Prevalence of low serum cobalamin in infertile couples

Pront, R.; Margalioth, Ehud J.; Green, Ralph; Eldar‐Geva, Talia; Maimoni, Z.; Zimran, Ari; Elstein, Debbie

doi:10.1111/j.1439-0272.2008.00895.x

Cited by 15 publications

(5 citation statements)

References 24 publications

(27 reference statements)

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“…They then measured various physiological variables in the worm, as well as enzymatic activity of MS and MCM, and the concentration of key metabolites. In agreement with human and mouse studies showing fetal loss and infertility under vitamin B12 deplete conditions [32, 36, 37], the brood size of vitamin B12-deficient worms was significantly reduced. In addition, the average lifespan was reduced and animals were shorter.…”

Section: Vitamin B12 Profoundly Affects C Elegans Physiology and Metsupporting

confidence: 88%

Worms, bacteria, and micronutrients: an elegant model of our diet

Yılmaz

Walhout

2014

Trends in Genetics

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Micronutrients are required in small proportions in a diet to carry out key metabolic roles for biomass and energy production. Humans receive micronutrients either directly from their diet or from gut microbiota that metabolize other nutrients. The nematode Caenorhabditis elegans and its bacterial diet provide a relatively simple and genetically tractable model to study both direct and microbe-mediated effects of micronutrients. Recently, this model has been used to gain insight into the relationship between micronutrients, physiology and metabolism. In particular, two B-type vitamins, vitamin B12 and folate, have been studied in detail. Here we review how C. elegans and its bacterial diet provide a powerful interspecies systems biology model that facilitates the precise delineation of micronutrient effects and the mechanisms involved.

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Section: Vitamin B12 Profoundly Affects C Elegans Physiology and Metsupporting

confidence: 88%

Worms, bacteria, and micronutrients: an elegant model of our diet

Yılmaz

Walhout

2014

Trends in Genetics

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“…Hence, worms take it up by ingesting bacteria that absorb the vitamin from the culturing medium [191]. Vitamin B12 deficiency was shown to severely impair C. elegans biology, leading to growth retardation, lifespan shortening and reduced egg-laying capacity, which is consistent with results obtained in mice and humans [187, 192, 193]. Also, memory retention in C. elegans is impaired, partially due to severe oxidative stress [188].…”

Section: Vitaminsmentioning

confidence: 53%

The nutritional requirements of Caenorhabditis elegans

2019

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Animals require sufficient intake of a variety of nutrients to support their development, somatic maintenance and reproduction. An adequate diet provides cell building blocks, chemical energy to drive cellular processes and essential nutrients that cannot be synthesised by the animal, or at least not in the required amounts. Dietary requirements of nematodes, including Caenorhabditis elegans have been extensively studied with the major aim to develop a chemically defined axenic medium that would support their growth and reproduction. At the same time, these studies helped elucidating important aspects of nutrition-related biochemistry and metabolism as well as the establishment of C. elegans as a powerful model in studying evolutionarily conserved pathways, and the influence of the diet on health.

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“…The other significant correlations (Table 2) of folate and cobalamin in serum and seminal plasma in NZ group have been also described [7,25].…”

Section: Discussionmentioning

confidence: 97%

Seminal plasma homocysteine, folate and cobalamin in men with obstructive and non-obstructive azoospermia

Crha

Králíková

Melounová

et al. 2010

J Assist Reprod Genet

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Purpose The aim of this study was to analyze homocysteine, folate and cobalamin in men with normozoospermia, obstructive and non-obstructive azoospermia. Methods Analysis of plasma and seminal plasma homocysteine, folate and cobalamin in 72 azoospermic and 62 normozoospermic men. Evaluation of the azoospermic patient included testicular biopsy, endocrine, urological and ultrasound examination. Results Homocysteine (1.2 μmol/l) and cobalamin (322.05 pmol/l) concentrations (median values) in seminal plasma were significantly lower (p<0.001) in men with azoospermia than in men with normozoospermia (2.5 μmol/ l and 579.0 pmol/l). Folate and cobalamin concentrations were significantly higher in obstructive than in nonobstructive azoospermia. Significant correlations were determined between testis volume and seminal plasma homocysteine in azoospermic men. Conclusion Lower concentrations of homocysteine and cobalamin (but not folate) were found in azoospermic seminal plasma than normozoospermic. Folate and cobalamin were higher in seminal plasma from obstructive azoospermia than in non-obstructive azoospermia patients.

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Prevalence of low serum cobalamin in infertile couples

Cited by 15 publications

References 24 publications

Worms, bacteria, and micronutrients: an elegant model of our diet

Worms, bacteria, and micronutrients: an elegant model of our diet

The nutritional requirements of Caenorhabditis elegans

Seminal plasma homocysteine, folate and cobalamin in men with obstructive and non-obstructive azoospermia

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