Prevalence of malocclusions in children with microcephaly associated with the Zika virus

Amaral, Beatriz Aguiar do; Gomes, Patrícia Nóbrega; Azevedo, Isabelita Duarte; Galvão, Hébel Cavalcanti; Oliveira, Ângelo Giuseppe Roncalli da Costa; Rabelo, Sergei Godeiro Fernandes

doi:10.1016/j.ajodo.2020.03.025

Cited by 3 publications

(11 citation statements)

References 32 publications

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“…Thirteen studies reported the criteria used for the diagnosis of microcephaly, 10,13–16,18,19–22,31–34 10 studies performed or had access to the result of the test used to detect ZIKV 10,16–20,22,31,33,34 and, 12 studies diagnosed the CZS by combining clinical, radiographic, and serological findings 10,15–20,22,31–34 (Appendix 3). Seven studies were funded by a government or university grant, 10,12,15,16,19,20,34 and 13 declared no conflicts of interest 10,13,14,17,18,20,21,31–35 …”

Section: Resultsmentioning

confidence: 99%

“…Seven studies reported data related to prematurity 10,12,14,18,19,31,32 and four related to birth weight. 10,14,19,32 Thirteen studies reported the criteria used for the diagnosis of microcephaly, 10,[13][14][15][16]18,[19][20][21][22][31][32][33][34] 10 studies performed or had access to the result of the test used to detect ZIKV 10,[16][17][18][19][20]22,31,33,34 and, 12 studies diagnosed the CZS by combining clinical, radiographic, and serological findings 10,[15][16][17][18][19][20]22,[31][32][33][34] (Appendix 3). Seven studies were funded by a government or university grant, 10,…”

Section: F I G U R E 1 Study Selection Abbreviation: Zikv Zika Virusmentioning

confidence: 99%

“…Seven studies were funded by a government or university grant, 10,12,15,16,19,20,34 and 13 declared no conflicts of interest. 10,13,14,17,18,20,21,[31][32][33][34][35] The major methodological issues of the studies were related to confounding factors (n = 7), 10,[13][14][15]19,21,33 and strategies to deal with them (n = 16). 10,12,14,15,[17][18][19][20][21][22]31,32,[35][36][37][38] The study subjects and the setting were not clearly described in nine studies, 10,12,14,17,21,22,33,35,…”

Section: F I G U R E 1 Study Selection Abbreviation: Zikv Zika Virusmentioning

confidence: 99%

“…Its known that there are differences in the oral health of children with CZS‐associated microcephaly and normotypic children. However, the literature is still scarce and it is not clear whether there is a pattern related to these oral findings, similarly to the medical findings already identified and scientifically supported 13,15,18,33 . Therefore, it is necessary to gather the reported findings of the oral alterations of these children in order to provide treatments as early as possible and to avoid other complications.…”

Section: Introductionmentioning

confidence: 95%

“…However, the literature is still scarce and it is not clear whether there is a pattern related to these oral findings, similarly to the medical findings already identified and scientifically supported. 13,15,18,33 Therefore, it is necessary to gather the reported findings of the oral alterations of these children in order to provide treatments as early as possible and to avoid other complications. This systematic review and meta-analysis aims to: (1) synthesize the oral alterations occurring in children born with CZS-associated microcephaly; and (2) compare the oral alterations in children born with CZS-associated microcephaly compared to a normotypic control children.…”

mentioning

confidence: 99%

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Oral alterations in children with microcephaly associated to congenital Zika syndrome: A systematic review and meta‐analyses

Silva

Hermont

Magnani

et al. 2022

Special Care in Dentistry

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AIMS To synthesize the oral alterations observed in children with microcephaly associated with congenital Zika virus syndrome (CZS), and to compare the oral alterations of these children to a normotypic healthy controls. METHODS AND RESULTS A search was performed in six electronic databases. Observational studies published that reported oral alterations in children with CZS were selected. Two authors independently extracted data, assessed study quality, using the Joanna Briggs Institute Critical Appraisal Checklist tools, and the certainty of evidence, using Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Twenty‐one studies were included in this systematic review and meta‐analysis. The pooled crude occurrence showed 88% of increased salivation (95%CI: 82%–94%), 83% of biofilm (95%CI: 75%–91%), and 73% of bruxism (95%CI: 52%–95%). Compared to normotypic controls, children with CZS‐associated microcephaly had a higher chance to have difficulty in lip sealing (OR: 18.28; 95%CI: 1.42–235.91), inadequate lingual posture at rest (OR: 13.57; 95%CI: 4.24–43.44), and delayed eruption (OR: 12.92; 95%CI: 3.42–48.78), with very low certainty. CONCLUSION There are several oral alterations found among children with CZS‐associated microcephaly. They are more prone to present some of these alterations, such as difficulty in lip sealing, although with very low certainty of evidence.

