Prevalence of &lt;i&gt;Helicobacter pylori&lt;/i&gt; and endoscopic findings in HIV seropositive patients with Upper gastrointestinal tract symptoms at Kenyatta National Hospital, Nairobi

AliMohamed, F; Gn, Lule; Nyong'o, A; Bwayo, Job; Rana, F.

doi:10.4314/eamj.v79i5.8858

Cited by 29 publications

(43 citation statements)

References 11 publications

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“…A study around the same period as this study found H pylori positivity in 69% of patients with dyspepsia using the rapid urease test [13] . A previous study in the same setting found a rate of up to 73% and 85% among dyspeptic patients with and without HIV respectively [14] . Our high pickup rate of H pylori gives credence to histology as a sensitive method for diagnosing the bacterium, with the added advantage of enabling morphological assessment of the mucosa.…”

Section: Discussionmentioning

confidence: 82%

Histopathological profile of gastritis in adult patients seen at a referral hospital in Kenya

Kalebi

Rana²,

Mwanda³

et al. 2007

WJG

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AIM:To conduct a detailed histological study of gastritis in adult patients attending an endoscopy clinic at a Kenyan teaching and referral hospital. METHODS:Biopsy specimens from consecutive patients were examined and graded according to the Updated Sydney System for H pylori infection, chronic inflammation, neutrophil activity, glandular atrophy and intestinal metaplasia. Also documented were gastric tissue eosinophil counts and presence of lymphoid follicles. RESULTS:The rate of the graded variables, in the antrum and corpus respectively, were as follows: H pylori infection (91%, 86%), chronic inflammation (98%, 93%), neutrophil activity (91%, 86%), glandular atrophy (57%, 15%) and intestinal metaplasia (11%, 2%). Lymphoid follicles were noted in 11% of cases. Duodenal and gastric ulcers were documented in 32% and 2% respectively. The mean eosinophil count was 5.9 ± 0.74 eosinophils/ HPF and 9.58 ± 0.93 eosinophils/HPF in the corpus and antrum respectively. Significant association was found between the degree of H pylori colonisation with chronic inflammation, neutrophil activity and antral glandular atrophy. Biopsies from the antrum and corpus showed significant histopathological discordance for all the graded variables. H pylori negative cases were associated with recent antibiotic use. CONCLUSION:The study reaffirms that H pylori is the chief cause of gastritis in this environment. The majority of patients show a moderate to high degree of inflammation but a low degree of glandular atrophy and intestinal metaplasia. The study shows that interrelationships between the histological variables in this African population are similar to those found in other populations worldwide including non-African populations.

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Section: Discussionmentioning

confidence: 82%

Histopathological profile of gastritis in adult patients seen at a referral hospital in Kenya

Kalebi

Rana²,

Mwanda³

et al. 2007

WJG

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show abstract

“…Previous reports (26)(27)28) seem to have underestimated the prevalence of H. pylori infection in HIV-positive patients. Marano et al (13) concluded that in HIV-infected patients with histologic chronic active gastritis, H. pylori is found at a much lower frequency than in HIV-negative patients, and they added that impaired acid secretion in AIDS may reduce the colonization of gastric mucosa by the bacteria.…”

Section: Discussionmentioning

confidence: 85%

“…Adults with HIV infection and/or a low CD4 count would then lose this mechanism by which H. pylori colonization is sustained, and infection intensity would diminish. Low CD4 counts are apparently associated with low-grade H. pylori infection (20,21,26,27).…”

Section: Discussionmentioning

confidence: 99%

Coinfection: Helicobacter pylori/Human Immunodeficiency Virus

et al. 2004

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To compare H. pylori infection prevalence and gastric mucosa damage in HIV-infected and non-HIV-infected patients, gastric biopsies were systematically taken in 209 individuals who underwent upper Gl endoscopy (102 HIV-infected and 107 non-HIV-infected). H. pylori was found in 42 (41.1%) HIV-infected patients and in 53 (49.5%) non-HIV patients (P = 0.22, chi2 = 1.47, NS). In HIV-positive patients infected with H. pylori the mean CD4 count was higher than in HIV-positive patients without H. pylori (364 and 228 cells/mm3, respectively; P = 0.0001). H. pylori gastritis was more severe in the HIV-positive group (chi2 = 15.02, P = 0.0001). The frequency of H. pylori in gastric mucosa in HIV-infected and non-HIV patients was similar. HIV-infected patients with H. pylori had a higher mean CD4 count than HIV-infected individuals without H. pylori. Gastric lesions associated with H. pylori were more severe in the HIV-positive population.

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“…We recommend investigation for gastroesophageal reflux disease and the use of proton-pump inhibitor therapy in all pediatric cases of CMV esophagitis. The role of esophageal candidiasis in facilitating the inflammation underlying CMV reactivation is not clear, although it has been reported in 10% of biopsied children, and up to 50% of adults with HIV esophagitis [49,50]. The single case of H. pylori in our patients with upper GIT disease would suggest that it is not an important comorbid pathogen.…”

Section: Treatmentmentioning

confidence: 83%

Surgical manifestations of gastrointestinal cytomegalovirus infection in children: Clinical audit and literature review

Arnold

Itzikowitz

Young

et al. 2015

Journal of Pediatric Surgery

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Prevalence of <i>Helicobacter pylori</i> and endoscopic findings in HIV seropositive patients with Upper gastrointestinal tract symptoms at Kenyatta National Hospital, Nairobi

Cited by 29 publications

References 11 publications

Histopathological profile of gastritis in adult patients seen at a referral hospital in Kenya

Histopathological profile of gastritis in adult patients seen at a referral hospital in Kenya

Coinfection: Helicobacter pylori/Human Immunodeficiency Virus

Surgical manifestations of gastrointestinal cytomegalovirus infection in children: Clinical audit and literature review

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