a set of specific questions and statements.Results: More than two thirds of patients had an unsuspicious HADS-A and HADS-D. Median scores did not differ from baseline for both HADS-A and HADS-D (p = 0.202; p = 0.621). Overall, no significant changes in HADS-A or HADS-D categories from baseline to follow up were observed (p = 0.07; p = 0.13). QoL did not change between baseline and follow-up. The Covid-19 pandemic had little impact on access to medical care and established PAH therapy. Patients were in agreement with governmental measures and regulations and felt sufficiently safe.Conclusion: First waves of Covid-19 pandemic had little impact on anxiety, depression and QoL in patient with PAH. Established PAH therapy and access to medical care were not affected. Further studies on the impact of prolonged duration of the ongoing Covid-19 pandemic are needed.

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Relationship between quality of life, fear of disease progression, and coping styles in patients with pulmonary hypertension: A network analysis

Wang,

Liu,

et al. 2023

Research in Nursing & Health

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A poor quality of life (QoL) in patients with pulmonary hypertension (PH) is often associated with emotional disturbances and the ability to cope. Little is known, however, about the intrinsic links among the QoL, fear of disease progression (FoP), and coping styles in patients with PH. The purpose of this study was to elucidate the relationships among QoL, FoP, and coping styles in patients with PH. We conducted a cross‐sectional survey of 247 patients from a tertiary hospital in Jinan, China and analyzed the relationships using network analysis. Participants completed the World Health Organization's Quality of Life Questionnaire, Fear of Disease Progression Questionnaire and Simple Coping Style Questionnaire during the survey period. The total QoL, positive coping, and negative coping scores were 46.55 ± 10.46, 31.75 ± 6.85, and 18.75 ± 4.66, respectively. The QoL psychological domain had the strongest centrality, deserving more attention than other domains. The coping styles were bridge nodes that connected the whole network, where negative coping and social family FoP, and positive coping and both social and psychological QoL had the strongest positive correlations. There were no significant sex‐based or age‐based differences in the networks. To improve QoL and psychological well‐being in people with PH, healthcare professionals must focus on issues beyond the patient's physical health. Specifically, they should focus on positive coping styles, while developing interventions to promote positive coping and reduce negative coping styles.

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Prevalence of Mental Disorders and Impact on Quality of Life in Patients With Pulmonary Arterial Hypertension

Cited by 36 publications

References 25 publications

Anxiety and Depression in Patients With Pulmonary Arterial Hypertension in Northwest China: A Cross-Sectional Study

Anxiety and Depression in Patients With Pulmonary Arterial Hypertension in Northwest China: A Cross-Sectional Study

Impact of SARS-CoV-2-Pandemic on Mental Disorders and Quality of Life in Patients With Pulmonary Arterial Hypertension

Relationship between quality of life, fear of disease progression, and coping styles in patients with pulmonary hypertension: A network analysis

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