Prevalence of latent tuberculosis infection among pre-clinical and clinical medical students using QuantiFERON-TB gold plus and tuberculin skin test at a teaching hospital in Thailand: A cross-sectional study

Chumpa, Nuntana; Kawkitinarong, Kamon; Wongpiyabovorn, Jongkonnee; Paitoonpong, Leilani; Suwanpimolkul, Gompol

doi:10.1016/j.jiph.2022.02.010

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…were comparable with those of Nienhaus et al,20 in Europe who found a positive 25% of IFN-γ suggestive of latent tuberculosis among HCWs and roughly similar to that done by Abbas et al,21 in Saudi Arabia; the positive rate of IFN-γ among HCWs was 18%. In addition, the positive rate of IFN-γ among HCWs in current study was lower than the rate reported by Chen et al, in southern China recently where the positive rate of IFN-γ among healthcare workers was 33.9% 22 , while low rates were reported by Hung et al, (14.5%)23 and Shumba et al,24 (6.3%) among health care workers in central of China and Thailand respectively.…”

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confidence: 81%

Prevalence and Risk Factors of Latent Tuberculosis Among Healthcare Workers in Sana’a City, Yemen Using Whole Blood Interferon-Γ Release Assay

et al. 2022

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Background and aims: Tuberculosis (TB) is a critical problem of public health. Diagnosis and screening of latent Mycobacterium tuberculosis infections (LTBI) are essential to control their spread. The goal of the study was to clarify the prevalence and risk factors for LTBI using IGRA among healthcare works (HCWs) in Sana’a city, Yemen. Methods: The cross-sectional study was performed in three chosen tertiary hospitals in Sana'a city. Healthcare workers who participated in this survey were asked to complete a questionnaire and donate 5 ml of blood to perform the IGRA. A total of 180 healthcare workers were involved in this study; aged 20-60 years, 45.6% males and 54.4% females. Blood samples were collected and then tested by Interferon-gamma (IFN-γ) release assays that measure the presence of specific M. tuberculosis reactive T-cells sensitized by a previous infection with M. tuberculosis using the Quanti FERON-TB Gold In Tube assay (QFT-GIT). The data were evaluated for the positive association of interferon-gamma. Results: The overall positivity rate IFN-γ of our healthcare workers was 20%, and for females it was 28.6%, with an associated odds ratio equal to 3.7, CI=1.5-8.7, P=0.001, while for males it was only 9.7%. Positive rates IFN-γ increased with increasing age, as a high IFN-γ positive rate occurred in the 50-60-year age group was 50%, with OR=5.5, CI=2.2-13.6, P < 0.001. There was a significant association between IFN-γ positive latent tuberculosis and unimmunized childhood BCG (OR=2.2, CI=1.03-4.7, P=0.03), diabetics (OR=4.2, CI=1.5-12, P=0.003), smoking (OR=2.7, CI=1.2-6.1, P=0.009) and contacting cases with active TB (OR=4.1, CI=1.4-12.2, P=0.007). Conclusion: It was found that the rate of LTBI among HCWs is high in Sana'a, central Yemen. Factors at both the institutional and individual level can influence the prevalence of LTBI among HCWs. Since contact with active TB patients has been identified as a risk factor for LTBI, more effective TB infection control measures are necessary in health care facilities and congregate settings and to create awareness about TB risk factors in hospitals and as an occupational hazard. Peer Review History: Received: 5 September 2022; Revised: 17 October; Accepted: 6 November, Available online: 15 November 2022 Academic Editor: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com Dr. Wadhah Hassan Ali Edrees, Hajja University, Yemen, edress2020@gmail.com Similar Articles: DETERMINATION OF RIFAMPICIN MONO-RESISTANCE MYCOBACTERIUM TUBERCULOSIS IN THE NATIONAL TUBERCULOSIS CONTROL PROGRAMME IN SANA'A CITY-YEMEN: A SIGNIFICANT PHENOMENON IN WAR REGION WITH HIGH PREVALENCE TUBERCLOISIS

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confidence: 81%

Prevalence and Risk Factors of Latent Tuberculosis Among Healthcare Workers in Sana’a City, Yemen Using Whole Blood Interferon-Γ Release Assay

et al. 2022

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“…It has been reported that TST caused more false-positive results compared to QFT testing due to the influence of BCG vaccination or other mycobacterial infections [7,22]. Recent studies reported the prevalence of LTBI among Thai HCWs and medical students assessed by QFT-Plus at 14.71% and 6.3%, respectively [23][24]. These figures were lower than the prevalence estimate of 32.73% in Thai nursing professionals working in a tertiary-care center reported recently [25] and lower than those in this study.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, Risk Factors, and Result Features in the Detection of Latent Tuberculosis Infection in Thai Healthcare Workers Using QuantiFERON-TB Gold Plus

