Prevalence of latent tuberculosis infection among healthcare workers in China as detected by two interferon-gamma release assays

Zhuo, Wei; Yang, M.; Quan, Bin; Wang, Y.; Wu, Yinong; Ji, B.

doi:10.1016/j.jhin.2013.04.015

Cited by 13 publications

(18 citation statements)

References 9 publications

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“…Studies have shown that there are different risk factors that contribute to the transmission of TB in health care centres [5, 9, 10]. Healthcare workers are a group with a higher probability of acquiring TB rather than the general population [5], hence the importance of this study’s findings.…”

Section: Discussionmentioning

confidence: 86%

“…Studies have shown that there are different risk factors for LTBI in the healthcare centres [5, 9, 10]. Researchers have documented the TB risk factors faced by HCWs worldwide which includes advanced age, sex (male), smoking, years of employment, professional category (physicians and nurses, working closely with patients), delayed diagnosis and misdiagnosis in patients, absence of suspicious clinical signs, lack or inadequacy of personal protective equipment and preventive measures [2, 3, 11–14].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique

Belo

Naidoo

2017

BMC Infect Dis

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BackgroundHealthcare workers in high tuberculosis burdened countries are occupationally exposed to the tuberculosis disease with uncomplicated and complicated tuberculosis on the increase among them. Most of them acquire Mycobacterium tuberculosis but do not progress to the active disease – latent tuberculosis infection. The objective of this study was to assess the prevalence and risk factors associated with latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique.MethodsThis cross-sectional study of healthcare workers was conducted between 2014 and 2015. Participants (n = 209) were administered a questionnaire on demographics and occupational tuberculosis exposure and had a tuberculin skin test administered. Multivariate linear and logistic regression tested for associations between independent variables and dependent outcomes (tuberculin skin test induration and latent tuberculosis infection status).ResultsThe prevalence of latent tuberculosis infection was 34.4%. Latent tuberculosis infection was highest in those working for more than eight years (39.3%), those who had no BCG vaccination (39.6%) and were immunocompromised (78.1%). Being immunocompromised was significantly associated with latent tuberculosis infection (OR 5.97 [95% CI 1.89; 18.87]). Positive but non-significant associations occurred with working in the medical domain (OR 1.02 [95% CI 0.17; 6.37]), length of employment > eight years (OR 1.97 [95% CI 0.70; 5.53]) and occupational contact with tuberculosis patients (OR 1.24 [95% CI 0.47; 3.27]).ConclusionsPersonal and occupational factors were positively associated with latent tuberculosis infection among healthcare workers in Mozambique.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique

Belo

Naidoo

2017

BMC Infect Dis

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“…Indeed, we included one study published in a journal in Portuguese and had the abstract in English was identified through our search [ 22 ]. Despite interpretational challenges, studies have reported both lower and higher prevalence of LTBI by IGRA compared to TST in TB high burden countries [ 38 , 40 ]. As a result, our estimates of LTBI burden may be an under or overestimate of the actual burden among health care workers.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Latent Tuberculosis among Health Care Workers in High Burden Countries: A Systematic Review and Meta-Analysis

2016

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BackgroundTuberculosis is one of the leading causes of death worldwide. Twenty-two high burden countries contributed to the majority of worldwide tuberculosis cases in 2015. Health care workers are at high risk of acquiring tuberculosis through occupational exposure.ObjectiveTo estimate the prevalence of latent tuberculosis infection (LTBI) among health care workers in high burden countries.MethodsDatabases including MEDLINE (Ovid), EMBASE (Ovid), CINAHL (Ovid) and ISI Web of Science (Thompson-Reuters), and grey literature were searched for English language records on relevant medical subject headings (MeSH) terms of LTBI and health care providers. Literature was systematically reviewed using EPPI-Reviewer4 software. Prevalence and incidence of LTBI and 95% confidence intervals (CI) were reported. Pooled prevalence of LTBI and 95% CI were calculated using random-effects meta-analysis models and heterogeneity was assessed using I2 statistics. Sub-group analysis was conducted to assess the cause of heterogeneity.ResultsA total of 990 records were identified. Of those, 18 studies from only 7 high burden countries representing 10,078 subjects were included. Tuberculin skin test results were available for 9,545 participants. The pooled prevalence of LTBI was 47% (95% CI 34% to 60%, I2 = 99.6%). In subgroup analyses according to the country of the study, the pooled prevalence of LTBI was lowest in Brazil (37%) and highest in South Africa (64%). The pooled prevalence of LTBI among medical and nursing students was 26% (95% CI 6% to 46%, I2 = 99.3%) while the prevalence among all types of health care workers was 57% (95% CI 44% to 70%, I2 = 99.1%). Incidence of LTBI was available for health care workers in four countries. The cumulative incidence ranged from 2.8% in Brazilian medical students to 38% among all types of health care workers in South Africa.ConclusionThe findings of this study suggest that there is a high burden of LTBI among health care workers in high burden countries. Adequate infection control measures are warranted to prevent and control transmission in health care settings.

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“…12 Previous studies have shown different risk factors for LTBI among healthcare workers in a number of healthcare centers. [13][14][15] Risk factors for TB in healthcare workers throughout the world increase the risk of being infected with the disease. These factors include age, gender (male), smoking habits, length of work, professional groups (doctors and nurses, working with patients), late diagnosis and misdiagnosis in patients, no suspected clinical signs, and the lack or insufficiency of personal protective equipment and preventive measures.…”

Section: Introductionmentioning

confidence: 99%

<p>The Prevalence and Demographic Risk Factors for Latent Tuberculosis Infection (LTBI) Among Healthcare Workers in Semarang, Indonesia</p>

Erawati¹,

Andriany²

2020

JMDH

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Purpose: To determine the prevalence and demographic risk factors for latent tuberculosis infection (LTBI) among healthcare workers in Semarang, Indonesia. Methods: A cross-sectional study involving 195 healthcare workers from 34 primary health centers was conducted from August to October 2019. The relationship between independent variables and dependent variables was analyzed using a multivariable logistic regression analysis. Results: The prevalence of LTBI among healthcare workers in this study was 23.6%. Comorbidities were the only risk factor for LTBI identified among other risk factors (OR=3.39, 95% CI: 0.99-11.62, p=0.04). Other demographic factors such as age (OR=0.93, 95% CI: 0.45-1.92, p=0.839), gender (OR=0.79, 95% CI: 0.23-2.72, p=0.708, smoking habits (OR=2.54, 95% CI: 0.52-12.38, p=0.247), and length of work (OR=1.43, 95% CI: 0.70-2.91, p=0.331) were not significant risk factors for LTBI. Conclusion: Healthcare workers suffering from comorbidity have a high risk for tuberculosis infection, and should not work in areas where they would be exposed to patients with tuberculosis. Healthcare workers need to apply occupational safety standards during contact with TB patients or specimens to minimize the disease transmission.

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Prevalence of latent tuberculosis infection among healthcare workers in China as detected by two interferon-gamma release assays

Cited by 13 publications

References 9 publications

Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique

Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique

Prevalence of Latent Tuberculosis among Health Care Workers in High Burden Countries: A Systematic Review and Meta-Analysis

<p>The Prevalence and Demographic Risk Factors for Latent Tuberculosis Infection (LTBI) Among Healthcare Workers in Semarang, Indonesia</p>

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