Prevalence of &lt;i&gt;Clonorchis sinensis&lt;/i&gt; Infection among Residents along 5 Major Rivers in the Republic of Korea

Jeong, Yoong Ki; Shin, Hee Eun; Lee, Sang Eun; Cheun, Hyeng-Il; Ju, Jung‐Won; Kim, Jung Yeon; Park, Mi Yeoun; Cho, Dae Won

doi:10.3347/kjp.2016.54.2.215

Cited by 53 publications

(60 citation statements)

References 11 publications

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“…Fish species (No. of fish) examined were Acanthogobius flavimanus (23) Konosirus punctatus (12), Mugil cephalus (13), Carassius auratus (10), Acanthogobius lactipes (7), Cyprinus carpio (2), Tribolodon hakonensis (9), Favonigobius gymnauchen (9), Tridentiger brevispinis (4), Tridentiger trigonocephalus (2), Silurus asotus (1). A total of 113 fishes (9 spp.)…”

Section: Fishes Examined By the Coastal Lakesmentioning

confidence: 99%

“…Fish species (No. of fish) examined were A. flavimanus (16), T. hakonensis (12), T. brevispinis (10), G. castaneus (10), A. lactipes (9), C. auratus (7), K. punctatus (5), M. cephalus (3), C. haematocheilus (2). A total of 155 fishes (11 spp.)…”

Section: Fishes Examined By the Coastal Lakesmentioning

confidence: 99%

“…Nowadays, infections with fishborne zoonotic trematodes (FZT) including clonorchiasis is to be the most important parasitic diseases in the Republic of Korea (Korea) [4][5][6][7]. A team of Korean CDCP (Centers for Disease Control and Prevention) has performed the control project for zoonotic trematodiases in the adjacent residents of 5 major rivers, i.e., Nakdong-gang (gang means river), Seomjin-gang, Geum-gang, Yeongsangang and Han-gang, in Korea [6,7]. The team also participated in the surveys on the infection status of infective stage (metacercariae: infection sources) of ZT in fishes from water systems of major rivers in Korea [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Infection Status with Digenetic Trematode Metacercariae in Fishes from Coastal Lakes in Gangwon-do, Republic of Korea

Sohn

Cho

et al. 2019

Korean J Parasitol

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The infection status of digenetic trematode metacercariae (DTM) was investigated in fishes from coastal lakes in Gangwon-do, the Republic of Korea (Korea). All fishes collected in 5 lakes were examined with the artificial digestion method. More than 10 species, i.e., Metagonimus spp., Pygidiopsis summa, Centrocestus armatus, Metorchis orientalis, M. taiwanensis, Clinostomum complanatum, Echinostoma spp., Stictodora spp., Diplostomum sp. and Diplostomid No. 1. by Morita (1960), of DTM were detected in fishes from 5 coastal lakes in Gangwon-do. Metagonimus spp. metacercariae were found in 52 (41.3%) out of 126 sea rundace, Tribolodon hakonensis, from 5 lakes, and their density was 14.6 per fish infected. P. summa metacercariae were detected in 48 (84.2%) out of 57 mullets from 5 lakes, and their density was 316 per fish infected. C. armatus metacercariae were detected in 7 (14.6%) T. hakonensis and 3 (15.0%) Tridentiger brevispinis from Hyang-ho, and 5 (19.2%) Acanthogobius flavimanus from Gyeongpo-ho. Stictodora spp. metacercariae were found in 4 fish species, i.e., Tridentiger obscurus, Tridentiger trigonocephalus, Chelon haematocheilus, and Acanthogobius lactipes, from Gyeongpo-ho. Total 15 C. complanatum metacercariae were detected in 2 (9.1%) crucian carp, Carassius auratus, from Songji-ho. M. taiwanensis metacercariae were found in T. hakonensis from Hyang-ho and Gyeongpo-ho and in Pseudorasbora parva from Gyeongpo-ho. Total 11 M. orientalis metacercariae were detected in 3 (6.3%) T. hakonensis from Hyang-ho. From the above results, it was confirmed that various species of DTM are infected in fishes from coastal lakes in Gangwon-do, Korea.

