Prevalence of left ventricular diastolic dysfunction in the community Results from a Doppler echocardiographic-based survey of a population sample

Fischer, Marcus; Baessler, Andrea; Hw, Hense; Hengstenberg, Christian; Muscholl, M.; Holmer, Stephan; Döring, Angela; Broeckel, Ulrich; Riegger, Günter A.J.; Schunkert, Heribert

doi:10.1016/s0195-668x(02)00428-1

Cited by 354 publications

(253 citation statements)

References 33 publications

Supporting

Mentioning

207

Contrasting

Unclassified

Order By: Relevance

“…Myocardial processes changing LV diastolic function are naturally associated with aging and can contribute to the development of symptoms in the elderly. 21 Older patients with HOCM typically show a relatively milder degree of LV hypertrophy, 9,22,23 which we also observed. Some of them have a high resting LVOT gradient caused by mitral -septal contact associated with normally sized mitral leaflets being displaced anteriorly and relatively mild septal hypertrophy with proximal bulge.…”

Section: Discussionsupporting

confidence: 74%

Age-Related Hemodynamic and Morphologic Differences in Patients Undergoing Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy

Veselka

Duchoňová

Páleníc̆ková

et al. 2006

Circ J

View full text Add to dashboard Cite

Background Alcohol septal ablation (ASA) decreases the left ventricular (LV) outflow gradient and relieves symptoms in patients with highly symptomatic hypertrophic obstructive cardiomyopathy (HOCM). The aim of this study was to evaluate the early course of hemodynamic, morphologic and clinical changes in younger and elderly patients. Methods and Results Forty-four consecutive patients (age, 24-81 years) underwent the ASA procedure for HOCM. Clinical and echocardiographic data were obtained at baseline and periodically up to 12 months after ASA. There was a significant correlation between septum thickness and age at baseline and in the early post procedural period (p=0.004 at baseline, p=0.0033 days postoperative, p=0.0193 weeks pos operative). The dependence of septal thickness on the duration of follow-up (p<0.001) was significantly influenced by age (p=0.026), which retained statistical significance after multivariate adjustment (p=0.031). A decrease in the gradient of the LV outflow was identified in all age-related groups of patients (p<0.001). After multivariate adjustment, there was a significant influence of age (p=0.003) and creatine kinase-MB peak (p=0.016) on the course of outflow gradient reduction. Conclusions ASA is an effective treatment option for patients with HOCM, irrespective of their age. Younger patients are characterized by a thicker basal septum at baseline and a slower hemodynamic improvement within the early post procedural period. (Circ J 2006; 70: 880 -884)

show abstract

Section: Discussionsupporting

confidence: 74%

Age-Related Hemodynamic and Morphologic Differences in Patients Undergoing Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy

Veselka

Duchoňová

Páleníc̆ková

et al. 2006

Circ J

View full text Add to dashboard Cite

show abstract

“…The prevalence reported here (between 20 % and 24 %) is consistent with larger population studies [26][27][28][29].…”

Section: Prevalence Of Diastolic Dysfunctionsupporting

confidence: 91%

Cardiovascular magnetic resonance imaging assessment of diastolic dysfunction in a population without heart disease: a gender-based study

et al. 2013

View full text Add to dashboard Cite

Objectives Asymptomatic left ventricular (LV) diastolic dysfunction is increasingly recognised as an important diagnosis. Our goal was to study the prevalence and gender differences in subclinical LV diastolic dysfunction, using cardiovascular magnetic resonance imaging (CMR) at 3 T. Methods We prospectively studied 48 volunteers (19 male and 29 female, mean age 49±7 years) with no evidence of cardiovascular disease. We used CMR to measure left atrium (LA) and LV volumes, LV peak filling rate and transmitral flow.Results The overall prevalence of LV diastolic dysfunction in our cohort varied between 20 % (based on evaluation of LV filing profiles) and 24 % (based on the evaluation of the transmitral flow). The prevalence of diastolic dysfunction was higher in men than in women, independently of the criteria used (P between 0.004 and 0.022). Indexed LV end-diastolic volume, indexed LV stroke volume, indexed LV mass, indexed LA minimum volume and indexed LA maximum volume were significantly greater in men than in women (P<0.05). All the subjects had LV ejection fractions within the normal range. Conclusions It is clinically feasible to study diastolic flow and LV filling with CMR. CMR detected diastolic dysfunction in asymptomatic men and women. Key Points • CMR imaging offers new possibilities in assessing left ventricular diastolic function.• The prevalence of diastolic dysfunction is higher in men than in women.• The prevalence of some diastolic dysfunction in a normal population is 24 %.

show abstract

“…Predisposing conditions for the development of DD include hypertension, LV hypertrophy (LVH), older age, female gender, obesity, diabetes, chronic kidney disease and coronary artery disease (CAD) 10 , 11 . LV filling is impaired (abnormalities of active relaxation and passive stiffness of the myocardium) in combination with abnormal ventriculo‐arterial coupling 12 , 13 .…”

Section: Likely Mechanisms For Diastolic Dysfunctionmentioning

confidence: 99%

Echocardiographic evaluation of diastolic heart failure

Thomas

2010

Australas J Ultrason Med

View full text Add to dashboard Cite

Prevalence of left ventricular diastolic dysfunction in the community Results from a Doppler echocardiographic-based survey of a population sample

Cited by 354 publications

References 33 publications

Age-Related Hemodynamic and Morphologic Differences in Patients Undergoing Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy

Age-Related Hemodynamic and Morphologic Differences in Patients Undergoing Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy

Cardiovascular magnetic resonance imaging assessment of diastolic dysfunction in a population without heart disease: a gender-based study

Echocardiographic evaluation of diastolic heart failure

Contact Info

Product

Resources

About