Prevalence of low back pain in India: A systematic review and meta-analysis

Shetty, Gautam M.; Jain, Shikha; Thakur, Harshad; Khanna, Kriti

doi:10.3233/wor-205300

Cited by 17 publications

(12 citation statements)

References 109 publications

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“…The present study demonstrates a high prevalence of LBP among the surveyed population in Tabuk city. The prevalence of LBP among our participants was 46.2% (95% CI: 42.7-49.8%), which is in line with that reported by a recent systematic review [19] in India (48%, 95% CI 40-56%). Meanwhile, a higher rate was reported by Awaji, [4] who found that the prevalence of LBP in Saudi Arabia ranged from 53.2% to 79.17%.…”

Section: Discussionsupporting

confidence: 91%

Low back pain: Prevalence and functional impairment among the general population in Tabuk city, Saudi Arabia

Waly

Albalawi

Alatawi

et al. 2023

JMSR

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Objectives: Low back pain (LBP) is a main cause of disability worldwide and can negatively affect the individual’s life and work quality. This research aimed to estimate the prevalence of chronic non-specific LBP among the general population of Tabuk city, Saudi Arabia, and to evaluate its related risk factors and functional impairment. Methods: A cross-sectional survey study was performed through a web-based and structured questionnaire consisting of sociodemographic data and risk factors. We used the Modified Oswestry LBP Disability Questionnaire (Arabic version) to measure the disability index among the study participants. The invitation to participate in the questionnaire was posted on different social media platforms. Results: LBP was found in 46% of the participants (n = 768), and it was significantly associated with multiple risk factors, including age group ≥30 years old (P = 0.002), obesity (P = 0.002), smoking (P = 0.004), having comorbidities, particularly anemia, diabetes, hypertension, and hyperthyroidism (P < 0.001), and positive history of psychological problems (P = 0.039). Regular practice of physical activities had a significant protective effect (P = 0.032). The Oswestry Disability Index reported minimal disability among participants who had LBP. Conclusion: The study detected a relatively high prevalence of LBP in Tabuk (46.2%, 95% confidence interval [CI]: 42.7–49.8%) and identified several significant risk factors, including age ≥30 years, body mass index ≥25 kg/m2, smoking, and presence of comorbidities and psychological factors. Regular exercise was a protective factor against chronic LBP. The Oswestry Disability Index showed minimal disability and functional impairment.

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Section: Discussionsupporting

confidence: 91%

Low back pain: Prevalence and functional impairment among the general population in Tabuk city, Saudi Arabia

Waly

Albalawi

Alatawi

et al. 2023

JMSR

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“…According to the World Health Organization report [10], musculoskeletal conditions are reported among 1.71 billion people across the globe, in which Low back pain is the main contributor with 570 million cases globally. As per the literature [11], the annual and lifetime prevalence of LBP in India stands at 51% (95% CI 45-58%) and 66% (95% CI 56-75%) respectively. [12] Intervertebral disc is largely avascular, hypoxia, low pH, high osmotic pressure and executes high mechanical load [13][14][15] and such an unique environment makes it challenging for the exogenous cell therapy to accomplish the objective i.e., treatment of IVDD.…”

Section: How To Citementioning

confidence: 82%

A Review on Cartilaginous Endplates and the Degeneration of Intervertebral Disc

Allah¹

2021

Int. J. Med. Sci.

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Cartilaginous Endplates (CEP) acts as a mechanical barrier and forms the anatomical structure of intervertebral disc. It allows the nutrients to get transported into the disc from the nearby blood vessels. Low back pain is a primary complication raised by Intervertebral Disc Degeneration (IVDD). The objective of the current review article is to provide an overview about the composition and the functions of Cartilaginous Endplates, development and the progression of the IVDD, application of modern techniques for its treatment. CEP primarily contains water, type II collagen, glycosaminoglycans (GAGs) while it also has type X collagen. The study provided an overview about the IVDD, causal factors, diagnostic methods and the application of different types of treatment methods. The authors recommend to validate the stem cell-based therapies at clinical levels since such therapies have been proposed and validated so far, only in in vitro and animal models. Further, the study recommends to develop novel diagnostic tools that are not only cost-effective, but also non-invasive by leveraging the Artificial Intelligence and Machine Learning techniques in the diagnostics methods.

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“… 1 According to a meta-analysis, the prevalence of LBP is approximately 48–66%. 2 Acute or chronic LBP affects the health of patients and causes an enormous impact on individuals and communities throughout the world. 1 Therefore, it is important to understand the pathological and pathophysiological mechanisms underlying the prevention and treatment of LBP.…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species Induced Upregulation of TRPV1 in Dorsal Root Ganglia Results in Low Back Pain in Rats

Chen,

et al. 2024

JIR

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Background Dorsal root ganglia (DRGs) contain sensory neurons that innervate intervertebral discs (IVDs) and may play a critical role in mediating low-back pain (LBP), but the potential pathophysiological mechanism needs to be clarified. Methods A discogenic LBP model in rats was established by penetration of a lumbar IVD. The severity of LBP was evaluated through behavioral analysis, and the gene and protein expression levels of pro-algesic peptide substance P (SP) and calcitonin gene–related peptide (CGRP) in DRGs were quantified. The level of reactive oxygen species (ROS) in bilateral lumbar DRGs was also quantified using dihydroethidium staining. Subsequently, hydrogen peroxide solution or N-acetyl-L-cysteine was injected into DRGs to evaluate the change in LBP, and gene and protein expression levels of transient receptor potential vanilloid-1 (TRPV1) in DRGs were analyzed. Finally, an inhibitor or activator of TRPV1 was injected into DRGs to observe the change in LBP. Results The rats had remarkable LBP after disc puncture, manifesting as mechanical and cold allodynia and increased expression of the pro-algesic peptides SP and CGRP in DRGs. Furthermore, there was significant overexpression of ROS in bilateral lumbar DRGs, while manipulation of the level of ROS in DRGs attenuated or aggravated LBP in rats. In addition, excessive ROS in DRGs stimulated upregulation of TRPV1 in DRGs. Finally, activation or inhibition of TRPV1 in DRGs resulted in a significant increase or decrease of discogenic LBP, respectively, suggesting that ROS-induced TRPV1 has a strong correlation with discogenic LBP. Conclusion Increased ROS in DRGs play a primary pathological role in puncture-induced discogenic LBP, and excessive ROS–induced upregulation of TRPV1 in DRGs may be the underlying pathophysiological mechanism to cause nerve sensitization and discogenic LBP. Therapeutic targeting of ROS or TRPV1 in DRGs may provide a promising method for the treatment of discogenic LBP.

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Prevalence of low back pain in India: A systematic review and meta-analysis

Cited by 17 publications

References 109 publications

Low back pain: Prevalence and functional impairment among the general population in Tabuk city, Saudi Arabia

Low back pain: Prevalence and functional impairment among the general population in Tabuk city, Saudi Arabia

A Review on Cartilaginous Endplates and the Degeneration of Intervertebral Disc

Reactive Oxygen Species Induced Upregulation of TRPV1 in Dorsal Root Ganglia Results in Low Back Pain in Rats

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