Prevalence of low muscle mass according to body mass index in older adults

C, Graf; Pichard, Claude; Herrmann, Françoís; Sieber, Cornel; Zekry, Dina; Genton, Laurence

doi:10.1016/j.nut.2016.10.002

Cited by 47 publications

(45 citation statements)

References 29 publications

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“…One longitudinal study from our group has shown that underweight is a risk factor for incident albuminuria in males [27]. Although this study did not measure body composition, low muscle mass might have mediated the association between underweight and albuminuria [28]. To the best of our knowledge, ours is the first large-scale longitudinal study to have shown that low skeletal muscle mass predicts the future development of albuminuria.…”

Section: Discussionmentioning

confidence: 78%

Low Skeletal Muscle Mass Predicts Incident Dipstick Albuminuria in Korean Adults without Chronic Kidney Disease: A Prospective Cohort Study

Lim

Lee

Kim

et al. 2018

Nephron

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Background: Previous cross-sectional studies have shown that low muscle mass is associated with albuminuria in the general population. However, the longitudinal association of low muscle mass with the development of albuminuria is not well known at this time. Methods: We evaluated 48,101 individuals without chronic kidney disease (CKD) who underwent 2 health check-ups in 2012 and 2016. Participants’ skeletal muscle masses were measured using a bioelectrical impedance analyzer and compared via a skeletal muscle mass index (SMI; SMI [%] = total skeletal muscle mass [kg]/body weight [kg] × 100). Urine albumin was determined by dipstick semi-quantitative analysis and incident albuminuria was defined as ≥1+ dipstick albumin at the time of the second check-up. We used logistic regression analysis to determine the relationship between skeletal muscle mass and incident albuminuria. Results: The study participants were divided into quartiles according to baseline SMI. After 4 years, 305 cases of incident albuminuria were observed. The cumulative incidences of albuminuria were 0.78, 0.66, 0.62, and 0.47% for the first through fourth quartiles of SMI respectively. Multivariable logistic analysis revealed that the ORs (95% CIs) for incident albuminuria were 1.63 (1.05–2.55) in the first quartile compared with those in the fourth quartile and 1.40 (1.05–1.88) in the participants with sarcopenia versus those without sarcopenia. Conclusions: Low skeletal muscle mass was independently associated with the development of dipstick albuminuria after 4 years in Korean adults without CKD. Further research is needed to verify the role of low muscle mass in the development of albuminuria and renal injury.

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Section: Discussionmentioning

confidence: 78%

Low Skeletal Muscle Mass Predicts Incident Dipstick Albuminuria in Korean Adults without Chronic Kidney Disease: A Prospective Cohort Study

Lim

Lee

Kim

et al. 2018

Nephron

View full text Add to dashboard Cite

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“…Additionally, an accurate reporting of the prevalence of sarcopenia continues to be challenging due to differences in the methods used to assess muscle mass and in cutoff values used for diagnosis, and due to variability among study populations such as those who are generally healthy, frail, or have comorbidities. [13] Data from the United States National Health and Nutrition Examination Survey (NHANES) III, which included a large sample of over 4,500 adults aged 60 years and older from multiple ethnicities, found that 59% of women and 45% of men had sarcopenia. [14] These prevalence figures are based on the skeletal muscle mass index which is calculated as skeletal muscle mass (attained using bioelectrical impedance analysis) divided by body mass times 100, and then compared with gender-specific values from younger adults (aged 18 to 39 years) in an approach similar to that used to diagnose osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

“…As a consequence of these differences, prevalence reports for sarcopenia range from about 1 to 85% in the scientific literature. [13,15,16] Yet, while the exact prevalence of sarcopenia among older adults in the United States is not clear, the condition is costly to treat. In the United States, in 2000, the estimated direct health care cost attributable to sarcopenia was 18.5 billion.…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia-A baby boomers dilemma for nurse practitioners to discover, diagnose, and treat

Jackson

Hunt²,

Chapa³

et al. 2018

JNEP

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Objective: Sarcopenia is a disease of low skeletal muscle mass and strength that occurs with aging. It is most commonly seen in individuals aged 50 years and over. Nurse practitioners can take a proactive approach to the understanding and screening of this disease in attempts to prolong its onset or to treat the condition before it leads to additional adverse consequences. Methods: A comprehensive review of the literature, including evidence-based literature from peer-reviewed articles, including randomized controlled trials, was conducted.Results: This review of the literature indicated patients can benefit greatly from nurse practitioner's awareness and intervention by screening for sarcopenia as well as offering appropriate education and treatment to their patients. Once a diagnosis is reached, the nurse practitioner can then collaborate with other disciplines such as nutrition, medicine, exercise physiology and/or physical therapy to develop an intervention strategy that can treat or prevent this condition before it leads to decreased independence, early onset disability and decreased quality of life, among other adverse health outcomes. Conclusions: There is a call to action on the part of nurse practitioners in efforts to prevent and/or slow the onset of age-related sarcopenia and its adverse consequences.

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“…When considered together, the emerging literature on patients with COVID-19 indirectly highlights the relevance of nutrition in possibly determining their outcomes. Older age and the presence of comorbid conditions are almost invariably associated with impaired nutritional status and sarcopenia, independently of body mass index [6]. Interestingly, a high body mass index score appears to be related to a poor prognosis in comorbid patients with COVID-19, which further points to a possible role of sarcopenic obesity in influencing outcome [7].…”

mentioning

confidence: 99%