Prevalence of maternal obesity at delivery and association with maternal and neonatal outcomes

Castaneda, Claire; Marsden, Katharine; Maxwell, Timothy; Eyck, Patrick Ten; Kuwaye, Daren; Kenne, Kimberly A.; Merryman, Abbey S.; Steffen, Haley A.; Swartz, Samantha R.; Merrill, Anna E.; Krasowski, Matthew D.; Jackson, J. Brooks; Rysavy, Mary B.

doi:10.1080/14767058.2021.1988563

Cited by 9 publications

(5 citation statements)

References 24 publications

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“…Higher phagocytic affinity is a salient feature of regulatory monocytes/macrophages ( Schulz et al, 2019 ; Jaggi et al, 2020 ); hence this observation supports our proposed argument of regulatory skewing with maternal obesity. Collectively, these findings provide a potential explanation for increased susceptibility to bacterial infections with maternal obesity in both mouse models ( Myles et al, 2013 ) and neonates in the clinic ( Castaneda et al, 2022 ; Yang et al, 2019 ). In line with earlier data from animal studies ( Griffiths et al, 2016 ), we report a poor induction of key genes such as interferon response factors (IRF), co-stimulation molecules, chemokine receptors, and numerous ISG following ex vivo RSV infection.…”

Section: Discussionmentioning

confidence: 84%

Maternal obesity blunts antimicrobial responses in fetal monocytes

Sureshchandra

Doratt

Mendza

et al. 2023

eLife

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Maternal pre-pregnancy (pregravid) obesity is associated with adverse outcomes for both mother and offspring. Amongst the complications for the offspring is increased susceptibility and severity of neonatal infections necessitating admission to the intensive care unit, notably bacterial sepsis and enterocolitis. Previous studies have reported aberrant responses to LPS and polyclonal stimulation by umbilical cord blood monocytes that were mediated by alterations in the epigenome. In this study, we show that pregravid obesity dysregulates umbilical cord blood monocyte responses to bacterial and viral pathogens. Specifically, interferon-stimulated gene expression and inflammatory responses to respiratory syncytial virus (RSV) and E. coli respectively were significantly dampened. Although upstream signaling events were comparable, translocation of the key transcription factor NF-kB and chromatin accessibility at pro-inflammatory gene promoters following TLR stimulation was significantly attenuated. Using a rhesus macaque model of western style diet-induced obesity, we further demonstrate that this defect is detected in fetal peripheral monocytes and tissue-resident macrophages during gestation. Collectively, these data indicate that maternal obesity alters metabolic, signaling, and epigenetic profiles of fetal monocytes leading to a state of immune paralysis during late gestation and at birth.

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Section: Discussionmentioning

confidence: 84%

Maternal obesity blunts antimicrobial responses in fetal monocytes

Sureshchandra

Doratt

Mendza

et al. 2023

eLife

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“…However, following differentiation, obese UCB monocyte-derived macrophages displayed an unbalanced response to M1 and M2 polarizing stimuli ( 30 ). These defects provide a potential explanation for increased susceptibility to bacterial infections in neonates born to mothers with obesity ( 51, 52 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of pregravid obesity on anti-microbial fetal monocyte response

Sureshchandra

Doratt

Mendoza

et al. 2022

Preprint

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Maternal pre-pregnancy (pregravid) obesity is associated with adverse outcomes for both mother and offspring. Amongst the complications for the offspring is increased susceptibility and severity of neonatal infections necessitating admission to the intensive care unit, notably bacterial sepsis and enterocolitis. Previous studies have reported aberrant responses to LPS and polyclonal stimulation by umbilical cord blood monocytes that were mediated by alterations in the epigenome. In this study, we show that pregravid obesity dysregulates umbilical cord blood monocyte responses to bacterial and viral pathogens. Specifically, interferon-stimulated gene expression and inflammatory responses to E. coli and respiratory syncytial virus (RSV) were significantly dampened. Although upstream signaling events were comparable, translocation of the key transcription factor NFkB and chromatin accessibility at pro-inflammatory gene promoters following TLR stimulation was significantly attenuated. Using a rhesus macaque model of western style diet induced obesity, we further demonstrate that this defect is detected in fetal peripheral monocytes and tissue-resident macrophages during gestation. Collectively, these data indicate that maternal obesity and high-fat diet present metabolic, signaling, and epigenetic impediments to pathogen recognition in fetal innate immune cells that result in a state of immune paralysis during gestation and at birth.

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“…[12,13,14] The COVID-19 pandemic has introduced additional challenges, affecting health systems and potentially altering obesity rates in pregnant women. [15] Understanding how the pandemic has affected the prevalence and management of obesity in this group is essential to tailor clinical interventions to meet the changing needs of these women. [16] Therefore, the aim of this study is to analyse the maternal and neonatal consequences and morbidities associated with maternal obesity in the community of Cantabria, northern Spain, during the postpandemic period (2021)(2022).…”

Section: Introductionmentioning

confidence: 99%

Maternal-Foetal Complications in Pregnant Women with Obesity: a predictive model

Díez-Ibarbia,

Odriozola-Feu,

Díez-Paz

et al. 2024

Preprint

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Background Obesity is a recognised global epidemic with serious consequences, including increased risk of morbidity and reduced life expectancy. It is a chronic, multifactorial disease defined by a Body Mass Index ≥ 30 kg/m2. It also imposes a significant economic burden on individuals, families and countries. During pregnancy, maternal obesity is a significant risk factor, making pregnancy a vulnerable period for obese women, potentially worsening its course and having adverse effects on both mother and foetus. In addition, the offspring of obese pregnant women are at increased risk of obesity in childhood and adulthood. Therefore, the aim of this study was to describe the maternal and neonatal consequences and morbidity associated with maternal obesity in pregnant women in the community of Cantabria, northern Spain, in the post-pandemic era. Methods This was achieved through a retrospective observational descriptive study of pregnant women who gave birth at the Marqués de Valdecilla University Hospital in Cantabria during the years 2021 and 2022. STROBE's COREQ recommendations were followed. Results No significant differences were found in the incidence of diseases during pregnancy and postpartum between 2021 and 2022. However, a significant difference was found in the need for Neonatal Intensive Care Unit admission, with a higher proportion of newborns admitted to the Neonatal Intensive Care Unit in 2022. The classification model suggests that diseases during pregnancy, especially Hypertension arterial, complications during labor (with hemorrhage as the main one), and the reason for cesarean section, Risk of Foetal Well-being Loss, are significant predictors of the type of delivery. A significant increase in the frequency of all treatments was observed during the puerperium compared to gestation. Conclusions Obesity increases the risk of presenting diseases and complications during pregnancy, childbirth and neonatal risks. Therefore the pregnancy is a conflict for public health because it increases obstetric.

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Prevalence of maternal obesity at delivery and association with maternal and neonatal outcomes

Cited by 9 publications

References 24 publications

Maternal obesity blunts antimicrobial responses in fetal monocytes

Maternal obesity blunts antimicrobial responses in fetal monocytes

Impact of pregravid obesity on anti-microbial fetal monocyte response

Maternal-Foetal Complications in Pregnant Women with Obesity: a predictive model

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