Prevalence of late-life depression and its correlates in a community-dwelling low-educated population aged 75+ years: The Pietà study

Dias, Filipi Leles da Costa; Teixeira, Antônio Lúcio; Guimarães, Henrique Cerqueira; Santos, Ana Paula; Ritter, Simone Rios Fonseca; Machado, João Carlos; Barbosa, Maira Tonidandel; Caramelli, Paulo

doi:10.1016/j.jad.2018.08.012

Cited by 29 publications

(12 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prevalence in late-life depression was twice in southern Europe compared to Scandinavia. In a recent study, the prevalence of LLD in Brazil was approximately 11.1% in patients over 75 years, which was quite similar to the prevalence reported in Europe [5].…”

Section: Epidemiologysupporting

confidence: 73%

Depression in the Elderly–Epidemiology, Diagnosis, Special Aspects, and Treatment Options

Koch¹

2019

obm geriatr

View full text Add to dashboard Cite

The prevalence of Late-life Depression (LLD) has been estimated between 10% and 15%. Therefore, it is a considerable worldwide problem. The psychopathology is not substantially different from that of depressive episodes in young adults but somatic complaints in combination with end-of-life perspective leave an imprint on emotional experience. The frequent suicidal tendency, especially in old unmated men, remains a particular challenge. It is important to combine psychiatric and somatic diagnostics using modern methods such as cMRT (magnetic resonance tomography) or extensive clinical laboratory to exclude organic underlying diseases. The treatment is a multidisciplinary approach and includes biological, psychotherapeutic and physiotherapeutic or socio-therapeutically methods. Modern antidepressants and augmentation strategies allow treating the old-aged population with sufficient safety, tolerability, and therapeutic efficiency.

show abstract

Section: Epidemiologysupporting

confidence: 73%

Depression in the Elderly–Epidemiology, Diagnosis, Special Aspects, and Treatment Options

Koch¹

2019

obm geriatr

View full text Add to dashboard Cite

show abstract

“…In a systematic review investigating the prevalence of depressive morbidity in Brazilian older adults, the authors found a rate of over 7% for MDD, 26% for CSDS and 3.3% for dysthymia 13. The Pietà study showed that 26.5% of community-dwelling individuals aged 75+ years have had CSDS 15…”

Section: Resultsmentioning

confidence: 99%

<p>Subthreshold Depression Needs A Prime Time In Old Age Psychiatry? A Narrative Review Of Current Evidence</p>

Biella¹,

Borges²,

Strauss³

et al. 2019

NDT

View full text Add to dashboard Cite

This study aims to carry out a narrative review, aiming to update the literature on subsyndromic depression (SD), which is the most prevalent depressive disorder in older adults, and no formal guidelines or consensus are dedicated to this topic. We carried out an electronic search for articles on SD. Relevant articles were retrieved from Pubmed, EMBASE and Web of Science using the search terms "subthreshold depression," "prevalence," "treatment" and "older adults" in several combinations. Original articles in English were included from inception to 1st March 2019. No clear consensus exists in the literature on its nosologic classification, diagnostic tools, causes, course, outcomes or management. SD diagnosis should base in depressive symptoms scales and DSM criteria. Treatment relies mainly on collaborative care and psychotherapy. SD is relevant in clinical practice and research in geriatric psychiatry. Given the negative outcomes and potential benefits of treatment, we recommend brief psychotherapy as first-line treatment and use of psychotropic agents in cases with greater severity and/or functional impairment in association with psychotherapy. SD can precede major depressive disorder, but it also may consist of a primary depressive disorder in older adults. Furthermore, adequate treatment of SD can prevent or reduce negative outcomes associated with depressive symptoms such as worsening of clinical comorbidities, loss of functionality, increased demand for health services, and increased mortality.

show abstract

“…Depression is the most common mental disorder in the growing geriatric population (1). Late-life depression (LLD) is associated with physical and cognitive deficits and the poor treatment responses of these patients, which results in a heavy economic and emotion burden to their families (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Changes of Altruistic Behavior and Kynurenine Pathway in Late-Life Depression

Mai

Weng

et al. 2020

Front. Psychiatry

View full text Add to dashboard Cite

Background: Depressive patients show less altruistic behavior. While, older adults present higher tendencies for altruism than younger adults. Depression and age are two of the influencing factors of altruism, kynurenine (KYN), and its metabolites. However, the characteristics of altruism in late-life depression (LLD) and its possible underlying mechanism have not been studied.Objective: We aimed to explore the characteristics of altruism in LLD patients and its neurobiological mechanism and structural brain network. We investigated whether the levels of metabolites in kynurenine pathway (KP) and white matter (WM) network topological features would influence the altruistic behavior in LLD patients.Methods: Thirty-four LLD patients and 36 heathy controls (HCs) were included. Altruism was evaluated by the Dictator Game (DG) paradigm. Serum concentrations of KP metabolites were detected by the liquid chromatography-tandem mass spectrometry method. The topological features of the WM network were calculated from diffusion tensor imaging data in conjunction with graph-theoretical analysis.Results: The LLD participants exhibited a higher level of altruism and WM global network properties than the HCs. Kynurenic acid to kynurenine (KYNA/KYN) ratio was associated with the DG performance in LLD group. KYNA/KYN ratio was associated with the WM network properties in HC group.Conclusions: KYN metabolism played an important role in altruistic behavior in LLD.

show abstract

Prevalence of late-life depression and its correlates in a community-dwelling low-educated population aged 75+ years: The Pietà study

Cited by 29 publications

References 40 publications

Depression in the Elderly–Epidemiology, Diagnosis, Special Aspects, and Treatment Options

Depression in the Elderly–Epidemiology, Diagnosis, Special Aspects, and Treatment Options

<p>Subthreshold Depression Needs A Prime Time In Old Age Psychiatry? A Narrative Review Of Current Evidence</p>

Changes of Altruistic Behavior and Kynurenine Pathway in Late-Life Depression

Contact Info

Product

Resources

About