Klayut,

Srisungngam,

Suphankong

et al. 2024

Cureus

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IntroductionLatent tuberculosis infection (LTBI) is an enormous reservoir for tuberculosis (TB), and healthcare workers (HCWs) are at high risk for TB infection. QuantiFERON-TB Gold Plus (QFT-Plus) is an alternative to the tuberculin skin test for LTBI detection, but data on its application and LTBI detected by QFT-Plus in high TB burden countries are limited. This study aimed to determine the prevalence of LTBI and its risk factors, and to investigate the QFT-Plus results in Thai HCWs. MethodsA cross-sectional analytical study was conducted among HCWs at a secondary care hospital in Health Region 5, Thailand. Eligible HCWs were enrolled and underwent QFT-Plus testing. Interferon-gamma (IFN-γ) values in tubes were analysed. The prevalence and associated risk factors for LTBI were assessed based on laboratory and sociodemographic data. Logistic regression analyses were applied to calculate odds ratios (OR, aOR) reported with 95% confidence intervals (CI). ResultsOf the 269 participants enrolled, their median age was 42 years and 93.31% (n = 251/269) were female. The majority (n = 178/269, 66.17%) were nurses or nurse assistants and 42.75% (n = 115/269) worked in the inpatient medical wards. Overall, the QFT-Plus results showed 110 (40.89%) positive with good agreement (93.68%; κ 0.87) and high correlation (Spearman's ρ 0.91) of IFN-γ concentrations in the two antigen tubes. A true difference in IFN-γ values for predicting a recent infection was found about 7.81% (n = 21/269). By univariate and multivariate analyses, the participants' age > 40 years (

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“… 10 Changes in tuberculin reagent can affect TST results. 31 To mitigate challenges for TPT eligibility, high-burden countries may choose to give TPT to household contacts of all ages after excluding TB disease and assessing clinical risk if TBI diagnostic testing is unavailable or unreliable. 2 , 32 Countries using TST to determine eligibility for TPT should monitor tuberculin reagent, potency, and cold chain, as well as TST quality assurance.…”

Section: Discussionmentioning

confidence: 99%

Tuberculin skin testing and QuantiFERON™-TB Gold Plus positivity among household contacts in Vietnam

Innes,

Nguyen,

Lebrun

et al. 2023

public health action

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SETTING: TB infection (TBI) is diagnosed using the technique-dependent tuberculin skin test (TST) or costly, more accurate interferon-gamma release assays. The TST (10 mm) threshold was indicated by previous research among household contacts in Vietnam, but routine implementation with a different tuberculin reagent showed unexpectedly low TST positivity.OBJECTIVE: TST (5 mm and 10 mm) results were compared to QuantiFERON™-TB Gold Plus (QFT) results in household contacts during community campaigns in 2020 and 2021.DESIGN: This was a cross-sectional multi-center implementation study.RESULTS: Among 1,330 household contacts in 2020, we found a TBI prevalence of 38.6% (QFT), similar to TST 5 mm (37.4%) and higher than TST 10 mm (13.1%). QFT+/TST+ was higher for TST 5 mm (20.7%) than TST 10 mm (9.4%). QFT was not discordant with TST 5 mm (McNemar’s test = 0.6, P = 0.5) but was discordant with TST 10 mm (McNemar’s test = 263.9, P < 0.01). Older age and Southern region increased odds for positive TST 5 mm and QFT with weaker associations for TST 10 mm. Agreement and discordance were similar in 2021 for 1,158 household contacts.CONCLUSION: Tuberculin reagents affect TST positivity rates. High TB burden countries should monitor reliability of TBI diagnosis, including tuberculin potency, cold chain, and TST technique to optimize eligibility for TB preventive treatment.

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Prevalence of latent tuberculosis infection among pre-clinical and clinical medical students using QuantiFERON-TB gold plus and tuberculin skin test at a teaching hospital in Thailand: A cross-sectional study

Cited by 6 publications

References 12 publications

Prevalence and Risk Factors of Latent Tuberculosis Among Healthcare Workers in Sana’a City, Yemen Using Whole Blood Interferon-Γ Release Assay

Prevalence and Risk Factors of Latent Tuberculosis Among Healthcare Workers in Sana’a City, Yemen Using Whole Blood Interferon-Γ Release Assay

Prevalence, Risk Factors, and Result Features in the Detection of Latent Tuberculosis Infection in Thai Healthcare Workers Using QuantiFERON-TB Gold Plus

Tuberculin skin testing and QuantiFERON™-TB Gold Plus positivity among household contacts in Vietnam

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