Prevalence of Lower-Extremity Arterial Calcification in Patients with Diabetes Mellitus Complicated by Foot Disease at an Urban US Tertiary-Care Center

Cárdenas, Vanessa; Seo, Kyung Won; Sheth, Shyam; Meyr, Andrew J.

doi:10.7547/16-075

Cited by 11 publications

(14 citation statements)

References 28 publications

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“…On the other hand, the higher ABIs could be indicative of MAC, which is considered by some researchers to be of similar concern as PAD with regard to cardiovascular events (Nishimura et al, 2016;Suominen et al, 2008). Although MAC is sometimes regarded to be likely only if ABIs are > 1.40 (Bundó et al, 2013;Chen et al, 2016), cutpoints of 1.30, 1.40, and 1.50 have been investigated as prospective cutpoints (Suominen et al, 2008), and even lower ABI cutpoints of 1.20 (McAra et al, 2017) and 1.10 (Cardenas et al, 2018) have been regarded as indicating MAC. Under these circumstances, it is difficult to interpret midrange ABI values with confidence.…”

Section: Issues Associated With Cutpointsmentioning

confidence: 99%

Screening, Sensitivity, Specificity, and So Forth: A Second, Somewhat Skeptical, Sequel

Trevethan

2019

MHS

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This article is concerned with the sensitivity, specificity, predictive values, and other metrics associated with screening tests. It has direct origins in two previous articles. In this third article, the author of the first article writes about topics and issues that were addressed only minimally in his previous article and expands on topics raised by authors of the second article. In particular, attention is turned to wording and terminology that can be idiosyncratic and confusing with regard to screening versus diagnosis as well as to issues associated with reference (“gold”) standards and screening tests, and to the importance of cutpoints and prevalence in relation to metrics associated with screening tests. The primary aims are to help readers attain clarity about topics that they might have felt unsure about; gain reassurance about conceptual difficulties in the field that, once recognized for what they are, can become less problematic because it is possible to be confident about not being confident; and, where appropriate, adopt an appropriately skeptical attitude about screening tests and their associated metrics. Examples are drawn from the use of ankle–brachial and toe–brachial indices for identifying peripheral artery disease, although wider applicability is intended.

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Section: Issues Associated With Cutpointsmentioning

confidence: 99%

Screening, Sensitivity, Specificity, and So Forth: A Second, Somewhat Skeptical, Sequel

Trevethan

2019

MHS

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“…Our protocol successfully captured initial symptom assessment (HIS-r) within 72 h of ED evaluation, at which point participants reported a high total symptom severity. 32 Current research demonstrates 33 , 34 that a higher symptom severity immediately after concussion predicts a prolonged recovery. In our sample of women who experienced IPV-related strangulation, none of our participants reported a low symptom severity or reported as symptom free during any point in our study.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological and Balance Symptoms of Abused Women Who Have Experienced Intimate Partner Violence-Related Strangulation: A Feasibility and Acceptability Study

Muir

Donahue

Broshek

et al. 2022

Neurotrauma Reports

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Intimate partner violence (IPV) is a public health crisis that results in acute and long-term health consequences for women, including potential acquired brain injury from non-fatal strangulation. Despite existing evidence on the neuropsychological sequelae experienced by women after experiencing IPV-related assault, limited evidence-based treatment protocols exist for these women. This 14-month study sought to: 1) assess the feasibility and acceptability of recruiting women who experienced strangulation associated with IPV within 7 days of the event and retaining them throughout a 3-month follow-up period; and 2) examine preliminary data from neuropsychological, balance, and symptom assessments. Inclusion criteria were: reported strangulation by an intimate partner in the past 7 days, female, 18–60 years of age, English speaking, and able to consent. Neuropsychological, balance, and symptom assessments were administered at the first time point and again 3 months later. Participants also completed a standardized daily symptom inventory. Eight participants (73%) were recruited and completed daily inventories and the baseline assessment; 4 (36%) completed the baseline and 3-month assessments. Of the 4 participants who completed the 3-month assessment, none reported symptom resolution. Only balance returned to values consistent with normative values. Our results demonstrate the ability to recruit women who have experienced IPV-related strangulation during the post-acute phase of injury with less success retaining participants for a 90-day period for follow-up study. This pilot research protocol demonstrated the feasibility of recruitment from the emergency department and systematic evaluation of neuropsychological and functional symptoms in women who experienced strangulation in the context of IPV.

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“…Previous studies have shown that radiography and computed tomography can be used to detect ectopic calcification in arteries of diabetic subjects 17,18 . In the present study, we used histology and a nanomaterial-based approach to examine the formation of mineralo-organic particles in human arteries of diabetic subjects.…”

Section: Ectopic Calcification and Formation Of Mineralo-organic Part...mentioning

confidence: 99%

Ectopic calcification and formation of mineralo-organic particles in arteries of diabetic subjects

Martel

Young

2020

Sci Rep

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Vascular calcification occurs in various diseases including atherosclerosis, chronic kidney disease and type 2 diabetes but the mechanism underlying mineral deposition remains incompletely understood. Here we examined lower limb arteries of type 2 diabetes subjects for the presence of ectopic calcification and mineral particles using histology, electron microscopy and spectroscopy analyses. While arteries of healthy controls showed no calcification following von Kossa staining, arteries from 83% of diabetic individuals examined (19/23) revealed microscopic mineral deposits, mainly within the tunica media. Mineralo-organic particles containing calcium phosphate and proteins such as albumin, fetuin-A and apolipoprotein-A1 were detected in calcified arteries. Ectopic calcification and mineralo-organic particles were observed in a majority of diabetic patients and predominantly in arteries showing hyperplasia. While a low number of subjects was examined and information about disease severity and patient characteristics is lacking, these calcifications and mineralo-organic particles may represent signs of tissue dysfunction.

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Prevalence of Lower-Extremity Arterial Calcification in Patients with Diabetes Mellitus Complicated by Foot Disease at an Urban US Tertiary-Care Center

Abstract: The results of this investigation increase the body of knowledge with respect to the evaluation and treatment of diabetic foot disease and may lead to future investigations on the topic of lower-extremity arterial calcification.

Cited by 11 publications

References 28 publications

Screening, Sensitivity, Specificity, and So Forth: A Second, Somewhat Skeptical, Sequel

Screening, Sensitivity, Specificity, and So Forth: A Second, Somewhat Skeptical, Sequel

Neuropsychological and Balance Symptoms of Abused Women Who Have Experienced Intimate Partner Violence-Related Strangulation: A Feasibility and Acceptability Study

Ectopic calcification and formation of mineralo-organic particles in arteries of diabetic subjects

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