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Section: Fishes Examined By the Coastal Lakesmentioning

confidence: 99%

Section: Fishes Examined By the Coastal Lakesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Infection Status with Digenetic Trematode Metacercariae in Fishes from Coastal Lakes in Gangwon-do, Republic of Korea

Sohn

Cho

et al. 2019

Korean J Parasitol

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“…2 The egg-positive rates in the residents of five major rivers were highest in Nakdong-gang (11.7%) followed by Seomjin-gang (9.9%), Geum-gang (6.5%), Yeongsan-gang (3.1%), and Han-gang (1.0%) in 2012. 3 Adult worms of C. sinensis can survive for a period of 20-25 years in the bile ducts, causing clonorchiasis in humans which can result in biliary stones, biliary inflammation, bile duct obstruction, liver cirrhosis, cholangiocarcinoma, and hepatic carcinoma. 4 fish, and present with the biliary symptoms.…”

Section: Introductionmentioning

confidence: 99%

Clonorchis sinensis Infection Presenting as Acute Cholangitis and Acute Cholecystitis

Yang¹,

Choi²,

Ryu³

et al. 2019

Korean J Pancreas Biliary Tract

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A 59-year-old woman presented with abdominal pain. Abdominal computerized tomography was suggestive of biliary stones. During endoscopic retrograde cholangiopancreatography, adult worms resembling Clonorchis sinen sis (C. sinensis) were drained. Eggs were detected in stool using the formalin-ether concentration method and C. sinensis-specific antibody was detected in the serum. A diagnosis of C. sinensis infection was made. The symptoms of the patient gradually resolved after treatment with anti-parasite medication. The patient lived in a non-endemic region for C. sinensis infection and had no history of intake of raw or undercooked freshwater fishes. South Korea is one of the endemic countries for C. sinensis infection and people can be infected via indirect routes of transmission such as cooking utensils. Therefore, the possibility of C. sinensis infection should be considered in patients presenting with biliary diseases in South Korea. We describe the clinical findings of this case with a review of literature.

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“…In South Korea, most parasites, including soil‐transmitted parasites as well as those causing filariasis, are highly controlled, but C. sinensis has remained prevalent because of the common practice of eating raw freshwater fish . In fact, in a 2008 case‐control study in Korea, radiological evidence of C. sinensis and recent consumption of raw freshwater fish were significantly correlated with gallstone formation .…”

Section: Introductionmentioning

confidence: 99%

A 21.6 kDa tegumental protein of Clonorchis sinensis induces a Th1/Th2 mixed immune response in mice

Chung

Kim

Lee

et al. 2018

Immunity Inflam & Disease

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Introduction Clonorchis sinensis is a major parasite affecting the Korea population. Despite the high infection rate and pathogenicity, very few studies have been conducted to investigate the immune responses against the proteins of C. sinensis.MethodsIn this study, in vitro immune response induced by a recombinant 21.6 kDa tegumental protein derived from C. sinensis (rCsTegu21.6) was confirmed in murine dendritic cells and T cells. For the in vivo analysis, each mouse was immunized three times. Total serum IgG and T cell cytokine production were determined by ELISA, while T cell proliferation was detected by a WST (Water‐Soluble Tetrazolium salt)‐1 assay.ResultsIn vitro tests indicated that rCsTegu21.6 treatment increased the expression of surface molecules, such as CD40 (77%), CD80 (52%) and CD86 (46%), on murine dendritic cells and the secretion of cytokines (TNF‐α, IL‐6, IL‐1β, IL‐10, and IL‐12p70). Moreover, co‐culturing dendritic cells activated by rCsTegu21.6 with allogenic T cells induced T cell proliferation over time. rCsTegu21.6 also stimulated specific antibody production and cytokine secretion [IL‐2, IL‐4, and interferon (IFN)‐γ)] from T cells following immunization in vivo. Notably, rCsTegu21.6 predominantly induced IgG1 production and secretion of the Th2 cytokine IL‐4, regardless of the type of adjuvant used.ConclusionThese results serve as a foundation for the development of tegumental protein‐based vaccines against C. sinensis.

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Prevalence of <i>Clonorchis sinensis</i> Infection among Residents along 5 Major Rivers in the Republic of Korea

Cited by 53 publications

References 11 publications

Infection Status with Digenetic Trematode Metacercariae in Fishes from Coastal Lakes in Gangwon-do, Republic of Korea

Infection Status with Digenetic Trematode Metacercariae in Fishes from Coastal Lakes in Gangwon-do, Republic of Korea

Clonorchis sinensis Infection Presenting as Acute Cholangitis and Acute Cholecystitis

A 21.6 kDa tegumental protein of Clonorchis sinensis induces a Th1/Th2 mixed immune response in mice

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