Prevalence of Ischemic and Hemorrhagic Strokes in Qena Governorate, Egypt: Community-based Study

Khedr, Eman M.; Fawi, Gharib; Abdela, Mohamed; Mohammed, Talal A.; Ahmed, Mohamed A.; El-Fetoh, Noha Abo; Zaki, Ahmed

doi:10.1016/j.jstrokecerebrovasdis.2014.03.001

Cited by 41 publications

(38 citation statements)

References 26 publications

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“…This involved the combination of clinical and laboratory parameters for large artery thrombosis, lacunar infarct, intracerebral hemorrhage, and subarachnoid hemorrhage. Khedr and colleagues did not state the case definition in their study on the prevalence of ischemic and hemorrhagic strokes in Qena Governorate, Egypt.…”

Section: Discussionmentioning

confidence: 99%

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The epidemiology of stroke in Africa: A systematic review of existing methods and new approaches

Owolabi

Olowoyo

Popoola

et al. 2017

J of Clinical Hypertension

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Accurate epidemiological surveillance of the burden of stroke is direly needed to facilitate the development and evaluation of effective interventions in Africa. The authors therefore conducted a systematic review of the methodology of stroke epidemiological studies conducted in Africa from 1970 to 2017 using gold standard criteria obtained from landmark epidemiological publications. Of 1330 articles extracted, only 50 articles were eligible for review grouped under incidence, prevalence, case-fatality, health-related quality of life, and disability-adjusted life-years studies. Because of various challenges, no study fulfilled the criteria for an excellent stroke incidence study.The relatively few stroke epidemiology studies in Africa have significant methodological flaws. Innovative approaches leveraging available information and communication technology infrastructure are recommended to facilitate rigorous epidemiological studies for accurate stroke surveillance in Africa.

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Section: Discussionmentioning

confidence: 99%

“…Despite the proposition that increased stroke occurrence is linked to gains in longevity on the continent, people of African descent clearly experience strokes at a younger age and have worse outcomes . Furthermore, Africa appears to have the highest incidence, prevalence, and case fatality rates of stroke …”

Section: Introductionmentioning

confidence: 99%

The epidemiology of stroke in Africa: A systematic review of existing methods and new approaches

Owolabi

Olowoyo

Popoola

et al. 2017

J of Clinical Hypertension

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“…Table 1 describes the characteristics of these studies, which S.A. Rammal and M.A. Almekhlafi came from KSA (7 studies), 13e19 Qatar (5 studies), 20e24 Kuwait (3 studies), 25e27 Bahrain (2 studies), 28,29 Libya (3 studies), 30e32 Egypt (1 study), 33 Jordan (2 studies), 34,35 Palestine (2 studies), 36,37 Sudan (1 study), 38 Iraq (2 studies), 39,40 and the United Arab Emirates (1 study). 41 The articles were published between 1986 and 2015.…”

Section: Resultsmentioning

confidence: 99%

Diabetes mellitus and stroke in the Arab world

Rammal

Almekhlafi

2016

Journal of Taibah University Medical Sciences

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Objectives: The relationship between diabetes mellitus and stroke in the Arab countries is underreported. In this review, we investigate the prevalence of diabetes mellitus among patients with stroke in the Arab world.Methods: We searched published literature to identify studies reporting on patients with stroke from the Arab countries. Eligible articles were reviewed to extract data on the frequency of diabetes among their samples and on the details of disease diagnostic criteria, control status and stroke subtypes. Results:We identified 29 studies reporting on a total of 10,242 patients. The estimated prevalence of diabetes among the ischaemic stroke population of these studies was 37.5%. None of the studies described the prevalence of diabetes among haemorrhagic patients with stroke. The criteria for diagnosing diabetes were not always described. Studies from the Gulf countries tended to report a higher prevalence of diabetes mellitus than studies from other Arab-world countries.Conclusions: There is insufficient reporting regarding the status of diabetes mellitus and its complications. The majority of studies suggest a remarkable variability in its prevalence. We hope that this review will draw attention to this prevalent health problem and prompt a better estimation of the impact of diabetes mellitus on the vascular health of our nations.

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“…The burden of stroke in Africa is higher and increasing, with stroke being among the leading causes of morbidity and mortality throughout continental Africa while the burden is less and appears to be declining in many high-income countries. 2 Globally, Africa has the highest burden of stroke with age standardized incidence of up to 316/100,000 37 ; age-adjusted prevalence of as high as1,460/100,000; 38, 39 one month fatality of up to 43% 40 , (compared to 4% North America) 2, 16, 41 , and 3 year fatality of 84% 42 . Furthermore, stroke afflicts the younger population (up to 15 years younger 2, 43 ), and presents with a higher proportion of the hemorrhagic type (34% in Africans, vs 9 % in high income countries).…”

Section: 0 Discussionmentioning

confidence: 99%

“…59 With future costs to generate WGS data reducing, WGS in large populations of continental Africans with stroke for discovery 39 ; followed by validation in African Americans, is the most plausible approach to discover and pinpoint causal variants for stroke with implications for the entire human race. This is due to the African origin of all humans and the substantially higher heritability of stroke among African ancestry populations.…”

Section: 0 Discussionmentioning

confidence: 99%

Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities

Owolabi

Peprah

et al. 2017

Journal of the Neurological Sciences

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Background We systematically reviewed the genetic variants associated with stroke in genome-wide association studies (GWAS) and examined the emerging priorities and opportunities for rapidly advancing stroke research in the era of Trans-Omics science. Methods Using the PRISMA guideline, we searched PubMed and NHGRI- EBI GWAS catalog for stroke studies from 2007 till May 2017. Results We included 31 studies. The major challenge is that the few validated variants could not account for the full genetic risk of stroke and have not been translated for clinical use. None of the studies included continental Africans. Genomic study of stroke among Africans presents a unique opportunity for the discovery, validation, functional annotation, trans-omics study and translation of genomic determinants of stroke with implications for global populations. This is because all humans originated from Africa, a continent with a unique genomic architecture and a distinctive epidemiology of stroke; as well as substantially higher heritability and resolution of fine mapping of stroke genes. Conclusion Understanding the genomic determinants of stroke and the corresponding molecular mechanisms will revolutionize the development of a new set of precise biomarkers for stroke prediction, diagnosis and prognostic estimates as well as personalized interventions for reducing the global burden of stroke.

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Prevalence of Ischemic and Hemorrhagic Strokes in Qena Governorate, Egypt: Community-based Study

Cited by 41 publications

References 26 publications

The epidemiology of stroke in Africa: A systematic review of existing methods and new approaches

The epidemiology of stroke in Africa: A systematic review of existing methods and new approaches

Diabetes mellitus and stroke in the Arab world

Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities

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