Prevalence of known and previously unknown diabetes mellitus and impaired glucose tolerance in an adult Norwegian population. Indications of an increasing diabetes prevalence. the Nord-Trøndelag diabetes study

Midthjell, Kristian; Bjørndal, Arild; Holmen, Jostein; Krüger, Ø; Bjartveit, K

doi:10.3109/02813439508996766

Cited by 38 publications

(31 citation statements)

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“…Five patients used insulin as monotherapy and insulin was combined with peroral antidiabetic drugs in 23 patients. The prevalence of diabetes mellitus in this region of Norway was 4.8% in men and 5.6% in women during 1984Á 1986 according to the Nord-Trøndelag diabetes study [12].…”

Section: Methodsmentioning

confidence: 99%

Diabetes mellitus and outcomes of colorectal cancer

et al. 2009

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Section: Methodsmentioning

confidence: 99%

Diabetes mellitus and outcomes of colorectal cancer

et al. 2009

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“…Nord-Trøndelag health study From 1984 to 1986, all inhabitants of the Norwegian county of Nord-Trøndelag who were aged 20 years or older were invited to take part in the Nord-Trøndelag Health Study (HUNT1) (n=85,100) [4,5]. The survey featured a clinical examination, including measurements of height, weight and blood pressure, and questionnaires with questions on current health, diabetes and lifestyle factors such as smoking, alcohol consumption, physical activity and psychosocial conditions.…”

Section: Methodsmentioning

confidence: 99%

Age, overweight and physical inactivity increase the risk of latent autoimmune diabetes in adults: results from the Nord-Trøndelag health study

et al. 2006

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Aims/hypothesis Latent autoimmune diabetes (LADA) is a common form of diabetes, yet the risk factors are poorly characterised. The aim of this study was to investigate the influence of age, overweight and physical activity on the risk of LADA. Methods We analysed age, overweight and physical inactivity and the incidence of LADA in 38,800 men and women, observed between 1984 and 1986 and 1995 and 1997 as part of the Nord-Trøndelag Health Survey. We also compared such factors with incident cases of type 2 (n=738) and 'classic' type 1 diabetes (n=18). Patients classified as LADA (n=81) had antibodies against GAD and were insulin independent at diagnosis. Results The proportion of those who were older, overweight and inactive before diagnosis was almost identical in LADA and type 2 diabetes patients. BMI ≥30 kg/m 2 was strongly associated with LADA incidence (relative risk [RR]=15.0, 95% CI 7.51-29.97). The association was similar for type 2 diabetes (RR=15.37, 95% CI 12.07-19.57) but not for type 1 diabetes. Similarly, age (≥60 years) was an important risk factor for LADA (RR= 5.62, 95% CI 2.36-13.4) as well as for type 2 diabetes (RR=6.78, 95% CI 5.07-9.06) in contrast to type 1 diabetes. Physical inactivity was associated with an increased risk of both LADA and type 2 diabetes. Conclusions/interpretation This study suggests that increased age, overweight and physical inactivity are as strong risk factors for LADA as for type 2 diabetes. These findings suggest a role for insulin resistance in the pathogenesis of LADA.Keywords Age . Epidemiology . Incidence . Latent autoimmune diabetes in adults . Overweight . Physical inactivityAbbreviations AP attributable proportion LADA latent autoimmune diabetes in adults RR relative risk Diabetologia (2007) 50:55-58

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“…From 1984 to 1986, all inhabitants of the Norwegian county of Nord-Trøndelag who were aged Ն20 years were invited to take part in HUNT 1 (n ϭ 85,100) (12). The survey featured a clinical examination, including measurements of height, weight, and blood pressure and question-naires with questions on current health, diabetes, and lifestyle factors such as smoking and alcohol consumption.…”

Section: Huntmentioning

confidence: 99%

Influence of Family History of Diabetes on Incidence and Prevalence of Latent Autoimmune Diabetes of the Adult

2007

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OBJECTIVE -The aim of this study was to investigate the association between family history of diabetes (FHD) and prevalence and incidence of latent autoimmune diabetes of the adult (LADA), type 1 diabetes, and type 2 diabetes. RESEARCH DESIGN AND METHODS -The results were based on cross-sectional data from 64,498 men and women (aged Ն20 years) who were in the Nord-Trøndelag Health Study, which included 128 cases of LADA, 1,134 cases of type 2 diabetes, and 123 cases of type 1 diabetes. In addition, prospective data on 46,210 subjects, which included 80 incident cases of LADA, observed between 1984LADA, observed between and 1986LADA, observed between and 1995LADA, observed between and 1997 were available. Patients with LADA had antibodies against GAD and were insulin independent at diagnosis. RESULTS -FHD was associated with a four times (odds ratio [OR]3.92 [95% CI 2.76 -5.58]) increased prevalence of LADA. Corresponding estimates for type 2 and type 1 diabetes were 4.2 (3.72-4.75) and 2.78 (1.89 -4.10), respectively. Patients with LADA who had FHD had lower levels of C-peptide (541 vs. 715 pmol/l) and were more often treated with insulin (47 vs. 31%) than patients without FHD. Prospective data indicated that subjects with siblings who had diabetes had a 2.5 (1.39 -4.51) times increased risk of developing LADA during the 11-year follow-up compared with those without.CONCLUSIONS -This study indicates that FHD is a strong risk factor for LADA and that the influence of family history may be mediated through a heritable reduction of insulin secretion.

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Prevalence of known and previously unknown diabetes mellitus and impaired glucose tolerance in an adult Norwegian population. Indications of an increasing diabetes prevalence. the Nord-Trøndelag diabetes study

Abstract: The present diabetes prevalence was so high that interested general practitioners will get sufficient experience in follow-up of diabetic patients to facilitate a good quality of the care.

Cited by 38 publications

References 10 publications

Diabetes mellitus and outcomes of colorectal cancer

Diabetes mellitus and outcomes of colorectal cancer

Age, overweight and physical inactivity increase the risk of latent autoimmune diabetes in adults: results from the Nord-Trøndelag health study

Influence of Family History of Diabetes on Incidence and Prevalence of Latent Autoimmune Diabetes of the Adult

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