Prevalence of malignancy in multinodular goiter and solitary thyroid nodule: a histopathological audit

Palo, Seetu; Mishra, Debadutta

doi:10.18203/2320-6012.ijrms20161807

Cited by 6 publications

(9 citation statements)

References 5 publications

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“…Overall occurrence of thyroid cancer in this study group was high (33.9%) compared to similar studies on the subject. [6][7][8] This partly relates to pooling of suspicious and malignant thyroid lesions in our referral center but also to low incidence of endemic goiter in our country as a result of use of iodized salt. 14 Male gender was identified as a risk factor for thyroid cancer.…”

Section: Discussionmentioning

confidence: 96%

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The risk of thyroid carcinoma in multinodular goiter compared to solitary thyroid nodules: A retrospective analysis of 600 patients

Ajarma

Al-Faouri

Ruhaibeh

et al. 2020

Medical Journal Armed Forces India

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Background: It is generally believed that multinodular goiter (MNG) is associated with a lower risk of malignancy compared to solitary thyroid nodules (STN). This will be the null hypothesis in this retrospective study and we aim to prove or reject it.Methods: Medical files and histopathology reports of 600 patients who underwent thyroidectomy over 4-year period were reviewed. Data including patient' age, gender, presentation, ultrasonography, FNAC, surgical procedures, final histopathologic diagnosis and stage of malignant tumors were collected and analyzed. The primary end point was assessment of risk of thyroid carcinoma in patients with MNG compared to those with STN. Secondary endpoints included demographic differences and prognosis.Results: There were 459 females (76.5%). Mean age was 44.3 AE 14.5 years (range 14-85). After exclusion of 33 patients, 224 (39.5%) had STN and 343 (60.5%) had MNG. The prevalence of thyroid cancer was 41.1% (92/224) in STN compared to 29.2% (100/343) in MNG (Chi-Square = 8.593, p < 0.01). However, on multiple logistic regression analysis this correlation was found insignificant ( p = 0.640). Only male gender ( p = <0.000005) and preoperative impression of malignancy ( p = 0.000082) were significantly associated with thyroid carcinoma.

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Section: Discussionmentioning

confidence: 96%

“…5 It is generally believed that multinodular goiter (MNG) is associated with lower risk of malignancy compared to STN. [5][6][7][8] This will be the null hypothesis of this retrospective study which was designed to prove or reject it.…”

Section: Introductionmentioning

confidence: 99%

The risk of thyroid carcinoma in multinodular goiter compared to solitary thyroid nodules: A retrospective analysis of 600 patients

Ajarma

Al-Faouri

Ruhaibeh

et al. 2020

Medical Journal Armed Forces India

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“…3 However, in recent past, various studies have reported a rising incidence of malignancy even in multinodular goiter. 4 Differentiated thyroid cancer, which includes papillary and follicular cancer, comprises the vast majority (>90%) of all thyroid cancers. 1 Papillary thyroid carcinoma (PTC) is the commonest thyroid cancer accounting approximately 85% of all thyroid cancers.…”

Section: Original Articlementioning

confidence: 99%

Diagnostic utility of trophoblastic cell surface antigen 2 immunohistochemical expression in papillary thyroid carcinoma

2018

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Background: Although nuclear criteria are considered to be characteristic for papillary thyroid carcinoma, some cases do raise controversy as being papillary thyroid carcinoma or non-papillary thyroid carcinoma due to unclear diagnostic nuclear features. Immunohistochemical markers can help in identifying PTC. Trophoblastic cell surface antigen 2 (TROP-2) is a novel marker that is recently applied on thyroid. The aim of this study was to evaluate TROP-2 expression and diagnostic utility in PTC compared to other thyroid nodules with follicular pattern on tissue specimens and cell block sections. Materials and Methods: This retrospective study was carried out at National Cancer Institute, Cairo University between January 2010 and January 2015. Immunohistochemical evaluation of TROP-2 was applied on archival 110 surgically excised and 66 cytological cell blocks of PTC and other follicular thyroid nodules. Membranous staining, with or without cytoplasm, was considered positive.Results: Among excised specimens, 85.1% of PTC demonstrated TROP-2 staining. The majority revealed diffuse staining. No significant staining difference was reported between studied classic and non classic variants. TROP-2 sensitivity and were 85.1% and 94.4%. Among cytological materials, all PTC were positive except two (false negative) and only two follicular adenomas were positive (false positive). TROP-2 sensitivity and specificity were 93.8% and 94.1%. None of nodular hyperplasia or adjacent normal thyroid tissues showed TROP-2 immunoreactivity either on histopathological or cytological sections.Conclusion: TROP-2 positivity was significantly higher in PTC compared to all other studied non PTC lesion in both surgical pathology specimens and cytological materials. No reported significant staining difference among studied PTC variant.

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“…Overall thyroid cancer incidence in our study was high (25%) compared to similar studies on the subject [15][16][17][18]. This partly due to our selecting patients With suspicious and malignant thyroid lesions and also pooling more case as our hospital only referral hospital at that region that provide free service also use of diagnostic imaging and fine-needle aspiration biopsy, which has led to enhanced detection and diagnosis of subclinical nodules also early diagnosis of low-risk lesions [19,20].…”

Section: Surgical Proceduresmentioning

confidence: 58%

“…Thyroid cancer can occur at any age, but the risk peaks earlier for women (who are most often in their 20s or 30s when diagnosed) Mean age of females in this study was 36.21 than for men (who are usually in their 40s) Mean age of males in this study was 39.6 ± 15.6 and this may have contributed to our findings. Some studies found the malignancy is more in solitary thyroid nodules (STN) compared to multinodular goiter [12,13,[15][16][17]24].…”

Section: Surgical Proceduresmentioning

confidence: 99%

The Risk of Thyroid Carcinoma in Multinodular Goiter Compared to Solitary Thyroid Nodules: A Prospective Analysis of 207 Patients

Nasr¹,

Mohamed²,

Sultan³

et al. 2021

J Surgical Endocrinol

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Thyroid nodules are common. Prevalence and incidence increases with age. Palpable Thyroid nodules are found in 5% of persons aged an average of 60 years. With the use of imaging techniques, particularly ultrasound, the chance of detection of thyroid nodules has increased many folds about 20%-60% [1]. Thyroid nodules are more common in women than in men[2]. However, the reported incidence of thyroid cancer in general population is low, being only about 1%. Thyroid cancers occur in approximately 5-15% of all thyroid nodules indepen-

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Prevalence of malignancy in multinodular goiter and solitary thyroid nodule: a histopathological audit

Cited by 6 publications

References 5 publications

The risk of thyroid carcinoma in multinodular goiter compared to solitary thyroid nodules: A retrospective analysis of 600 patients

The risk of thyroid carcinoma in multinodular goiter compared to solitary thyroid nodules: A retrospective analysis of 600 patients

Diagnostic utility of trophoblastic cell surface antigen 2 immunohistochemical expression in papillary thyroid carcinoma

The Risk of Thyroid Carcinoma in Multinodular Goiter Compared to Solitary Thyroid Nodules: A Prospective Analysis of 207 Patients

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