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Section: Resultsmentioning

confidence: 99%

Section: F I G U R E 1 Study Selection Abbreviation: Zikv Zika Virusmentioning

confidence: 99%

Section: F I G U R E 1 Study Selection Abbreviation: Zikv Zika Virusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

mentioning

confidence: 99%

See 3 more Smart Citations

Oral alterations in children with microcephaly associated to congenital Zika syndrome: A systematic review and meta‐analyses

Silva

Hermont

Magnani

et al. 2022

Special Care in Dentistry

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Craniofacial and dental features in children aged 3–5 years with congenital Zika syndrome

et al. 2023

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Objective Zika virus infection has been associated to congenital zika syndrome (CZS) in newborns and is characterized by microcephaly, central/axial motor and sensory dysfunction, dysphagia among other previously described severe health complications. CZS is usually diagnosed postpartum by evident/apparent neural development problems. Although there are some reports of craniofacial/dentition development in CZS, several clinical oral aspects are still unknown. This study describes some structural and functional characteristics of facial and cranial growth and deciduous dentition in CZS-affected children. Material and methods Some cranial, facial and dental characteristics were determined in 14 children with CZS aged 3–5 years and compared them against 12 apparently healthy children paired by age and gender. Results Fourteen CZS cases presented microcephaly, maxillary prognathism, altered facial thirds, asymmetric pupillary line, bruxism (p = 0.006), deep and anterior open bite and distal step decidual molar relationship (p = 0.031). CZS children cannot feed by themselves and most cannot walk and have not develop coordinated and intelligible language according to their chronological age. In contrast, controls presented normal skull features, have autonomous locomotion skills, speak intelligible language, feed by themselves, presented a harmonic intermaxillary relationship and have symmetrical facial thirds. Conclusion Microcephaly, dysphagia, bruxism, mandibular retrognathia, altered facial proportions and malocclusion are the main craniofacial and oral features at CZS. Clinical relevance The complications of CZS including those related with the face and the oral cavity are still being identified. This study revealed some cranial, facial and oral features in children affected by CSZ. Interdisciplinary rehabilitation protocols must address these syndromic features that could improve children and parents living conditions.

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Microcephaly as a risk factor for dental alterations: A case‐control study

et al. 2022

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Objective This study aimed to assess whether microcephaly is a risk factor for alterations in the chronology and sequence of tooth eruption and for developmental defects of enamel. Matherials and Methods In this case‐control study, 81 children aged 30–36 months, including 40 normoreactive children and 41 with microcephaly, were submitted to oral clinical examination to determine the frequency of alterations in the chronology and sequence of tooth eruption and developmental enamel defects. The sample was matched for sex and age (1:1) and allocated to the case (presence of dental alterations) and control (absence of dental alterations) groups. Gestational age, birthweight and socioeconomic characteristics were also analyzed. Chi‐square test and Fisher's exact test were applied (α = 0.05). Results Microcephaly was significantly associated with delayed tooth eruption, alterations in the sequence of tooth eruption, and defects in dental enamel (p < 0.001). Low birthweight also showed a significant association with this alterations (p < 0.005) and prematurity was associated with defects in enamel development (p < 0.005). Conclusion Microcephaly is a risk factor for alterations in the tooth eruption process and enamel formation in primary teeth.

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Prevalence of malocclusions in children with microcephaly associated with the Zika virus

Cited by 3 publications

References 32 publications

Oral alterations in children with microcephaly associated to congenital Zika syndrome: A systematic review and meta‐analyses

Oral alterations in children with microcephaly associated to congenital Zika syndrome: A systematic review and meta‐analyses

Craniofacial and dental features in children aged 3–5 years with congenital Zika syndrome

Microcephaly as a risk factor for dental alterations: A case‐control study

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